Impact of Alcohol Use on Adolescent fMRI BOLD Response: A Longitudinal Study

饮酒对青少年 fMRI BOLD 反应的影响：一项纵向研究

• 批准号: 7809050
• 负责人: Lindsay Squeglia
• 金额: $ 3.07万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7809050
• 关键词: 16 year old; Adolescence; Adolescent; Alcohol consumption; Alcoholic beverage heavy drinker; Alcoholism; Alcohols; Attention; Bilateral; Brain; Cognition; Complex; Cross-Sectional Studies; Data; Deltastab; Digit structure; Functional Magnetic Resonance Imaging; Future; Goals; Heavy Drinking; Image; Individual; Inferior; Investigation; Link; Longitudinal Studies; Measures; Medial; Neurocognitive; Occupational; Parietal; Pattern; Performance; Prevention; Recording of previous events; Regression Analysis; Research; Risk; Services; Short-Term Memory; Specific qualifier value; Testing; Time; Visual; Work; Youth; adolescent alcohol; base; binge drinking; blood oxygen level dependent; cognitive function; design; drinking; executive function; follow-up; heavy drinking during adolescence; information processing; interest; memory process; neurobehavioral; neuroimaging; neuropsychological; programs; psychoeducational intervention; public health relevance; relating to nervous system; response; tool; underage drinking; vigilance; visual memory

DESCRIPTION (provided by applicant): Rationale: Substantial numbers of adolescents engage in moderate to heavy levels of alcohol consumption. Specifically, 44% of 12th graders have used alcohol in past month, and 26% have engaged in a binge drinking episode in the past two weeks (Johnston et al., 2008). Identifying the influence of adolescent alcohol use on brain functioning is important, as decrements incurred during ongoing neuromaturation could have lasting effects on cognitive functioning and future educational and occupational options. Visual working memory (VWM) is an essential component of information processing and executive functioning, and is therefore a useful probe for examining neural abnormalities associated with heavy adolescent drinking. Design: The aims of this investigation are: (1) to prospectively examine brain response to a VWM task in adolescents who transition into heavy drinking (n = 22) versus youth who remain non-users (n = 22) using blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI), and (2) examine if these neural abnormalities are associated with neuropsychological functioning. The proposed study uses data collected as part ofthe Sponsor's longitudinal study (fMRI and Cognition in Youth at Risk for Alcoholism, ROI AAI3419, 6/10/07-3/31/12), using data from 12-16 year-olds imaged prior to the onset of drinking as well as follow-up data collected after half transitioned to heavy drinking. Analyses employ Analysis of Functional Neuroimaging (AFNI) tools and conduct a group x time ANOVA on a priori specified regions of interest (right postcentral/inferior parietal, right middle frontal, bilateral medial frontal, and middle occipital regions) to see if youth who initiate heavy drinking show a change in activation pattern, as compared to youth who remain non-drinkers. Regions that show divergent activation in initiators of heavy drinking will be followed by examining correspondence to performance on neuropsychological measures of VWM and attention among the heavy drinkers (n = 22) in regression analyses. PUBLIC HEALTH RELEVANCE: This investigation will help clarify the effects of alcohol use on brain functioning during adolescence, and aid in understanding whether deficits in VWM result from alcohol involvement. Deficits in VWM could interfere with tasks requiring higher-order executive functioning. The long-term goals of this line of work are to (1) disseminate any findings through adolescent drinking prevention materials and public service campaigns, and (2) inform intervention and psychoeducational programs on how to optimally intervene with youth engaging in heavy drinking, considering brain response and neurocognitive patterns linked to adolescent alcohol use.

描述（由申请人提供）：理由：大量青少年进行中等至大量的饮酒量。具体来说，过去一个月中有44％的12年级学生在使用酒精，在过去的两周中有26％的饮酒发作（Johnston等，2008）。确定青少年饮酒对脑功能的影响很重要，因为在进行的神经饱和过程中产生的减少可能对认知功能以及未来的教育和职业选择产生持久影响。视觉工作记忆（VWM）是信息处理和执行功能的重要组成部分，因此是检查与大量青少年饮酒相关的神经异常的有用探针。设计：这项调查的目的是：（1）前瞻性地检查大脑对VWM任务的反应，他们在过渡为大量饮酒的青少年（n = 22）与仍然是非用户（n = 22）的青少年（n = 22）使用血液氧气依赖性（BOLD）功能磁共振成像（FMRI），以及（2）检查这些神经性相关的功能相关。拟议的研究使用收集的数据作为赞助商的纵向研究（fMRI和有酒精中毒风险的年轻人的认知，ROI AAI3419，6/10/07-3/31/12），使用12-16岁年龄段的数据在饮酒开始之前成像的12-16岁年龄段的数据，以及一半过渡后的随访数据。分析采用功能性神经影像学（AFNI）工具的分析，并在先验的特定感兴趣的区域（正确的中心/下层，右中间，右侧，双边额叶和中枕部区域）上进行X组时间方差分析，以查看年轻人是否会在活跃模式中表现出重大饮酒的年轻人，以及与年轻人相比，与年轻人相比，这是否显示出重量的变化。在回归分析中，表明大量饮酒发起人的激活的区域将检查对vWM神经心理学测量的表现和注意力（n = 22）的对应。 公共卫生相关性：这项调查将有助于阐明饮酒对青春期脑功能的影响，并有助于了解VWM缺陷是否是由于酒精参与而导致的。 VWM中的缺陷可能会干扰需要高阶执行功能的任务。这项工作的长期目标是（1）通过青少年饮酒材料和公共服务活动来传播任何发现，以及（2）为如何最佳干预与青少年进行大脑反应和与青少年酒精饮酒相关的神经认知模式，为如何最佳地干预青少年进行干预和心理教育计划。