The Colorado Building Interdisciplinary Research Careers in Women's Health Program

项目摘要 此应用程序是为科罗拉多建设跨学科研究职业生涯的第三个周期的资金， 2007年设立的妇女健康研究K12方案。近10年来，我们 在该计划中有14名学者，其中12人留在学术医学，11人获得了 外部资助（3个尚未资助的学者中有2个是最近的学者），他们集体产生了超过 90篇出版物（不包括摘要）。对于我们提议的第三个周期， BIRCWH的周期，我们提出了几个关键的计划创新：1）添加一个经过验证的研究和职业生涯 开发课程的计划（取代旧课程），同时确保没有中断 学者研究时间。2)将精准医疗作为重点领域，从而提供一个前沿、交叉的 切割主题，这将有助于交织在一起，我们的重点。3)学者们将写下他们的第一个个人K奖 时间早（在第8 - 9个月的BIRCWH学者的任命）比往年。在我们的试点测试中， 这种方法，在选择过程中没有任何变化，目前BIRCWH学者获得 个人外部融资的成功率越来越高。4)完成后继续使用SAC BIRCWH奖学金期间（如果个人K是下一步或通过写R）提供持续的 在职业发展阶段提供指导，同时建立独立性。事实证明， 帮助学者进步。5)与Shanta齐默，医学博士，新的副院长， 多样性，使用新的UC-SOM计划增加BIRCWH学者的多样性，6）增加 生物统计学的可用性，以满足学者的复杂的统计需求。我们的具体目标是： 支持来自全国各地的优秀人才库中的3名顶尖申请人，并提供 为他们提供量身定制的高质量跨学科指导研究经验;提供 来自医学和妇产科内外的优秀导师的学者，包括 心脏病学、内分泌学、流行病学、免疫学、综合生理学、分子生物学、 儿科，精准医学和精神病学等，他们都是资深科学家， 资金和培训的跟踪记录，并培养跨学科的团队科学家准备解决关键问题， 妇女健康和性别差异的研究问题。我们的内部计划咨询委员会将 继续评估计划的运作和进展;我们的外部计划咨询委员会将 提供一个局外人对BIRCWH的概述，以确保我们跟上妇女发展的国家趋势， 健康和性别差异研究。为科罗拉多州儿童福利和健康研究中心提供的出色的机构支持，包括 妇女健康研究中心和其他支持BIRCWH的团体也将推动这一增长。 一个重要的计划，旨在发展成功的，独立的科学家跨学科的职业生涯， 研究女性健康与性别差异，从而提高女性的健康水平。

Project Summary This application is for the 3rd cycle of funding for the Colorado Building Interdisciplinary Research Careers in Women’s Health Research (BIRCWH) K12 program, established in 2007. Over the past almost 10 years, we have had 14 Scholars in the program, 12 of whom have remained in academic medicine, 11 have received external funding (2 of the 3 not yet funded are more recent Scholars) and who collectively have produced over 90 publications (not including abstracts). For our proposed third cycle, learning from our experience in two prior cycles of BIRCWH, we propose several key program innovations: 1) Adding a proven research and career development curriculum to the program (replacing old curriculum) while ensuring that there is no disruption of Scholar research time. 2) Adding Precision Medicine as a focus area, thus providing a cutting edge, cross- cutting theme that will serve to interweave our foci together. 3) Scholars will write their first individual K award earlier in time (in the 8th-9th month of a BIRCWH Scholar’s appointment) than in prior years. In our pilot test of this approach, without any change in the selection process, current BIRCWH Scholars are obtaining individual external funding with increasing rates of success. 4) Continued use of SAC following completion of BIRCWH Scholar period (if an individual K is the next step or through writing the R) to provide ongoing guidance through the career development period while establishing independence. This has proven to be very successful in helping Scholars progress. 5) Working with Shanta Zimmer, MD, new Associate Dean for Diversity, to increase diversity of BIRCWH Scholars using the new UC-SOM plan and 6) Increased biostatistian availability to meet the complex statistical needs of the Scholars. Our specific aims are to: Support 3 top applicants from a national pool of exceptionally motivated and talented individuals, and provide them with an appropriately tailored, top-quality interdisciplinary mentored research experience; Provide Scholars with outstanding mentors from within and without the departments of Medicine and Ob/Gyn, including expertise in Cardiology, Endocrinology, Epidemiology, Immunology, Integrative Physiology, Molecular Biology, Pediatrics, Precision Medicine and Psychiatry, among others, all of whom are senior scientists with strong track records of funding and training, and nurture interdisciplinary team scientists poised to address key research problems in women’s health and sex differences. Our Internal Program Advisory Committee will continue to evaluate program operations and progress; our External Program Advisory Committee which will provide an outsider’s overview of the BIRCWH to assure that we stay abreast of national trends in women’s health and sex difference research. The excellent institutional support for the Colorado BIRCWH, including the Center for Women’s Health Research and other groups that support BIRCWH, will also fuel the growth of this important program which aims to develop successful, independent interdisciplinary careers of scientists in women’s health and sex differences research and thereby improve the health of women.