Midcareer investigator award in patient-oriented research in the area of perinatal-developmental neuroscience

围产期发育神经科学领域以患者为导向的研究中的职业生涯中期研究员奖

• 批准号: 10684741
• 负责人: Marisa N Spann
• 金额: $ 16.1万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10684741
• 关键词: Age; Anterior; Anxiety; Area; Attention; Autoimmune Diseases; Behavior Therapy; Behavioral; Behavioral Symptoms; Biological; Biological Markers; Blood Glucose; Body mass index; Brain; Brain region; Child; Childhood; Cognitive; Computerized Medical Record; Data; Data Collection; Data Pooling; Data Set; Development; Diagnosis; Dimensions; Distress; Dorsal; Early Diagnosis; Early identification; Ensure; Funding; Funding Mechanisms; Future; Goals; Health; Health education; High Prevalence; Hydrocortisone; Image; Immune system; Infant; Infection; Inflammation; Insula of Reil; International; Intervention; Knowledge; Laboratories; Life Style; Link; Literature; Magnetic Resonance Imaging; Manuscripts; Maps; Medial; Mediating; Medical center; Mental Depression; Mental Health; Mental Health Services; Mental disorders; Mentors; Mentorship; Midcareer Investigator Award in Patient-Oriented Research; Mothers; National Institute of Child Health and Human Development; National Institute of Mental Health; Neonatal; Neurobiology; Neurosciences; Obesity; Outcome; Pathway interactions; Perinatal; Pilot Projects; Positioning Attribute; Prefrontal Cortex; Pregnancy; Pregnant Women; Procedures; Productivity; Program Development; Public Health; Regulation; Research; Research Domain Criteria; Research Personnel; Research Training; Resources; Risk; Rodent Model; Role; Salivary; Sampling; School-Age Population; Science; Scientist; Series; Stress; Structure; Symptoms; Thalamic structure; Toddler; Training; Training Activity; Training Programs; Training Support; United States National Institutes of Health; Universities; Work; advanced analytics; analytical method; antepartum depression; brain based; brain morphology; brain pathway; brain volume; career; career development; career networking; cingulate cortex; cohort; diabetes risk; environmental stressor; experience; fetal; health information technology; human model; hypothalamic-pituitary-adrenal axis; improved; indexing; interest; intergenerational; maternal depression; neuroimaging; next generation; obesity risk; offspring; patient oriented; patient oriented research; patient population; personalized approach; prenatal; prenatal exposure; prenatal health; prenatal influence; programs; psychiatric symptom; psychological distress; psychological stressor; research study; skills; socioeconomics; success

Despite evidence that 1 in 5 children are at risk for psychiatric disorders, only 1 in 20 young children receive mental health care. Thus, a high number of children who would benefit from mental health care remain untreated. My long-term goal is to improve brain-based targets for early detection and behavioral interventions of childhood psychiatric disorders. The area of perinatal-developmental neuroscience (PDN) is of high public health significance as a substantial proportion of pregnant women will experience health, environmental, or psychological stressors, which have early and long-lasting effects on offspring. Increasing the number of research programs that can support training in PDN is paramount. The K24 will allow me to: 1) expand my expertise in advanced analytic methods to support trainee research, and 2) establish an internationally recognized research and training program focused on fetal-infant brain and behavioral origins of mental health. My K24 training program, the Columbia Engagement, Stability, and Success in PDN will provide an individualized approach to research training: assessing the research skills and career goals of mentees early on and developing personalized training modules; didactics; experiential, hands-on training; and research productivity that follow their individualized plan. The program also includes a monthly seminar series alternating between science and career-networking topics. Our prior studies suggest there may be common biological pathways by which early exposures exert their influence on offspring conferring psychiatric risk – with recent attention to the immune system and/or hypothalamic-pituitary-adrenal axis, and brain regions involved in behavioral regulation. Using the expanded analytic skills obtained through this K24, my mentees and I will conduct studies to examine whether four key prenatal exposures: maternal depression, body mass index, infection, and blood glucose are associated with connectivity and morphology of brain regions (e.g., dorsal anterior cingulate) involved in behavioral regulation. In a subset of the cohort, we will also consider the potential mediating effects of inflammation and glucocorticosteriods. I have a unique opportunity to pool data from cohorts of pregnant women-fetal dyads involved in research studies (2004 to present; n~500) at Columbia University Irving Medical Center – a large center with a diverse patient population – and perform new data collection harnessing health information technology (e.g., electronic medical records). The data set will serve as a platform for my mentees to produce pilot projects and manuscripts, and practical experience conducting a project in an area of PDN that matches his/her career goals within the scope of this funding mechanism. My strong commitment to and ongoing research in patient-oriented research focused on identifying early antecedents of psychiatric risk, individualized mentorship plans, direct involvement of mentees in the conduct of research, and tailored career development program at Columbia University Irving Medical Center are strengths of this application. The K24 mentees will be uniquely positioned to discover neurobiological and behavioral pathways associated with risk.

尽管有证据表明，五分之一的儿童有患精神疾病的风险，但只有二十分之一的幼儿接受 心理健康护理因此，大量本可受益于精神保健的儿童仍然得不到治疗。 我的长期目标是改善儿童早期发现和行为干预的大脑目标 精神疾病围产期发育神经科学（PDN）领域是高度公共卫生领域 重要的是，相当一部分孕妇将经历健康、环境或 心理压力，这对后代有早期和长期的影响。使更多的 支持PDN培训的研究计划至关重要。K24将允许我：1）扩展我的 在先进的分析方法的专业知识，以支持学员的研究，和2）建立一个国际 公认的研究和培训计划，重点是胎儿-婴儿的大脑和心理健康的行为起源。 我的K24培训计划，哥伦比亚参与，稳定性和PDN的成功将提供个性化的 研究培训方法：早期评估学员的研究技能和职业目标并制定 个性化培训模块;教学法;体验式实践培训;以及随之而来的研究生产力 个性化的计划。该计划还包括一个每月的研讨会系列之间交替科学和 职业网络话题。我们先前的研究表明，可能有共同的生物学途径， 暴露对后代产生影响，赋予精神病风险-最近的注意力集中在免疫方面。 系统和/或下丘脑-垂体-肾上腺轴，以及参与行为调节的脑区。使用 通过K24获得的扩展分析技能，我和我的学员将进行研究，以检查是否 四个关键的产前暴露：母亲抑郁，体重指数，感染和血糖相关 利用脑区域的连通性和形态（例如，背侧前扣带回）参与行为 调控在队列的一个子集中，我们还将考虑炎症的潜在介导作用， 糖皮质激素我有一个独特的机会来收集孕妇胎儿二联体的数据 参与哥伦比亚大学欧文医学中心的研究（2004年至今; n~500）-一个大型 以多样化的患者人群为中心-并利用健康信息进行新的数据收集 技术（例如，电子病历）。数据集将作为一个平台， 试点项目和手稿，以及在PDN领域开展项目的实践经验， 他/她在此资助机制范围内的职业目标。我坚定的承诺和正在进行的研究 在以患者为导向的研究中，重点是确定精神病风险的早期前因， 指导计划、指导对象直接参与研究以及量身定制的职业发展 在哥伦比亚大学欧文医学中心的计划是这个应用程序的优势。K24学员将 在发现与风险相关的神经生物学和行为途径方面具有独特的地位。

项目成果

The effects of experience of discrimination and acculturation during pregnancy on the developing offspring brain.

• DOI: 10.1038/s41386-023-01765-3
• 发表时间: 2024-01
• 期刊: NEUROPSYCHOPHARMACOLOGY
• 影响因子: 7.6
• 作者: Spann, Marisa N.;Alleyne, Kiarra;Holland, Cristin M.;Davids, Antonette;Pierre-Louis, Arline;Bang, Claire;Oyeneye, Victoria;Kiflom, Rebecca;Shea, Eileen;Cheng, Bin;Peterson, Bradley S.;Monk, Catherine;Scheinost, Dustin
• 通讯作者: Scheinost, Dustin