Clinical and Translational Science Institute at Childrens National
国家儿童医院临床与转化科学研究所
基本信息
- 批准号:9534792
- 负责人:
- 金额:$ 514.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-07-01 至 2021-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAreaCaringChildChild HealthChildhoodClinicClinicalClinical ResearchClinical SciencesCollaborationsCommunitiesCommunity IntegrationDevelopmentDevicesDiseaseDiverse WorkforceEthicsEvaluationFamilyGenerationsGenetic DiseasesGoalsHealthHealth systemHome environmentHumanInstitute of Medicine (U.S.)InstitutesLeadershipLinkLongevityMentorsMethodsMissionOutcomePediatric ResearchPopulationPositioning AttributeProcessQuality of lifeReportingResearchResearch InfrastructureResearch PersonnelScienceServicesSiteTechnologyTrainingTranslational ResearchTranslationsUniversitiesVirginiaVisionWashingtonWorkforce Developmentcatalystclinical practicecost effectivedesigndisease heterogeneityhealth applicationimprovedinnovationinter-institutionalmultidisciplinarynovelprogramstranslational pipelinetreatment strategy
项目摘要
OVERALL: PROJECT ABSTRACT
Although children comprise one-quarter of the US population, only 10% of ClinicalTrials.gov registered studies
focus on child health-related clinical and translational research (CTR). The mission of the Clinical and
Translational Science Institute at Children's National (CTSI-CN) is to address the barriers and serve as a hub
within the CTSA Network that is focused on the promotion of child health CTR. Established in 2010, the
inaugural CTSI-CN (CTSI-CN v1.0) was organized as a collaboration between Children's National Health
System (CNHS) and its academic partner, The George Washington University (GW). Over the past four years,
CTSI-CN v1.0 has positioned itself as an effective catalyst for child-health CTR around four major themes: 1)
improving the health of children and their families; 2) developing novel treatment strategies for rare genetic
diseases; 3) designing new devices for pediatric care; and 4) characterizing childhood precursors of disease
along the lifespan. We have embraced many of the tenets recommended in the July 2013 Institute of Medicine
(IOM) report, specifically, developing multidisciplinary teams, providing cost-effective services and support for
investigators, and streamlining processes that impact the effective conduct of CTR. The CTSI-CN is
acknowledged locally as the hub for effective, high quality child health CTR and as a nurturing, integrated
home for CTR team science. Nationally, the CTSI-CN has provided leadership in child health CTR, in both
CTSA- and non-CTSA-linked consortia and steering committees. In the current proposal (CTSI-CN v2.0), we
will continue to advance our vision and mission through innovative approaches and enhanced capabilities in
our strategic themes. To this end, we have expanded our partnership to include Virginia Tech (VT) and its
clinical partner, the Carilion Clinic. The goals of CTSI-CN v2.0, which will build on our established strengths,
the lessons learned in CTSI-CN v1.0, and our new partnership with VT/Carilion (VTC), will also address the
four NCATS strategic themes by: 1) developing a new generation of diverse, high quality child health-focused
CTR investigators through innovative, inter-institutional educational, training, and mentoring programs
(WORKFORCE DEVELOPMENT); 2) creating innovative approaches and technologies to catalyze CTR,
particularly in child-health, through novel cross-disciplinary and inter-institutional collaborations with multiple
stakeholder communities (COLLABORATION AND ENGAGEMENT); 3) catalyzing the development,
dissemination and evaluation of novel methods to enhance translational science, with a particular emphasis on
the child-health CTR spectrum (METHODS AND PROCESSES); 4) enhancing quality and efficiency across
the translational spectrum through a) the integration of a high quality diverse workforce, b) implementation of
new methods and processes, and c) collaboration among the institutional partners and communities
(INTEGRATION): and 5) providing leadership within the CTSA Network through multi-site collaborations and
educational programs, with a particular emphasis on child-health CTR and outcomes (CTSA NETWORK).
总体:项目摘要
虽然儿童占美国人口的四分之一,但只有10%的ClinicalTrials.gov注册研究
专注于儿童健康相关的临床和转化研究(CTR)。临床和实验室的使命
儿童国家转化科学研究所(CTSI-CN)将解决这些障碍,并作为一个中心
在CTSA网络内,重点是促进儿童健康CTR。成立于2010年,
首届CTSI-CN(CTSI-CN v1.0)是由儿童国家卫生部和
系统(CNHS)及其学术合作伙伴,乔治华盛顿大学(GW)。在过去的四年里,
CTSI-CN v1.0围绕四大主题将自己定位为儿童健康CTR的有效催化剂:1)
改善儿童及其家庭的健康; 2)开发罕见遗传病的新治疗策略
疾病; 3)设计儿科护理的新设备;以及4)描述儿童疾病的前兆
沿着生命周期。我们已经接受了2013年7月医学研究所建议的许多原则
(IOM)报告,具体而言,发展多学科小组,提供具有成本效益的服务和支持,
调查员,并精简影响有效开展合作减少风险的程序。CTSI-CN是
在当地被公认为有效、高质量的儿童健康CTR中心,
CTR团队科学家的家在全国范围内,CTSI-CN在儿童健康CTR方面发挥了领导作用,无论是在
CTSA和非CTSA关联财团和指导委员会。在当前提案(CTSI-CN v2.0)中,我们
将继续通过创新方法和增强能力,推进我们的愿景和使命,
我们的战略主题。为此,我们扩大了我们的合作伙伴关系,包括弗吉尼亚理工大学(VT)及其
临床合作伙伴,Carnival诊所。CTSI-CN v2.0的目标将建立在我们现有的优势之上,
从CTSI-CN v1.0中吸取的经验教训,以及我们与VT/Carnival(VTC)的新伙伴关系,也将解决
四个NCATS战略主题:1)发展新一代多样化,高质量的儿童健康为重点
通过创新的机构间教育、培训和指导计划,
(员工发展); 2)创造创新的方法和技术,以促进CTR,
特别是在儿童健康方面,通过与多个机构的新的跨学科和机构间合作,
利益相关者社区(协作和参与); 3)促进发展,
传播和评估新方法,以加强翻译科学,特别强调
儿童健康CTR谱(方法和步骤); 4)提高整个系统的质量和效率
通过a)整合高质量的多样化劳动力,B)实施
新的方法和程序,以及c)机构伙伴和社区之间的合作
(整合):5)通过多站点协作在CTSA网络内提供领导,
教育方案,特别强调儿童健康CTR和成果(CTSA网络)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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LISA MARIE GUAY-WOODFORD其他文献
LISA MARIE GUAY-WOODFORD的其他文献
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{{ truncateString('LISA MARIE GUAY-WOODFORD', 18)}}的其他基金
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Clinical, Translational, and Biorepository Resource
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC) - 临床、转化和生物样本库资源
- 批准号:
10455719 - 财政年份:2020
- 资助金额:
$ 514.83万 - 项目类别:
Decoding reno-protective mechanisms in mouse Pkhd1 models: Implications for ARPKD therapeutics
解码小鼠 Pkhd1 模型中的肾脏保护机制:对 ARPKD 治疗的影响
- 批准号:
10170340 - 财政年份:2020
- 资助金额:
$ 514.83万 - 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Clinical, Translational, and Biorepository Resource
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC) - 临床、转化和生物样本库资源
- 批准号:
10685977 - 财政年份:2020
- 资助金额:
$ 514.83万 - 项目类别:
Decoding reno-protective mechanisms in mouse Pkhd1 models: Implications for ARPKD therapeutics
解码小鼠 Pkhd1 模型中的肾脏保护机制:对 ARPKD 治疗的影响
- 批准号:
10382438 - 财政年份:2020
- 资助金额:
$ 514.83万 - 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Clinical, Translational, and Biorepository Resource
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC) - 临床、转化和生物样本库资源
- 批准号:
10218162 - 财政年份:2020
- 资助金额:
$ 514.83万 - 项目类别:
UAB CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE (CCTS) UL1
阿拉巴马大学临床与转化科学中心 (CCTS) UL1
- 批准号:
8365094 - 财政年份:2011
- 资助金额:
$ 514.83万 - 项目类别:
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