Impact of Alcohol Use on Adolescent fMRI BOLD Response: A Longitudinal Study
饮酒对青少年 fMRI BOLD 反应的影响:一项纵向研究
基本信息
- 批准号:7809050
- 负责人:
- 金额:$ 3.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-30 至 2011-09-29
- 项目状态:已结题
- 来源:
- 关键词:16 year oldAdolescenceAdolescentAlcohol consumptionAlcoholic beverage heavy drinkerAlcoholismAlcoholsAttentionBilateralBrainCognitionComplexCross-Sectional StudiesDataDeltastabDigit structureFunctional Magnetic Resonance ImagingFutureGoalsHeavy DrinkingImageIndividualInferiorInvestigationLinkLongitudinal StudiesMeasuresMedialNeurocognitiveOccupationalParietalPatternPerformancePreventionRecording of previous eventsRegression AnalysisResearchRiskServicesShort-Term MemorySpecific qualifier valueTestingTimeVisualWorkYouthadolescent alcoholbasebinge drinkingblood oxygen level dependentcognitive functiondesigndrinkingexecutive functionfollow-upheavy drinking during adolescenceinformation processinginterestmemory processneurobehavioralneuroimagingneuropsychologicalprogramspsychoeducational interventionpublic health relevancerelating to nervous systemresponsetoolunderage drinkingvigilancevisual memory
项目摘要
DESCRIPTION (provided by applicant): Rationale: Substantial numbers of adolescents engage in moderate to heavy levels of alcohol consumption. Specifically, 44% of 12th graders have used alcohol in past month, and 26% have engaged in a binge drinking episode in the past two weeks (Johnston et al., 2008). Identifying the influence of adolescent alcohol use on brain functioning is important, as decrements incurred during ongoing neuromaturation could have lasting effects on cognitive functioning and future educational and occupational options. Visual working memory (VWM) is an essential component of information processing and executive functioning, and is therefore a useful probe for examining neural abnormalities associated with heavy adolescent drinking. Design: The aims of this investigation are: (1) to prospectively examine brain response to a VWM task in adolescents who transition into heavy drinking (n = 22) versus youth who remain non-users (n = 22) using blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI), and (2) examine if these neural abnormalities are associated with neuropsychological functioning. The proposed study uses data collected as part ofthe Sponsor's longitudinal study (fMRI and Cognition in Youth at Risk for Alcoholism, ROI AAI3419, 6/10/07-3/31/12), using data from 12-16 year-olds imaged prior to the onset of drinking as well as follow-up data collected after half transitioned to heavy drinking. Analyses employ Analysis of Functional Neuroimaging (AFNI) tools and conduct a group x time ANOVA on a priori specified regions of interest (right postcentral/inferior parietal, right middle frontal, bilateral medial frontal, and middle occipital regions) to see if youth who initiate heavy drinking show a change in activation pattern, as compared to youth who remain non-drinkers. Regions that show divergent activation in initiators of heavy drinking will be followed by examining correspondence to performance on neuropsychological measures of VWM and attention among the heavy drinkers (n = 22) in regression analyses.
PUBLIC HEALTH RELEVANCE: This investigation will help clarify the effects of alcohol use on brain functioning during adolescence, and aid in understanding whether deficits in VWM result from alcohol involvement. Deficits in VWM could interfere with tasks requiring higher-order executive functioning. The long-term goals of this line of work are to (1) disseminate any findings through adolescent drinking prevention materials and public service campaigns, and (2) inform intervention and psychoeducational programs on how to optimally intervene with youth engaging in heavy drinking, considering brain response and neurocognitive patterns linked to adolescent alcohol use.
描述(由申请人提供):理由:相当数量的青少年从事中度至重度酒精消费。具体来说,44%的12年级学生在过去的一个月里使用过酒精,26%的学生在过去的两周内酗酒(Johnston et al., 2008)。确定青少年饮酒对大脑功能的影响是很重要的,因为在持续的神经成熟过程中发生的衰退可能对认知功能和未来的教育和职业选择产生持久的影响。视觉工作记忆(VWM)是信息处理和执行功能的重要组成部分,因此是检查与青少年大量饮酒相关的神经异常的有用探针。设计:本研究的目的是:(1)使用血氧水平依赖(BOLD)功能磁共振成像(fMRI)前瞻性地检查过渡到重度饮酒的青少年(n = 22)与不饮酒的青少年(n = 22)对VWM任务的大脑反应,(2)检查这些神经异常是否与神经心理功能有关。拟议的研究使用作为赞助商纵向研究的一部分收集的数据(酒精中毒风险青年的fMRI和认知,ROI aai3419,6/10/07 -3/31/12),使用12-16岁儿童在饮酒前的成像数据以及在一半过渡到重度饮酒后收集的随访数据。分析采用功能神经影像学分析(AFNI)工具,并对先验的特定区域(右侧中央后/下顶叶区、右侧额叶中部区、双侧额叶内侧区和枕叶中部区)进行x组时间方差分析,以观察开始大量饮酒的年轻人与不饮酒的年轻人相比,是否表现出激活模式的变化。在回归分析中,酗酒者在VWM和注意力的神经心理学测量上的表现与显示出不同激活的区域之间的对应关系(n = 22)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Lindsay Squeglia其他文献
Lindsay Squeglia的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Lindsay Squeglia', 18)}}的其他基金
Neurobehavioral effects of cannabidiol in youth alcohol use disorder
大麻二酚对青少年酒精使用障碍的神经行为影响
- 批准号:
10629333 - 财政年份:2022
- 资助金额:
$ 3.07万 - 项目类别:
Neurobehavioral effects of cannabidiol in youth alcohol use disorder
大麻二酚对青少年酒精使用障碍的神经行为影响
- 批准号:
10431507 - 财政年份:2022
- 资助金额:
$ 3.07万 - 项目类别:
MUSC High School Teen Science Ambassador Program
MUSC 高中青少年科学大使计划
- 批准号:
10672988 - 财政年份:2021
- 资助金额:
$ 3.07万 - 项目类别:
MUSC High School Teen Science Ambassador Program
MUSC 高中青少年科学大使计划
- 批准号:
10216483 - 财政年份:2021
- 资助金额:
$ 3.07万 - 项目类别:
MUSC High School Teen Science Ambassador Program
MUSC 高中青少年科学大使计划
- 批准号:
10482332 - 财政年份:2021
- 资助金额:
$ 3.07万 - 项目类别:
Neuroscience-informed Treatment Development for Adolescent Alcohol Use Disorders
青少年酒精使用障碍的神经科学治疗方法开发
- 批准号:
9764215 - 财政年份:2016
- 资助金额:
$ 3.07万 - 项目类别:
Neuroscience-informed Treatment Development for Adolescent Alcohol Use Disorders
青少年酒精使用障碍的神经科学治疗方法开发
- 批准号:
9354398 - 财政年份:2016
- 资助金额:
$ 3.07万 - 项目类别:
Brain Structural and Functional Predictors of Adolescent Alcohol Use
青少年饮酒的脑结构和功能预测因子
- 批准号:
8718764 - 财政年份:2013
- 资助金额:
$ 3.07万 - 项目类别:
Brain Structural and Functional Predictors of Adolescent Alcohol Use
青少年饮酒的脑结构和功能预测因素
- 批准号:
8525697 - 财政年份:2013
- 资助金额:
$ 3.07万 - 项目类别:
相似海外基金
Identification of Prospective Predictors of Alcohol Initiation During Early Adolescence
青春期早期饮酒的前瞻性预测因素的鉴定
- 批准号:
10823917 - 财政年份:2024
- 资助金额:
$ 3.07万 - 项目类别:
Socio-Emotional Characteristics in Early Childhood and Offending Behaviour in Adolescence
幼儿期的社会情感特征和青春期的犯罪行为
- 批准号:
ES/Z502601/1 - 财政年份:2024
- 资助金额:
$ 3.07万 - 项目类别:
Fellowship
Reasoning about Spatial Relations and Distributions: Supporting STEM Learning in Early Adolescence
空间关系和分布的推理:支持青春期早期的 STEM 学习
- 批准号:
2300937 - 财政年份:2023
- 资助金额:
$ 3.07万 - 项目类别:
Continuing Grant
Cognitive and non-cognitive abilities and career development during adolescence and adult development: from the perspective of genetic and environmental structure
青春期和成人发展期间的认知和非认知能力与职业发展:从遗传和环境结构的角度
- 批准号:
23K02900 - 财政年份:2023
- 资助金额:
$ 3.07万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Does social motivation in adolescence differentially predict the impact of childhood threat exposure on developing suicidal thoughts and behaviors
青春期的社会动机是否可以差异预测童年威胁暴露对自杀想法和行为的影响
- 批准号:
10785373 - 财政年份:2023
- 资助金额:
$ 3.07万 - 项目类别:
Mapping the Neurobiological Risks and Consequences of Alcohol Use in Adolescence and Across the Lifespan
绘制青春期和整个生命周期饮酒的神经生物学风险和后果
- 批准号:
10733406 - 财政年份:2023
- 资助金额:
$ 3.07万 - 项目类别:
Thalamo-prefrontal circuit maturation during adolescence
丘脑-前额叶回路在青春期成熟
- 批准号:
10585031 - 财政年份:2023
- 资助金额:
$ 3.07万 - 项目类别:
The Role of Sleep in the Relationships Among Adverse Childhood Experiences, Mental Health Symptoms, and Persistent/Recurrent Pain during Adolescence
睡眠在不良童年经历、心理健康症状和青春期持续/复发性疼痛之间关系中的作用
- 批准号:
10676403 - 财政年份:2023
- 资助金额:
$ 3.07万 - 项目类别:
Interdisciplinary Perspectives on the Politics of Adolescence and Democracy
青少年政治与民主的跨学科视角
- 批准号:
EP/X026825/1 - 财政年份:2023
- 资助金额:
$ 3.07万 - 项目类别:
Research Grant
Harnessing digital data to study 21st-century adolescence
利用数字数据研究 21 世纪青春期
- 批准号:
MR/X028801/1 - 财政年份:2023
- 资助金额:
$ 3.07万 - 项目类别:
Research Grant