Midcareer investigator award in patient-oriented research in the area of perinatal-developmental neuroscience
围产期发育神经科学领域以患者为导向的研究中的职业生涯中期研究员奖
基本信息
- 批准号:10284408
- 负责人:
- 金额:$ 16.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-01 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AgeAnteriorAnxietyAreaAttentionAutoimmune DiseasesBase of the BrainBehavior TherapyBehavioralBehavioral SymptomsBiologicalBiological MarkersBlood GlucoseBody mass indexBrainBrain regionChildChildhoodCognitiveComputerized Medical RecordDataData CollectionData PoolingData SetDevelopmentDiagnosisDimensionsDistressDorsalEarly DiagnosisEnsureFundingFunding MechanismsFutureGoalsHealthHealth educationHealthcareHigh PrevalenceHydrocortisoneImageImmune systemInfantInfectionInflammationInsula of ReilInternationalInterventionKnowledgeLaboratoriesLife StyleLinkLiteratureMagnetic Resonance ImagingManuscriptsMapsMedialMediatingMedical centerMental DepressionMental HealthMental disordersMentorsMentorshipMidcareer Investigator Award in Patient-Oriented ResearchMothersNational Institute of Child Health and Human DevelopmentNational Institute of Mental HealthNeonatalNeurobiologyNeurosciencesObesityOutcomePathway interactionsPerinatalPilot ProjectsPositioning AttributePrefrontal CortexPregnancyPregnant WomenProceduresProductivityProgram DevelopmentPublic HealthRegulationResearchResearch Domain CriteriaResearch PersonnelResearch TrainingResourcesRiskRodent ModelRoleSalivarySamplingSchool-Age PopulationScienceScientistSeriesStressStructureSymptomsThalamic structureTimeToddlerTrainingTraining ActivityTraining ProgramsTraining SupportUnited States National Institutes of HealthUniversitiesWorkadvanced analyticsanalytical methodantepartum depressionbrain morphologybrain pathwaybrain volumecareercareer developmentcareer networkingcingulate cortexcohortdiabetes riskenvironmental stressorexperiencefetalhealth information technologyhuman modelhypothalamic-pituitary-adrenal axisimprovedindexinginterestintergenerationalmaternal depressionneuroimagingnext generationobesity riskoffspringpatient orientedpatient oriented researchpatient populationpersonalized approachprenatalprenatal exposureprenatal healthprenatal influenceprogramspsychiatric symptompsychological distresspsychological stressorresearch studyskillssocioeconomicssuccess
项目摘要
Despite evidence that 1 in 5 children are at risk for psychiatric disorders, only 1 in 20 young children receive
mental health care. Thus, a high number of children who would benefit from mental health care remain untreated.
My long-term goal is to improve brain-based targets for early detection and behavioral interventions of childhood
psychiatric disorders. The area of perinatal-developmental neuroscience (PDN) is of high public health
significance as a substantial proportion of pregnant women will experience health, environmental, or
psychological stressors, which have early and long-lasting effects on offspring. Increasing the number of
research programs that can support training in PDN is paramount. The K24 will allow me to: 1) expand my
expertise in advanced analytic methods to support trainee research, and 2) establish an internationally
recognized research and training program focused on fetal-infant brain and behavioral origins of mental health.
My K24 training program, the Columbia Engagement, Stability, and Success in PDN will provide an individualized
approach to research training: assessing the research skills and career goals of mentees early on and developing
personalized training modules; didactics; experiential, hands-on training; and research productivity that follow
their individualized plan. The program also includes a monthly seminar series alternating between science and
career-networking topics. Our prior studies suggest there may be common biological pathways by which early
exposures exert their influence on offspring conferring psychiatric risk – with recent attention to the immune
system and/or hypothalamic-pituitary-adrenal axis, and brain regions involved in behavioral regulation. Using the
expanded analytic skills obtained through this K24, my mentees and I will conduct studies to examine whether
four key prenatal exposures: maternal depression, body mass index, infection, and blood glucose are associated
with connectivity and morphology of brain regions (e.g., dorsal anterior cingulate) involved in behavioral
regulation. In a subset of the cohort, we will also consider the potential mediating effects of inflammation and
glucocorticosteriods. I have a unique opportunity to pool data from cohorts of pregnant women-fetal dyads
involved in research studies (2004 to present; n~500) at Columbia University Irving Medical Center – a large
center with a diverse patient population – and perform new data collection harnessing health information
technology (e.g., electronic medical records). The data set will serve as a platform for my mentees to produce
pilot projects and manuscripts, and practical experience conducting a project in an area of PDN that matches
his/her career goals within the scope of this funding mechanism. My strong commitment to and ongoing research
in patient-oriented research focused on identifying early antecedents of psychiatric risk, individualized
mentorship plans, direct involvement of mentees in the conduct of research, and tailored career development
program at Columbia University Irving Medical Center are strengths of this application. The K24 mentees will be
uniquely positioned to discover neurobiological and behavioral pathways associated with risk.
尽管有证据表明,五分之一的儿童有患精神疾病的风险,但只有二十分之一的幼儿接受了治疗
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Marisa N Spann其他文献
Brain age prediction and deviations from normative trajectories in the neonatal connectome
脑年龄预测和新生儿连接组正常轨迹的偏差
- DOI:
10.1101/2024.04.23.590811 - 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Huili Sun;Saloni Mehta;Milana Khaitova;Bin Cheng;Xuejun Hao;Marisa N Spann;Dustin Scheinost - 通讯作者:
Dustin Scheinost
Marisa N Spann的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Marisa N Spann', 18)}}的其他基金
Midcareer investigator award in patient-oriented research in the area of perinatal-developmental neuroscience
围产期发育神经科学领域以患者为导向的研究中的职业生涯中期研究员奖
- 批准号:
10684741 - 财政年份:2021
- 资助金额:
$ 16.1万 - 项目类别:
Midcareer investigator award in patient-oriented research in the area of perinatal-developmental neuroscience
围产期发育神经科学领域以患者为导向的研究中的职业生涯中期研究员奖
- 批准号:
10472708 - 财政年份:2021
- 资助金额:
$ 16.1万 - 项目类别:
Maternal Immune Activation and Fetal-Infant Neurobehavioral Development
母体免疫激活和胎儿-婴儿神经行为发育
- 批准号:
9527362 - 财政年份:2018
- 资助金额:
$ 16.1万 - 项目类别:
Infection, fever and immunity and offspring ADHD in a population-based pregnancy/birth cohort
基于人群的妊娠/出生队列中的感染、发烧和免疫以及后代多动症
- 批准号:
10174976 - 财政年份:2017
- 资助金额:
$ 16.1万 - 项目类别:
相似海外基金
Impact of tissue resident memory T cells on the neuro-immune pathophysiology of anterior eye disease
组织驻留记忆 T 细胞对前眼疾病神经免疫病理生理学的影响
- 批准号:
10556857 - 财政年份:2023
- 资助金额:
$ 16.1万 - 项目类别:
Fear and anxiety circuit mechanisms in anterior hypothalamic nucleus
下丘脑前核的恐惧和焦虑环路机制
- 批准号:
10789153 - 财政年份:2023
- 资助金额:
$ 16.1万 - 项目类别:
Elucidating signaling networks in Anterior Segment development, repair and diseases
阐明眼前节发育、修复和疾病中的信号网络
- 批准号:
10718122 - 财政年份:2023
- 资助金额:
$ 16.1万 - 项目类别:
The Intimate Interplay Between Keratoconus, Sex Hormones, and the Anterior Pituitary
圆锥角膜、性激素和垂体前叶之间的密切相互作用
- 批准号:
10746247 - 财政年份:2023
- 资助金额:
$ 16.1万 - 项目类别:
Anterior Insula Projections for Alcohol Drinking/Anxiety Interactions in Female and Male Rats
雌性和雄性大鼠饮酒/焦虑相互作用的前岛叶预测
- 批准号:
10608759 - 财政年份:2023
- 资助金额:
$ 16.1万 - 项目类别:
Impact of tissue resident memory T cells on the neuro-immunepathophysiology of anterior eye disease
组织驻留记忆 T 细胞对前眼疾病神经免疫病理生理学的影响
- 批准号:
10804810 - 财政年份:2023
- 资助金额:
$ 16.1万 - 项目类别:
Investigation of the effect of anterior eye shape on myopia progression due to prolonged near work.
研究因长时间近距离工作而导致的前眼形状对近视进展的影响。
- 批准号:
23K09063 - 财政年份:2023
- 资助金额:
$ 16.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Generation and characterization of anterior pituitary stem cells from human pluripotent stem cells
人多能干细胞垂体前叶干细胞的产生和表征
- 批准号:
23K08005 - 财政年份:2023
- 资助金额:
$ 16.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Anterior cruciate ligament injury: towards a gendered environmental approach
前十字韧带损伤:走向性别环境方法
- 批准号:
485090 - 财政年份:2023
- 资助金额:
$ 16.1万 - 项目类别:
Operating Grants
EASI-TOC: Endovascular Acute Stroke Intervention-Tandem OCclusion: atrial of acute cervical internal carotid artery stenting during endovascularthrombectomy for anterior circulation stroke
EASI-TOC:血管内急性卒中干预-串联闭塞:前循环卒中血管内血栓切除术期间急性颈内动脉心房支架置入术
- 批准号:
490056 - 财政年份:2023
- 资助金额:
$ 16.1万 - 项目类别:
Operating Grants