FASEB SRC on Helicases and nucleic acid-based machines: Structure, mechanism, regulation, and roles in human diseasesg

FASEB SRC 关于解旋酶和核酸机器：结构、机制、调节和在人类疾病中的作用g

• 批准号: 9762387
• 负责人: Rick Russell
• 金额: $ 0.45万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762387
• 关键词: Address; Aging; American; Animal Model; Area; Baltimore; Base Pairing; Binding Proteins; Biochemical; Biological; Biological Process; Biology; Biophysics; Bloom Syndrome; Caring; Cell physiology; Cells; Child; Clustered Regularly Interspaced Short Palindromic Repeats; Cockayne Syndrome; Collaborations; Colorado; Complex; Crohn' s disease; DNA; DNA Repair; DNA biosynthesis; Defect; Development; Diagnosis; Disabled Persons; Disease; Dyskeratosis Congenita; Electronic Mail; Ensure; Enzymes; Eye; Family; Fanconi' s Anemia; Fees; Fostering; Functional disorder; Gene Expression; Genetic; Genetic Diseases; Genetic Recombination; Genome Stability; Genomic Instability; Germany; Goals; Health; Homeostasis; Housing; Human; In Vitro; Information Technology; Journals; Knowledge; Learning; Link; Logistics; Malignant Neoplasms; Mentors; Molecular; Molecular Conformation; Molecular Machines; Molecular Motors; Nature; Newsletter; Nucleic Acids; Nucleotides; Ophthalmoplegia; Participant; Pathway interactions; Phenotype; Physiological; Predisposition; Premature aging syndrome; Process; Property; Proteins; Publishing; RNA; RNA Helicase; RNA Interference; RNA Splicing; RNA Transport; Regulation; Request for Applications; Research; Research Personnel; Resort; Resources; Role; Rothmund-Thomson syndrome; Science; Scientific Societies; Scientist; Services; Site; Site-Directed Mutagenesis; Societies; Structural Protein; Structure; Substrate Specificity; Syndrome; System; Techniques; Texas; Time; Trichothiodystrophy; Underrepresented Groups; Underrepresented Minority; United States National Institutes of Health; Universities; Werner Syndrome; Woman; Xeroderma Pigmentosum; age related; austin; base; collaborative environment; graduate student; helicase; human disease; improved; in vivo; innovation; live cell imaging; meetings; nucleic acid metabolism; nucleoside triphosphatase; posters; programs; protein structure; reconstitution; repaired; single molecule; small molecule; symposium; therapeutic development; training opportunity

Project Summary Abstract This application requests support for the 2019 science research conference on “Helicases and Nucleic acid-based machines: Structure, mechanism, regulation, and roles in human diseases”. The meeting is sponsored by the Federation of American Societies for Experimental Biology (FASEB) and will take place from July 21-26, 2019, in Steamboat Springs, Colorado. The conference is being organized by Rick Russell (University of Texas, Austin, USA), Robert Brosh (NIA- NIH, Baltimore, USA), and Caroline Kisker (University of Würzburg, Germany). A defining property of DNA and RNA is the stability of its base pairs, and consequently helicase enzymes are integral components of a wide range of nucleic acid processing machines. Their activities in unwinding DNA and RNA, as well as in remodeling protein-nucleic acid complexes, underlie every step of nucleic acid metabolism and the transfer of information from DNA to RNAs and proteins. Defects in these enzymes are associated with a broad spectrum of human diseases including cancer and premature aging. The critical roles of helicases in the regulation of DNA replication, repair, recombination and gene expression and their dysregulation in many diseases, and the breadth of the experimental approaches requires a robust exchange of information among the diverse group of scientists studying the structure, regulation, molecular and cellular functions, and disease-processes associated with helicases. The 11th bi-annual meeting on helicases and nucleic acid-based machines will address this need. The scientific topics at the meeting will range from structural and functional studies that deepen our knowledge of the basic principles through which helicases function all the way to how helicases contribute to the functions of key nucleic acid-based machines and how this knowledge can be exploited to improve human health. With this focus and range, this meeting has unique value for researchers studying a range of biological processes. An innovative format for professional development sessions geared towards women in science and young investigators will also provide a valuable service for these groups. Overall, the meeting will be organized to promote robust and efficient exchange of ideas and information across scientific areas and between established and new investigators in all areas of helicase structure, mechanism, regulation, and roles in human diseases.

项目摘要 此应用程序请求支持2019年科学研究会议“解旋酶和 基于核酸的机器：结构，机制，调节和在人类中的作用 疾病”。这次会议是由美国实验动物学会联合会主办的。 生物学（FASEB），将于2019年7月21日至26日在科罗拉多的汽船泉举行。的 会议由里克·罗素（德克萨斯大学，奥斯汀，美国），罗伯特·布罗什（NIA- NIH，巴尔的摩，美国）和Caroline基斯克（维尔茨堡大学，德国）。 DNA和RNA的一个决定性特性是其碱基对的稳定性，因此解旋酶也是如此。 酶是各种核酸加工机器的组成部分。他们的 在解旋DNA和RNA中的活性，以及在重塑蛋白质-核酸复合物中的活性， 是核酸代谢的每一步以及从DNA到RNA的信息传递的基础， proteins.这些酶的缺陷与多种人类疾病有关 包括癌症和早衰 解旋酶在DNA复制、修复、重组和基因调控中的重要作用 在许多疾病中的表达及其失调，以及实验方法的广度 需要研究该领域的不同科学家群体之间进行强有力的信息交换 结构，调节，分子和细胞功能，以及与 解旋酶第11届解旋酶和基于核酸的机器会议将解决这一问题 需要的会议的科学主题将包括结构和功能研究， 我们对解旋酶的基本原理的了解， 有助于关键的基于核酸的机器的功能，以及如何将这些知识 用来改善人类健康有了这一重点和范围，本次会议具有独特的价值， 研究一系列生物过程的研究人员。一种创新的专业格式 面向科学界女性和年轻研究人员的发展会议也将提供一个 为这些群体提供了宝贵的服务。总的来说，会议的组织将促进强有力的和 跨科学领域以及新旧科学家之间有效交流思想和信息 解旋酶结构、机制、调节和在人类疾病中的作用的所有领域的研究人员。