Neuroscience Advanced Predoctoral institutional Training Grant

神经科学高级博士前机构培训补助金

• 批准号: 9519050
• 负责人: Diane Lipscombe
• 金额: $ 9.39万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9519050
• 关键词: Grant; Neurosciences; Training; pre-doctoral

DESCRIPTION (provided by applicant): The central objective of this advanced predoctoral training program in Neuroscience is to produce graduate students with a high level understanding of the theory, practice, and clinical importance of neural dynamics. Students with appropriate background coursework and research interests will be enrolled in this advanced training plan, a subset of 4 students will receive direct funding from this training grant. Deep knowledge of the basic mechanisms underlying neural dynamics is crucial to understand healthy behavior and many of the profound deficits observed in neurological disease. This topic spans almost all levels of neuroscience inquiry: Biophysics determines patterns of action potential firing, which in turn determines the probability of relay between neurons, and ultimately the information that a neural circuit or distributed representation can carry. Brown University has strong expertise across all these levels, ranging from the genetic bases of neural dynamics underlying behavior through the cognitive neuroscientific study of dynamic control of information processing based on high-level goals. Failures in neural dynamics are widely hypothesized to underlie the pathophysiology of maladies such as epilepsy and Parkinson's disease. The directors, Diane Lipscombe and Chris Moore, have complementary expertise ideal for an Advanced Training Plan in neural dynamics. They will receive advice from external and internal advisory groups and from students, to continue to adapt and improve the training plan. The Neural Dynamics training program will be managed and administered within Brown's Graduate Program in Neuroscience. The Neuroscience Graduate program at Brown offers student-centered, high-quality training and the majority of our graduates pursue careers in neuroscience. Students are also exposed to computational, translational, and clinical approaches. Early multi-disciplinary training dovetails well with this specialized advanced training in Neural Dynamics. This Training Program will provide three basic requirements to produce students with strong training in Neural Dynamics: First, a detailed understanding of the state of knowledge and the defining debates in the study of neural dynamics is required, and will be imparted to students in lectures and seminar courses. This training in basic knowledge will be paired with intensive training in experimental practice to teach students basic principles of scientific design of dynamics studies, and in the cutting edge methods used to resolve debates and test hypotheses in the study of neural dynamics. Students will also design their own experiment(s) on a topic in neural dynamics, and then execute these studies in an intensive 9-day practicum at the Marine Biological Laboratory (MBL). Second, a world-class environment of 29 laboratories investigating this topic at Brown is crucial to foster long-term, in-depth predoctoral research on this topic. Third, access to perspectives beyond those of the home institution, and most importantly beyond classical academia itself, will expand students' understanding and perspective on this important topic.

描述（由申请人提供）：这个先进的神经科学博士前培训计划的中心目标是培养对神经动力学的理论，实践和临床重要性有高度理解的研究生。具有适当背景课程和研究兴趣的学生将参加该高级培训计划，4名学生的子集将获得该培训补助金的直接资助。深入了解神经动力学的基本机制对于理解健康行为和在神经系统疾病中观察到的许多深刻缺陷至关重要。这个主题几乎涵盖了神经科学研究的所有层面：生物物理学决定了动作电位放电的模式，这反过来又决定了神经元之间中继的概率，最终 神经回路或分布式表示可以携带的信息。布朗大学 所有这些层面的强大专业知识，从神经动力学的遗传基础到基于高层次目标的信息处理动态控制的认知神经科学研究。神经动力学的故障被广泛假设为癫痫和帕金森病等疾病的病理生理学基础。导演黛安·利普斯科姆和克里斯·摩尔拥有互补的专业知识，非常适合神经动力学的高级培训计划。他们将从外部和内部咨询小组以及学生那里获得建议，以继续调整和改进培训计划。神经动力学培训计划将在布朗的神经科学研究生课程中管理和实施。布朗大学的神经科学研究生课程提供以学生为中心的高质量培训，我们的大多数毕业生都从事神经科学的职业。学生还接触到计算，翻译和临床方法。早期的多学科培训与神经动力学的这种专门的高级培训相吻合。该培训计划将提供三个基本要求，以培养学生在神经动力学方面的强大培训：首先，需要详细了解知识状态和神经动力学研究中的定义辩论，并将在讲座和研讨会课程中传授给学生。这种基础知识的培训将与实验实践中的强化培训相结合，以教授学生动力学研究科学设计的基本原则，以及用于解决神经动力学研究中的争论和测试假设的尖端方法。学生还将设计自己的神经动力学主题实验，然后在海洋生物实验室（MBL）进行为期9天的密集实习。其次，布朗大学拥有29个实验室，这些实验室都是世界一流的环境，对促进这一主题的长期深入的博士前研究至关重要。第三，获得超越家庭机构的观点，最重要的是超越经典学术界本身，将扩大学生对这一重要主题的理解和观点。