Pilot Project 1: Mexican immigrants' biological and behavioral cancer risk based on stress

试点项目 1：基于压力的墨西哥移民生物和行为癌症风险

• 批准号: 9761483
• 负责人: Daphne C. Hernandez
• 金额: $ 2.63万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9761483
• 关键词: Acculturation; Adult; Adverse event; Affect; Alcoholism; American; Area; Behavioral; Biological; Biological Markers; Body fat; Body mass index; Cancer Center; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cessation of life; Childhood; Chronic; Chronic stress; Collaborations; Collection; Communities; Competence; Country; Data; Data Analyses; Development; Diabetes Mellitus; Discrimination; Elderly; Enrollment; Equipment and supply inventories; Ethnic Origin; Exposure to; Fright; Goals; Hand; Health; Health Care Costs; Health Status; Health behavior; Hispanics; Human Development; IL8 gene; Immigrant; Individual; Inflammatory; Interdisciplinary Study; Interleukin-6; Intervention; Language; Lead; Life Cycle Stages; Malignant Neoplasms; Measures; Mexican; Mexican Americans; Minority; Modeling; Not Hispanic or Latino; Obesity; Outcome; Pathway interactions; Physiological; Pilot Projects; Population; Poverty; Prevention; Prevention strategy; Process; Publishing; Reporting; Research; Research Design; Risk; Risk Factors; SECTM1 gene; Sex Behavior; Stigmatization; Stress; Surveys; TNF gene; Time; United States National Institutes of Health; Universities; University of Texas M D Anderson Cancer Center; adverse childhood events; aged; base; behavior influence; behavior measurement; behavioral response; behavioral study; biological adaptation to stress; biological systems; cancer health disparity; cancer prevention; cancer risk; childhood adversity; community center; cytokine; design; disorder risk; ethnic minority population; experience; individual variation; innovation; insight; peer; pressure; programs; racial and ethnic; social; social stress; stressor; theories; waist circumference

PROJECT SUMMARY/ABSTRACT Despite the 11.4 million Mexican immigrants living in the U.S., the biological and behavioral determinants that contribute to cancer disparities among them are vastly understudied. While research has indicated that adverse childhood experiences (ACE) influence cancer in adulthood, this association has not been investigated among Mexican immigrants. In addition, exposure to minority stress is associated with poor physical adult health outcomes. This association is particularly important for Mexican immigrants, as they are exposed to a disproportionate number of stressors associated with their minority status that are stigmatizing and discriminatory. It is believed that minority-related stressors are unique (i.e., not experienced by non- stigmatized populations), additive, chronic, and socially based. The repeated or chronic stress of ACE, such as living in poverty, or ongoing adult experiences associated with minority stress, such as pressure to acculturate, can lead to dysregulation of biological systems and harmful health behaviors. Biological and behavioral stress responses, such as the presence of pro-inflammatory cytokines, elevated adiposity, alcoholism, and risky sexual activity are associated with cancer development in adulthood. The goal of this study is to evaluate the association of ACE, minority stress and their combination with cancer risk factors among Mexican immigrants. This study will pursue three primary aims: (1) Evaluate cancer risk factors in relation to the adversity that occurred in childhood; (2) Evaluate cancer risk factors in adulthood in relation to minority stress; and (3) Determine the extent to which biological and behavioral cancer risk factors increase as a result of the additive effect of ACE and minority stress in adulthood. This proof-of-concept study will enroll 50 Mexican immigrants (aged 19-49 years) who reside in the Houston area. The ACE survey will be used to retrospectively measure stress during childhood, and the Multidimensional Acculturative Stress Inventory (MASI) will be used to measure minority stress. Direct assessment will be used to measure 11 pro-inflammatory cytokines (e.g., IL-6, IL-8, and TNFα) and three adiposity measures (body mass index, body fat percentage, and waist circumference).This study is highly innovative for three primary reasons: (1) It focuses on a population that experiences cancer disparities but is rarely included in interdisciplinary research; (2) It uses an interdisciplinary framework that embeds Cumulative Risk Theory and Minority Stress Theory into a Life Course Perspective to understand the impact of social stress on cancer risk; and (3) It uses multiple biological and behavioral measurements to provide a more complete understanding of how stress influences cancer risk. It is envisioned that this study will expand an interdisciplinary research program aimed at investigating biological and behavioral influences on cancer risk factors. The findings from the proof-of-concept study will be used to help design a larger scale study that will advance research and modify cancer prevention strategies.

项目总结/摘要 尽管有1140万墨西哥移民居住在美国，生物和行为决定因素， 导致癌症的差异在他们中间被大大低估。虽然研究表明， 儿童期经历（ACE）影响成年期癌症，这种关联尚未在 墨西哥移民。此外，暴露于少数民族的压力与身体健康不良的成年人 结果。这种联系对墨西哥移民来说尤其重要，因为他们接触到的是一种 与其少数群体地位相关的压力因素过多， 歧视据信，与少数群体有关的压力源是独特的（即，没有经历过非- 污名化的人群），添加剂，慢性和社会基础。ACE的重复或慢性压力，例如 生活贫困，或与少数群体压力有关的持续成年经历，如文化适应压力， 可能导致生物系统失调和有害健康的行为。生物和行为压力 反应，如促炎细胞因子的存在，肥胖，酗酒和危险的性行为 活动与成年期癌症的发展有关。本研究的目的是评估 ACE，少数民族压力及其与墨西哥移民癌症风险因素的结合。 这项研究将追求三个主要目标：（1）评估与逆境有关的癌症风险因素， 发生在儿童时期;（2）评估成年期与少数民族压力有关的癌症风险因素;（3） 确定生物和行为癌症风险因素因添加剂而增加的程度 ACE和少数民族压力在成年期影响。这项概念验证研究将招募50名墨西哥移民 (aged 19-49岁，居住在休斯顿地区。ACE调查将用于回顾性测量 多元文化压力量表（Multidimensional Aculturative Stress Inventory，马西） 测量少数民族的压力直接评估将用于测量11种促炎细胞因子（例如，IL-6， IL-8和TNFα）和三项肥胖指标（体重指数、体脂百分比和腰围 这项研究具有高度的创新性，主要有三个原因：（1）它关注的人群， 经历癌症差异，但很少包括在跨学科研究中;（2）它使用一个 将累积风险理论和少数压力理论嵌入生活的跨学科框架 课程观点，以了解社会压力对癌症风险的影响;（3）它使用多种生物学 和行为测量，以更全面地了解压力如何影响癌症风险。 据设想，这项研究将扩大一个跨学科的研究计划，旨在调查 生物和行为对癌症危险因素的影响。概念验证研究的结果将是 用于帮助设计一个更大规模的研究，将推进研究和修改癌症预防策略。