CTSA INFRASTRUCTURE FOR AIDS RESEARCH

CTSA 艾滋病研究基础设施

• 批准号: 8365097
• 负责人: LISA MARIE GUAY-WOODFORD
• 金额: $ 23.61万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365097
• 关键词: Acquired Immunodeficiency Syndrome; Clinical Sciences; Research; Research Infrastructure; Translational Research

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. In 2007, the University of Alabama at Birmingham (DAB) and its affiliates completed three important, large- scale strategic planning efforts. Together, these processes generated a "blueprint for our research future" :hat lays the foundation to transform our substantial clinical and translational research enterprise through ntegration and innovation across all disciplines, Schools, and our health care system. This transformation will be driven by the DAB Center for Clinical and Translational Science (CCTS). The CCTS vision is to transform the DAB environment by building productive and efficient interdisciplinary research teams through educational ingenuity, regulatory reorganization, resource coordination, and methodological innovation. The mission is to develop a transformative infrastructure that spans the spectrum from preclinical research to bench-to-bedside translation (T1 research) to community implementation (T2 research), and will meet 5 goals: 1) transform the Investigator; 2) transform the Training Environment; 3) transform the Resource Infrastructure; 4) transform the Approach to Interdisciplinary Research via an emphasis on outcomes research and health disparities research; and 5) establish a new Research Model through the Self-Monitoring and Improvement Program. To meet these goals, the CCTS will rely on: 1) a re-organized reporting structure that assures the PI full institutional support in implementing the CCTS roadmap; 2) a revised CCTS leadership that includes faculty from the Schools of Medicine, Public Health, Nursing, Health Professions, and Optometry; and 3) innovative partnerships involving UAB, Southern Research Institute (our affiliated, not-for-profit research organization for preclinical drug discovery/development), the Children's Health System, the HudsonAlpha Institute for Biotechnology, the greater Birmingham community, and a long-standing collaborative network that involves Historically Black Colleges and Universities (HBCUs) and underprivileged communities in our region. UAB, the Health System, Health Services Foundation, Research Foundation, and Southern Research Institute have made substantial commitments to the CCTS including: 1) significant new funding for the clinical and translational research infrastructure (~$150 million, of which over $18 million are directly for CCTS activities and programs); 2) a redesigned and enhanced biomedical informatics infrastructure; and 3) over 20,000 sf of prime clinical and administrative space. When combined, the re-organized CCTS governance and leadership, the substantial commitment of funds and resources, the interdisciplinary culture of UAB, and the new CCTS programs, will create a transformed environment for clinical and translational research that will benefit our trainees, investigators, patients, community, and the national CTSA effort.

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 基础设施走向这一领域的研究，而不是直接提供资金， 向子项目或子项目工作人员提供NCRR补助金。 2007年，亚拉巴马大学伯明翰分校（DAB）及其附属机构完成了三项重要的、大规模的战略规划工作。总之，这些过程产生了“我们的研究未来的蓝图”：帽子奠定了基础，通过整合和创新，在所有学科，学校和我们的医疗保健系统改造我们的实质性临床和转化研究企业。这一转变将由DAB临床和转化科学中心（CCTS）推动。CCTS的愿景是通过教育创新，监管重组，资源协调和方法创新，建立富有成效和高效的跨学科研究团队，从而改变DAB环境。我们的使命是开发一个变革性的基础设施，涵盖从临床前研究到实验室到床边的翻译（T1研究）到社区实施（T2研究），并将满足5个目标：1）改变研究者; 2）改变培训环境; 3）改变资源基础设施; 4）通过强调结果研究和健康差异研究来转变跨学科研究的方法; 5）通过自我监测和改进计划建立新的研究模式。为了实现这些目标，CCTS将依赖于：1）重新组织的报告结构，确保PI在实施CCTS路线图时得到充分的机构支持; 2）修订后的CCTS领导层，包括医学院、公共卫生学院、护理学院、健康护理学院和验光学院的教师;和3）涉及UAB，南方研究所的创新伙伴关系（我们的附属，非营利研究组织的临床前药物发现/开发），儿童健康系统，哈德逊阿尔法生物技术研究所，大伯明翰社区，以及一个长期的合作网络，涉及历史上的黑人学院和大学（HBCU）和我们地区的贫困社区。UAB、卫生系统、卫生服务基金会、研究基金会和南方研究所对CCTS做出了重大承诺，包括：1）为临床和转化研究基础设施提供大量新资金（约1.5亿美元，其中超过1800万美元直接用于CCTS活动和计划）; 2）重新设计和增强生物医学信息学基础设施;以及3）超过20，000平方英尺的优质临床和行政空间。合并后，重组的CCTS治理和领导，资金和资源的大量承诺，UAB的跨学科文化，以及新的CCTS计划，将为临床和转化研究创造一个转变的环境，这将有利于我们的学员，研究人员，患者，社区和国家CTSA的努力。