Neuroscience-informed Treatment Development for Adolescent Alcohol Use Disorders

青少年酒精使用障碍的神经科学治疗方法开发

基本信息

  • 批准号:
    9764215
  • 负责人:
  • 金额:
    $ 20.08万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-20 至 2021-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Relevance: Adolescent alcohol use is problematic and has long-term negative cognitive and social consequences. Decreasing substance use at this early stage could have significant long-term benefits to psychosocial outcomes and deter progression to habitual use; however, efforts to prevent or decrease alcohol use during adolescence have only been modestly effective, and pharmacotherapy research focused on adolescent alcohol use has been sparse. Evaluation of alternative and more efficacious treatments for adolescent alcohol users is warranted. Description: N-acetylcysteine (NAC) is an over-the-counter antioxidant supplement with glutamatergic properties that has shown promise in treating marijuana dependence in adolescents. Preclinical findings suggest NAC works through restoring glutamate homeostasis disrupted by addiction, a finding replicated across multiple substances of abuse. No published clinical trials to date have examined the efficacy of NAC on alcohol use. This is surprising, given previous promising NAC findings in marijuana-dependent adolescents and the safety, tolerability, and affordability of this over-the-counter supplement. This K23 application proposes to examine the effects of NAC on alcohol cue reactivity, adolescent glutamatergic systems, and drinking behaviors in a randomized, double-blind, placebo-controlled within-subjects crossover study. In counterbalanced order, 40 participants will receive a 10-day course of NAC 1200 mg twice daily and a subsequent 10-day course of matched placebo twice daily, separated by washout period. Human laboratory and imaging procedures will be conducted at baseline and after each course of medication treatment to clarify NAC's effect on glutamatergic systems and alcohol cue reactivity. Functional magnetic resonance imaging (fMRI) will examine alcohol reactivity and magnetic resonance spectroscopy will examine glutamate levels in the anterior cingulate after NAC versus placebo over the same interval. Aims: This proposal provides optimal training for the applicant to gain expertise in substance use disorder clinical trials research, evidence based treatments for adolescent substance users, and magnetic resonance spectroscopy methods and analysis needed to conduct independent, patient-oriented, developmental research on neural mechanisms associated with adolescent substance use and treatment. Findings from this study will help establish if NAC could be a promising treatment for adolescent substance users, an area of research that is consistent with trans-NIH initiative to identify and generate novel substance use treatments for adolescents (see PA-15-036 and PA-15-256).
项目总结/文摘

项目成果

期刊论文数量(0)
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会议论文数量(0)
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Lindsay Squeglia其他文献

Lindsay Squeglia的其他文献

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{{ truncateString('Lindsay Squeglia', 18)}}的其他基金

Neurobehavioral effects of cannabidiol in youth alcohol use disorder
大麻二酚对青少年酒精使用障碍的神经行为影响
  • 批准号:
    10629333
  • 财政年份:
    2022
  • 资助金额:
    $ 20.08万
  • 项目类别:
Neurobehavioral effects of cannabidiol in youth alcohol use disorder
大麻二酚对青少年酒精使用障碍的神经行为影响
  • 批准号:
    10431507
  • 财政年份:
    2022
  • 资助金额:
    $ 20.08万
  • 项目类别:
MUSC High School Teen Science Ambassador Program
MUSC 高中青少年科学大使计划
  • 批准号:
    10672988
  • 财政年份:
    2021
  • 资助金额:
    $ 20.08万
  • 项目类别:
MUSC High School Teen Science Ambassador Program
MUSC 高中青少年科学大使计划
  • 批准号:
    10216483
  • 财政年份:
    2021
  • 资助金额:
    $ 20.08万
  • 项目类别:
MUSC High School Teen Science Ambassador Program
MUSC 高中青少年科学大使计划
  • 批准号:
    10482332
  • 财政年份:
    2021
  • 资助金额:
    $ 20.08万
  • 项目类别:
Neuroscience-informed Treatment Development for Adolescent Alcohol Use Disorders
青少年酒精使用障碍的神经科学治疗方法开发
  • 批准号:
    9354398
  • 财政年份:
    2016
  • 资助金额:
    $ 20.08万
  • 项目类别:
Brain Structural and Functional Predictors of Adolescent Alcohol Use
青少年饮酒的脑结构和功能预测因子
  • 批准号:
    8718764
  • 财政年份:
    2013
  • 资助金额:
    $ 20.08万
  • 项目类别:
Brain Structural and Functional Predictors of Adolescent Alcohol Use
青少年饮酒的脑结构和功能预测因素
  • 批准号:
    8525697
  • 财政年份:
    2013
  • 资助金额:
    $ 20.08万
  • 项目类别:
Impact of Alcohol Use on Adolescent fMRI BOLD Response: A Longitudinal Study
饮酒对青少年 fMRI BOLD 反应的影响:一项纵向研究
  • 批准号:
    7809050
  • 财政年份:
    2009
  • 资助金额:
    $ 20.08万
  • 项目类别:

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高剂量对乙酰氨基酚与 n-乙酰半胱氨酸救援作为具有抗癌干细胞特性的新型 STAT3 抑制剂
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