Host and bacterial enzyme-mediated approaches to produce durable direct and indirect restorations
宿主和细菌酶介导的方法产生持久的直接和间接修复
基本信息
- 批准号:9765078
- 负责人:
- 金额:$ 49.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-03-01 至 2020-02-29
- 项目状态:已结题
- 来源:
- 关键词:AddressAdhesivesAffectAgeAmidesAmmoniumAnti-Bacterial AgentsAntibioticsBacteriaBinding SitesBiocompatible MaterialsBioreactorsCapsid ProteinsCatalytic DomainCell Membrane ProteinsChelating AgentsChlorhexidineClinicalCohort StudiesCollagenComposite ResinsDentalDental MaterialsDental cariesDental crownsDentinDiseaseEcologyEndocarditisEnvironmentEnzymesEstheticsFractureGelatinase AGeneral PopulationGlucansGlucoseGram-Positive BacteriaHealthcareHybridsHydrolysisImmobilizationInfectionKineticsLongevityMaterials TestingMatrix MetalloproteinasesMechanicsMediatingMetabolicMethacrylatesMicrobial BiofilmsModelingMouthwashNatureNitro CompoundsOralOral PathologyOral cavityOrganismPathogenicityPatientsPenetrationPeriodontal DiseasesPhysiologicalPlant ResinsPolymersPolysaccharidesPopulationPreventionProceduresProductionPropertyPublic HealthReactionRecurrenceResistanceRetreatmentRiskSalivaSpecificityStreptococcus gordoniiStreptococcus mutansStructureSurfaceSystemTechnologyTestingTimeTissuesTooth structureToothpasteTranslationsTriclosanUnderserved PopulationWateraging populationanalogantimicrobialantimicrobial drugbactericidebasecancer therapycollagenasecommensal bacteriacomposite restorationdesigndysbiosisesteraseextracellularglycosyltransferaseimprovedinhibitor/antagonistmechanical loadmechanical propertiesmethacrylamidemicrobialmonomernoveloral bacteriapolymerizationpreservationpreventrestorationrestorative compositerestorative materialsmall molecule
项目摘要
Summary
Dental caries continues to be a public health issue, especially more evident in underserved
populations throughout the U.S. Unfortunately, especially with an ageing population, hundreds
of thousands of resin composite restorations are replaced each year due to recurring decay and
fracture. According to a number of cohort studies, the average life-span of this type of
restoration is 10 years or less, depending on the caries risk level of the patient and on the
complexity of the restorative procedure. This proposal represents an effort to develop novel
antimicrobial structures, based on a targeted approach specifically against dysbiotic biofilm.
Bacterial coalescence will be prevented by using GTF inhibitors, made polymerizable by
functionalization with stable methacrylamides. In addition, MMP-inhibiting moieties will be added
to a polymerizable monomer, improving the stability of the collagen in the hybrid layer.
Ultimately, this will save millions of dollars annually and the unnecessary loss of additional tooth
structure that comes with every re-treatment. The proposed approach will improve the longevity
of restorations by: 1. Designing monomers containing known GTF-inhibiting moieties, thus
making them available non-transiently at the surface of restorations. 2.Utilizing polymerizable
functionalities that depart from the water/esterase-labile methacrylates. Methacrylamides are
well known for their resistance to degradation by hydrolysis, and the systems proposed here will
also be stable to enzymatic attack. 3. Incorporating MMP-inhibiting moieties on the
methacrylamide monomer to the used as the adhesive, thus preserving the integrity of the
collagen long-term. 4. Testing the materials in a physiologically relevant environment, mimicking
the conditions in the mouth in terms of mechanical loading, bacterial challenge and presence of
saliva.
总结
龋齿仍然是一个公共卫生问题,特别是在服务不足的地区,
不幸的是,特别是随着人口老龄化,数百人
每年有成千上万的树脂复合材料制品因反复腐烂而被更换,
骨折根据一些队列研究,这类人的平均寿命
修复期为10年或更短,取决于患者的龋齿风险水平和
恢复性程序的复杂性。该提案代表了一种努力,
抗微生物结构,基于专门针对微生态生物膜的靶向方法。
细菌聚结将通过使用GTF抑制剂来防止,所述GTF抑制剂通过
用稳定的甲基丙烯酰胺官能化。此外,将添加MMP抑制部分,
与可聚合单体结合,从而提高混合层中胶原的稳定性。
最终,这将节省数百万美元,每年和不必要的损失额外的牙齿
每一次再治疗都会带来的结构。所提出的方法将提高寿命
1.设计含有已知GTF抑制部分的单体,因此
使得它们在双折射表面上非瞬时地可用。2.利用可聚合
这些官能团与水/酯酶不稳定的甲基丙烯酸酯不同。甲基丙烯酰胺是
众所周知,它们对水解降解的抵抗力,这里提出的系统将
对酶的攻击也是稳定的。3.将MMP-抑制部分置于
将甲基丙烯酰胺单体用作粘合剂,从而保持粘合剂的完整性。
长期胶原蛋白。4.在生理相关环境中测试材料,模仿
口腔中的条件,包括机械负荷、细菌挑战和
口水
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Carmem S. Pfeifer其他文献
Properties of resin composites containing natural antimicrobial components
含有天然抗菌成分的树脂复合材料的性能
- DOI:
10.1016/j.dental.2015.08.066 - 发表时间:
2015 - 期刊:
- 影响因子:5
- 作者:
C. B. André;P. Rosalen;Carmem S. Pfeifer;M. Giannini;J. Ferracane - 通讯作者:
J. Ferracane
Effectiveness of high irradiance for short-time exposures on polymerization of composite under metal brackets.
短时间暴露的高辐照度对金属支架下复合材料聚合的有效性。
- DOI:
10.2319/051817-338.1 - 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
A. Faria;D. Covell;J. Ferracane;Carmem S. Pfeifer - 通讯作者:
Carmem S. Pfeifer
Influence of the base and diluent monomer on network characteristics and mechanical properties of neat resin and composite materials
基础单体和稀释单体对纯树脂及复合材料网络特性和力学性能的影响
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:0
- 作者:
Nívea Regina Godoy Fróes;Vinícius Gajewski;B. P. Ornaghi;Carmem S. Pfeifer;M. Meier;T. Xavier;R. Braga - 通讯作者:
R. Braga
Current approaches to produce durable biomaterials: Trends in polymeric materials for restorative dentistry applications
- DOI:
10.1016/j.dental.2024.10.004 - 发表时间:
2024-12-01 - 期刊:
- 影响因子:
- 作者:
Carmem S. Pfeifer;Fernanda S. Lucena;Matthew G. Logan;Devatha Nair;Steven H. Lewis - 通讯作者:
Steven H. Lewis
Commentary: polymerization stress: does it really impact the longevity of composite restorations?
评论:聚合应力:它真的会影响复合材料修复体的寿命吗?
- DOI:
- 发表时间:
2013 - 期刊:
- 影响因子:3.2
- 作者:
Carmem S. Pfeifer - 通讯作者:
Carmem S. Pfeifer
Carmem S. Pfeifer的其他文献
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{{ truncateString('Carmem S. Pfeifer', 18)}}的其他基金
Novel polymeric materials with improved durability in the oral environment: tailoring responses to host and bacterial enzymes with anti-proteolytic and ecology-based antimicrobial approaches.
在口腔环境中具有更高耐用性的新型聚合物材料:通过抗蛋白水解和基于生态的抗菌方法定制对宿主和细菌酶的反应。
- 批准号:
10443658 - 财政年份:2019
- 资助金额:
$ 49.5万 - 项目类别:
Novel polymeric materials with improved durability in the oral environment: tailoring responses to host and bacterial enzymes with anti-proteolytic and ecology-based antimicrobial approaches.
在口腔环境中具有更高耐用性的新型聚合物材料:通过抗蛋白水解和基于生态的抗菌方法定制对宿主和细菌酶的反应。
- 批准号:
10653700 - 财政年份:2019
- 资助金额:
$ 49.5万 - 项目类别:
Novel polymeric materials with improved durability in the oral environment: tailoring responses to host and bacterial enzymes with anti-proteolytic and ecology-based antimicrobial approaches.
在口腔环境中具有更高耐用性的新型聚合物材料:通过抗蛋白水解和基于生态的抗菌方法定制对宿主和细菌酶的反应。
- 批准号:
10228724 - 财政年份:2019
- 资助金额:
$ 49.5万 - 项目类别:
Novel dental composites based on methacrylamides and thiourethane oligomers
基于甲基丙烯酰胺和硫氨酯低聚物的新型牙科复合材料
- 批准号:
9109968 - 财政年份:2016
- 资助金额:
$ 49.5万 - 项目类别:
Thiourethanes as low-stress modifiers in dental composites
硫代氨基甲酸酯作为牙科复合材料中的低应力改性剂
- 批准号:
8574051 - 财政年份:2013
- 资助金额:
$ 49.5万 - 项目类别:
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