CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH

CTSA 儿科研究基础设施

• 批准号: 8365096
• 负责人: LISA MARIE GUAY-WOODFORD
• 金额: $ 141.44万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365096
• 关键词: Clinical Sciences; Pediatric Research; Research Infrastructure; Translational Research

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. In 2007, the University of Alabama at Birmingham (DAB) and its affiliates completed three important, large- scale strategic planning efforts. Together, these processes generated a "blueprint for our research future" :hat lays the foundation to transform our substantial clinical and translational research enterprise through ntegration and innovation across all disciplines, Schools, and our health care system. This transformation will be driven by the DAB Center for Clinical and Translational Science (CCTS). The CCTS vision is to transform the DAB environment by building productive and efficient interdisciplinary research teams through educational ingenuity, regulatory reorganization, resource coordination, and methodological innovation. The mission is to develop a transformative infrastructure that spans the spectrum from preclinical research to bench-to-bedside translation (T1 research) to community implementation (T2 research), and will meet 5 goals: 1) transform the Investigator; 2) transform the Training Environment; 3) transform the Resource Infrastructure; 4) transform the Approach to Interdisciplinary Research via an emphasis on outcomes research and health disparities research; and 5) establish a new Research Model through the Self-Monitoring and Improvement Program. To meet these goals, the CCTS will rely on: 1) a re-organized reporting structure that assures the PI full institutional support in implementing the CCTS roadmap; 2) a revised CCTS leadership that includes faculty from the Schools of Medicine, Public Health, Nursing, Health Professions, and Optometry; and 3) innovative partnerships involving UAB, Southern Research Institute (our affiliated, not-for-profit research organization for preclinical drug discovery/development), the Children's Health System, the HudsonAlpha Institute for Biotechnology, the greater Birmingham community, and a long-standing collaborative network that involves Historically Black Colleges and Universities (HBCUs) and underprivileged communities in our region. UAB, the Health System, Health Services Foundation, Research Foundation, and Southern Research Institute have made substantial commitments to the CCTS including: 1) significant new funding for the clinical and translational research infrastructure (~$150 million, of which over $18 million are directly for CCTS activities and programs); 2) a redesigned and enhanced biomedical informatics infrastructure; and 3) over 20,000 sf of prime clinical and administrative space. When combined, the re-organized CCTS governance and leadership, the substantial commitment of funds and resources, the interdisciplinary culture of UAB, and the new CCTS programs, will create a transformed environment for clinical and translational research that will benefit our trainees, investigators, patients, community, and the national CTSA effort.

该子项目代表CTSA资金百分比的估计值 被用于广泛的研究领域（艾滋病研究，儿科研究或 临床试验）。 列出的总成本只是CTSA数量的估计值 基础设施朝向这一研究领域，而不是直接提供的资金 NCRR授予subproject或subproject人员。 2007年，阿拉巴马大学伯明翰（DAB）及其分支机构完成了三项重要的大规模战略规划工作。这些过程共同产生了“我们的研究未来的蓝图”：帽子奠定了基础，以通过所有学科，学校和我们的医疗保健系统的NTEGRATION和INEOVATION来改变我们实质性的临床和转化研究企业。这种转变将由DAB临床和转化科学中心（CCT）驱动。 CCT的愿景是通过教育创造力，监管重组，资源协调和方法论创新来建立生产力，高效的跨学科研究团队来改变DAB环境。任务是开发一种变革性的基础设施，该基础设施跨越了从临床前研究到卧铺到床边翻译（T1研究）再到社区实施（T2研究）的频谱，并将达到5个目标：1）改变研究者； 2）改变训练环境； 3）改变资源基础架构； 4）通过强调结果研究和健康差异研究来改变跨学科研究的方法； 5）通过自我监控和改进计划建立新的研究模型。为了实现这些目标，CCT将依靠：1）重新组织的报告结构，确保PI在实施CCTS路线图方面提供全部机构支持； 2）经过修订的CCTS领导，包括医学院，公共卫生，护理，卫生专业和验光的教师； 3）涉及UAB，南部研究所（我们的非属性，非营利性临床前药物发现/发展研究组织），儿童卫生系统，Hudsonalpha生物技术研究所，大伯明翰社区，大伯明翰社区以及涉及历史上历史上的黑人大学和不下层的史无前例（HBCCOUS）的创新伙伴关系。 UAB，卫生系统，卫生服务基金会，研究基金会和南部研究所对CCT做出了重大承诺，包括：1）临床和转化研究基础设施的大量新资金（约1.5亿美元，其中超过1800万美元直接用于CCTS活动和计划）； 2）重新设计和增强的生物医学信息学基础设施； 3）超过20,000平方英尺的主要临床和行政空间。合并后，重组的CCTS治理和领导力，资金和资源的实质性承诺，UAB的跨学科文化以及新的CCTS计划将为临床和转化研究创造一个转变的环境，从而使我们的受训者，研究人员，患者，社区和国家CTSA努力受益。