CTSA INFRASTRUCTURE FOR AIDS RESEARCH

该子项目代表了 CTSA 资金百分比的估计 被用于广泛的研究领域（艾滋病研究、儿科研究或 临床试验）。 列出的总成本只是 CTSA 金额的估计值 该研究领域的基础设施，而不是直接资助 NCRR 向子项目或子项目人员提供的补助金。 2007 年，阿拉巴马大学伯明翰分校 (DAB) 及其附属机构完成了三项重要的大规模战略规划工作。这些过程共同生成了“我们研究未来的蓝图”：这为通过所有学科、学校和医疗保健系统的整合和创新来转变我们的实质性临床和转化研究事业奠定了基础。这一转变将由 DAB 临床和转化科学中心 (CCTS) 推动。 CCTS 的愿景是通过教育独创性、监管重组、资源协调和方法创新，建立富有成效的跨学科研究团队，从而改变 DAB 环境。其使命是开发一个变革性的基础设施，涵盖从临床前研究到临床转化（T1 研究）再到社区实施（T2 研究）的范围，并将实现 5 个目标：1）改变研究者； 2）改造培训环境； 3）改造资源基础设施； 4) 通过强调结果研究和健康差异研究来转变跨学科研究方法； 5) 通过自我监控和改进计划建立新的研究模式。为了实现这些目标，CCTS 将依靠： 1) 重新组织的报告结构，确保 PI 在实施 CCTS 路线图时获得全面的机构支持； 2) 修订后的 CCTS 领导层，包括来自医学院、公共卫生学院、护理学院、卫生专业学院和验光学院的教员； 3) 创新伙伴关系，涉及 UAB、南方研究所（我们附属的非营利性临床前药物发现/开发研究组织）、儿童健康系统、HudsonAlpha 生物技术研究所、大伯明翰社区，以及涉及我们地区传统黑人学院和大学 (HBCU) 和贫困社区的长期合作网络。 UAB、卫生系统、卫生服务基金会、研究基金会和南方研究所对 CCTS 做出了重大承诺，包括：1）为临床和转化研究基础设施提供大量新资金（约 1.5 亿美元，其中超过 1800 万美元直接用于 CCTS 活动和项目）； 2）重新设计和增强的生物医学信息学基础设施； 3) 超过 20,000 平方英尺的主要临床和行政空间。重组后的 CCTS 治理和领导层、资金和资源的大量承诺、UAB 的跨学科文化以及新的 CCTS 项目相结合，将为临床和转化研究创造一个转变的环境，这将使我们的学员、研究人员、患者、社区和国家 CTSA 工作受益。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. In 2007, the University of Alabama at Birmingham (DAB) and its affiliates completed three important, large- scale strategic planning efforts. Together, these processes generated a "blueprint for our research future" :hat lays the foundation to transform our substantial clinical and translational research enterprise through ntegration and innovation across all disciplines, Schools, and our health care system. This transformation will be driven by the DAB Center for Clinical and Translational Science (CCTS). The CCTS vision is to transform the DAB environment by building productive and efficient interdisciplinary research teams through educational ingenuity, regulatory reorganization, resource coordination, and methodological innovation. The mission is to develop a transformative infrastructure that spans the spectrum from preclinical research to bench-to-bedside translation (T1 research) to community implementation (T2 research), and will meet 5 goals: 1) transform the Investigator; 2) transform the Training Environment; 3) transform the Resource Infrastructure; 4) transform the Approach to Interdisciplinary Research via an emphasis on outcomes research and health disparities research; and 5) establish a new Research Model through the Self-Monitoring and Improvement Program. To meet these goals, the CCTS will rely on: 1) a re-organized reporting structure that assures the PI full institutional support in implementing the CCTS roadmap; 2) a revised CCTS leadership that includes faculty from the Schools of Medicine, Public Health, Nursing, Health Professions, and Optometry; and 3) innovative partnerships involving UAB, Southern Research Institute (our affiliated, not-for-profit research organization for preclinical drug discovery/development), the Children's Health System, the HudsonAlpha Institute for Biotechnology, the greater Birmingham community, and a long-standing collaborative network that involves Historically Black Colleges and Universities (HBCUs) and underprivileged communities in our region. UAB, the Health System, Health Services Foundation, Research Foundation, and Southern Research Institute have made substantial commitments to the CCTS including: 1) significant new funding for the clinical and translational research infrastructure (~$150 million, of which over $18 million are directly for CCTS activities and programs); 2) a redesigned and enhanced biomedical informatics infrastructure; and 3) over 20,000 sf of prime clinical and administrative space. When combined, the re-organized CCTS governance and leadership, the substantial commitment of funds and resources, the interdisciplinary culture of UAB, and the new CCTS programs, will create a transformed environment for clinical and translational research that will benefit our trainees, investigators, patients, community, and the national CTSA effort.