CTSA INFRASTRUCTURE FOR CLINICAL TRIALS

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 2007年，阿拉巴马大学伯明翰分校(DAB)及其附属机构完成了三项重要的大规模战略规划工作。这些过程共同产生了“我们研究未来的蓝图”：它为通过跨所有学科、学院和我们的医疗保健系统的整合和创新来转变我们实质性的临床和转化性研究事业奠定了基础。这一转变将由DAB临床和转化科学中心(CCTS)推动。CCTS的愿景是通过教育独创性、监管重组、资源协调和方法创新，建立富有成效和高效的跨学科研究团队，从而改变DAB的环境。其使命是开发一个从临床前研究到工作台到床边转换(T1研究)再到社区实施(T2研究)的变革性基础设施，并将实现5个目标：1)转变研究人员；2)转变培训环境；3)转变资源基础设施；4)通过强调结果研究和健康差异研究来转变跨学科研究的方法；以及5)通过自我监测和改进计划建立新的研究模式。为了实现这些目标，CCTS将依靠：1)重新组织的报告结构，以确保PI在实施CCTS路线图方面获得全面的机构支持；2)修订CCTS领导层，其中包括来自医学院、公共卫生、护理、医疗专业和视光学院的教师；以及3)创新的合作伙伴关系，涉及UAB、南方研究所(我们附属的非营利性临床前药物发现/开发研究组织)、儿童健康系统、Hudson Alpha生物技术研究所、大伯明翰社区，以及涉及本地区历史上的黑人学院和大学(HBCU)和贫困社区的长期合作网络。UAB、卫生系统、卫生服务基金会、研究基金会和南方研究院对CCTS做出了重大承诺，包括：1)为临床和翻译研究基础设施提供大量新资金(约1.5亿美元，其中超过1800万美元直接用于CCTS活动和计划)；2)重新设计和增强生物医学信息学基础设施；以及3)超过20,000 SF的主要临床和行政空间。重新组织的CCTS治理和领导、资金和资源的大量承诺、UAB的跨学科文化以及新的CCTS计划结合在一起，将为临床和转化研究创造一个转变的环境，这将使我们的学员、研究人员、患者、社区和国家CTSA努力受益。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. In 2007, the University of Alabama at Birmingham (DAB) and its affiliates completed three important, large- scale strategic planning efforts. Together, these processes generated a "blueprint for our research future" :hat lays the foundation to transform our substantial clinical and translational research enterprise through ntegration and innovation across all disciplines, Schools, and our health care system. This transformation will be driven by the DAB Center for Clinical and Translational Science (CCTS). The CCTS vision is to transform the DAB environment by building productive and efficient interdisciplinary research teams through educational ingenuity, regulatory reorganization, resource coordination, and methodological innovation. The mission is to develop a transformative infrastructure that spans the spectrum from preclinical research to bench-to-bedside translation (T1 research) to community implementation (T2 research), and will meet 5 goals: 1) transform the Investigator; 2) transform the Training Environment; 3) transform the Resource Infrastructure; 4) transform the Approach to Interdisciplinary Research via an emphasis on outcomes research and health disparities research; and 5) establish a new Research Model through the Self-Monitoring and Improvement Program. To meet these goals, the CCTS will rely on: 1) a re-organized reporting structure that assures the PI full institutional support in implementing the CCTS roadmap; 2) a revised CCTS leadership that includes faculty from the Schools of Medicine, Public Health, Nursing, Health Professions, and Optometry; and 3) innovative partnerships involving UAB, Southern Research Institute (our affiliated, not-for-profit research organization for preclinical drug discovery/development), the Children's Health System, the HudsonAlpha Institute for Biotechnology, the greater Birmingham community, and a long-standing collaborative network that involves Historically Black Colleges and Universities (HBCUs) and underprivileged communities in our region. UAB, the Health System, Health Services Foundation, Research Foundation, and Southern Research Institute have made substantial commitments to the CCTS including: 1) significant new funding for the clinical and translational research infrastructure (~$150 million, of which over $18 million are directly for CCTS activities and programs); 2) a redesigned and enhanced biomedical informatics infrastructure; and 3) over 20,000 sf of prime clinical and administrative space. When combined, the re-organized CCTS governance and leadership, the substantial commitment of funds and resources, the interdisciplinary culture of UAB, and the new CCTS programs, will create a transformed environment for clinical and translational research that will benefit our trainees, investigators, patients, community, and the national CTSA effort.