Mechanisms of Membrane Transport GRC 2019

膜传输机制 GRC 2019

• 批准号: 9761723
• 负责人: Olga Boudker
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9761723
• 关键词: Academia; Affect; Brain; Career Choice; Carrier Proteins; Cell Survival; Cell membrane; Cells; Cellular Membrane; Cryoelectron Microscopy; Crystallography; Development; Disease; Ensure; Environment; Epilepsy; Evolution; Financial Support; Fostering; Functional disorder; Future; Health; Heart; Human; Human body; Individual; Ion Channel; Link; Lipid Bilayers; Mediating; Membrane; Membrane Proteins; Membrane Transport Proteins; Mental disorders; Mentors; Methods; Mission; Molecular; Motion; Movement; Mutation; Myocardial dysfunction; Nerve Degeneration; Organism; Pathologic; Pathology; Pharmacology; Physiological; Physiology; Postdoctoral Fellow; Protein Dynamics; Proteins; Research; Research Personnel; Role; Running; Sampling; Scientist; Seasons; Senior Scientist; Series; Sex Bias; Shapes; Structure; Students; Training; Transmembrane Transport; United States National Institutes of Health; Work; addiction; base; biophysical techniques; body system; career; cohort; experimental study; graduate student; insight; intercellular communication; kidney dysfunction; meetings; nervous system disorder; neurotransmission; novel therapeutics; physical property; posters; programs; protein folding; protein function; protein metabolism; protein transport; recruit; symposium

Project Summary The Mechanisms of Membrane Transport GRC has been running since 1966. The mission of the GRC is to advance the understanding of ion channels and transporters at the structural, mechanistic and physiological levels. The channels and transporters are fundamental to the physiology of all cells and organisms and their dysfunction is associated with numerous diseases affecting every organ system in the human body. They are of particular importance in the brain, where they mediate all aspects of neurotransmission. Even subtle dysregulation of these proteins due to mutations or pathological conditions leads to devastating human conditions such as epilepsy, neurodegeneration, addiction, and mental disorders. In depth understanding of their mechanisms opens novel therapeutic strategies and increases their utility as pharmacological targets. The 2019 GRC, subtitled “From evolution and folding to new concepts in health and disease” aims to generate vigorous discussions with a specific emphasis on exploring avenues of rigorous mechanistic studies of membrane transport proteins within the context of their physiologic environments and in view of their specific roles in cells. The GRC also aims to provide an effective forum promoting junior researchers and facilitating their career choices. A Gordon Research Seminar will run in conjuncture with the GRC, organized by junior investigators and trainees during the preceding two days. 2019 GRS will serve to promote scientific research by junior attendees and to further NIH training priorities through discussions of career options and strategies, and of gender biases in academia. !

项目摘要 膜转运机制GRC自1966年以来一直在运行。的使命 该研究中心的目的是促进对离子通道和转运蛋白的理解， 机制和生理水平。通道和转运体是 所有细胞和生物体的生理学及其功能障碍与许多 影响人体每个器官系统的疾病。它们在以下方面特别重要： 它们在大脑中调节神经传递的各个方面。即使是轻微的失调， 这些蛋白质由于突变或病理条件导致毁灭性的人类 癫痫、神经变性、成瘾和精神障碍等病症。深入 对它们的机制的理解开辟了新的治疗策略，并增加了它们的效用 作为药理学靶点。2019年GRC，副标题为“从进化和折叠到新的 健康与疾病的概念”旨在引起积极的讨论， 探索膜转运蛋白的严格机制研究的途径， 它们的生理环境背景和鉴于它们在细胞中的特定作用。集团风险管理委员会 还旨在提供一个有效的论坛，促进初级研究人员和促进他们的职业生涯 选择.一个戈登研究研讨会将运行在与GRC结合，由初级组织 前两天的调查人员和学员。2019年GRS将致力于促进 科学研究的初级与会者，并通过讨论进一步NIH培训的优先事项 职业选择和战略，以及学术界的性别偏见。 !