FASEB SRC on Helicases and nucleic acid-based machines: Structure, mechanism, regulation, and roles in human diseasesg

项目摘要摘要 这个应用程序请求支持2019年的科学研究会议“解旋酶和 基于核酸的机器：结构、机制、调节和在人类中的作用 疾病“。这次会议由美国实验学会联合会主办 生物学(FASE B)，将于2019年7月21日至26日在科罗拉多州蒸汽船斯普林斯举行。这个 会议由里克·拉塞尔(美国得克萨斯大学奥斯汀分校)、罗伯特·布罗什(NIA- 美国巴尔的摩国立卫生研究院)和德国维尔茨堡大学卡罗琳·基斯克。 DNA和RNA的一个决定性的性质是它的碱基对的稳定性，因此解旋酶 酶是各种核酸加工机不可或缺的组成部分。他们的 解开DNA和RNA以及重塑蛋白质-核酸复合体的活动， 是核酸代谢的每一步以及从DNA到RNA的信息传递的基础 蛋白质。这些酶的缺陷与多种人类疾病有关。 包括癌症和早衰。 解旋酶在DNA复制、修复、重组和基因调控中的关键作用 在许多疾病中的表达及其失调，以及实验方法的广度 需要在研究这一问题的不同科学家群体之间进行强有力的信息交换 结构、调节、分子和细胞功能以及与以下相关的疾病过程 解旋酶。第11届解旋酶和基于核酸的机器的双年度会议将解决这一问题 需要。会议的科学主题将从深化结构和功能研究 我们对解旋酶发挥作用的基本原理的了解一直到解旋酶如何 有助于关键的基于核酸的机器的功能以及这种知识如何 被用来改善人类健康。有了这样的重点和范围，这次会议具有独特的价值 研究人员研究一系列生物过程。专业人士的创新模式 面向科学界女性和年轻研究人员的发展会议也将提供 为这些群体提供有价值的服务。总体而言，会议的组织将是为了促进 跨科学领域以及在现有和新的科学领域之间高效地交换思想和信息 解旋酶结构、机制、调节和在人类疾病中作用的所有领域的研究人员。

Project Summary Abstract This application requests support for the 2019 science research conference on “Helicases and Nucleic acid-based machines: Structure, mechanism, regulation, and roles in human diseases”. The meeting is sponsored by the Federation of American Societies for Experimental Biology (FASEB) and will take place from July 21-26, 2019, in Steamboat Springs, Colorado. The conference is being organized by Rick Russell (University of Texas, Austin, USA), Robert Brosh (NIA- NIH, Baltimore, USA), and Caroline Kisker (University of Würzburg, Germany). A defining property of DNA and RNA is the stability of its base pairs, and consequently helicase enzymes are integral components of a wide range of nucleic acid processing machines. Their activities in unwinding DNA and RNA, as well as in remodeling protein-nucleic acid complexes, underlie every step of nucleic acid metabolism and the transfer of information from DNA to RNAs and proteins. Defects in these enzymes are associated with a broad spectrum of human diseases including cancer and premature aging. The critical roles of helicases in the regulation of DNA replication, repair, recombination and gene expression and their dysregulation in many diseases, and the breadth of the experimental approaches requires a robust exchange of information among the diverse group of scientists studying the structure, regulation, molecular and cellular functions, and disease-processes associated with helicases. The 11th bi-annual meeting on helicases and nucleic acid-based machines will address this need. The scientific topics at the meeting will range from structural and functional studies that deepen our knowledge of the basic principles through which helicases function all the way to how helicases contribute to the functions of key nucleic acid-based machines and how this knowledge can be exploited to improve human health. With this focus and range, this meeting has unique value for researchers studying a range of biological processes. An innovative format for professional development sessions geared towards women in science and young investigators will also provide a valuable service for these groups. Overall, the meeting will be organized to promote robust and efficient exchange of ideas and information across scientific areas and between established and new investigators in all areas of helicase structure, mechanism, regulation, and roles in human diseases.