Connectomes Related to Anxiety and Depression in Adolescents

与青少年焦虑和抑郁相关的连接组

• 批准号: 9763085
• 负责人: JOHN GABRIELI
• 金额: $ 36.15万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-11-28 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9763085
• 关键词: 15 year old; Accidents; Acute; Adherence; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Affect; Age; Amygdaloid structure; Anxiety; Anxiety Disorders; Area; Atlases; Base of the Brain; Behavioral; Boston; Brain; Categories; Cause of Death; Clinic; Clinical; Collaborations; Communities; Corpus striatum structure; Data; Data Collection; Data Set; Detection; Development; Diagnosis; Diagnostic; Diffusion Magnetic Resonance Imaging; Disease; Emotions; Expectancy; Face; Fright; Functional Magnetic Resonance Imaging; Funding Opportunities; Gambling; General Hospitals; Hospitals; Human; Image; Institutes; Literature; Longevity; Magnetic Resonance Imaging; Massachusetts; Measures; Medial; Mental Depression; Mental disorders; Methods; Midbrain structure; Mood Disorders; Morphologic artifacts; National Institute of Mental Health; Negative Valence; Participant; Patient Self-Report; Patients; Physiological; Plant Roots; Positioning Attribute; Positive Valence; Prefrontal Cortex; Protocols documentation; Psychiatric Diagnosis; Public Health; Research; Research Domain Criteria; Research Personnel; Resources; Rest; Rewards; Sampling; Source; Structure; Substance abuse problem; Suicide; System; Technology; United States National Institutes of Health; Universities; Variant; Ventral Striatum; Ventral Tegmental Area; Washington; attentional bias; bioimaging; conditioned fear; connectome; experience; fly; human disease; interest; neural network; neuroimaging; prisma; reconstruction; recruit; response; reward expectancy; tool; white matter

This proposal is submitted in response to NIH Funding Opportunity Connectome Related to Human Disease (U01) and in response to NIMH's priority/disease area of interest mood and anxiety disorders. This is a collaborative effort among researchers at the Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), McLean Hospital, Boston University, and the Human Connectome Project (HCP) at Washington University in St. Louis. We believe that the combination of (1) state-of-the art MRI technology and methods at the MGH Martinos Center for Biomedical Imaging, (2) an active collaboration with the HCP to validate neuroimaging harmonization, (3) a Boston-wide consortium of experienced and expert clinical researchers, and (4) a transdiagnostic focus across the anxiety and depression spectrum can deliver a high- quality dataset that meets the specification of the Funding Opportunity. We propose to focus on an area of great clinical need and public health implication: better understanding of psychiatric disorders in adolescence. We target anxiety and depression as diseases that affect many adolescents across multiple traditional psychiatric diagnoses, that are strongly associated with two leading causes of death in adolescents and young adults (suicide and substance-abuse related accidents), and that are understood to frequently have developmental roots leading to lifelong psychiatric disorders. Our research approach is guided by two principles (1) careful adherence to HCP protocols so as to develop large-scale, integrated, and growing data sets available to the scientific community, and (2) a research approach aligned with two constructs from the NIMH Research Domain Criteria Project (RDoC), specifically: (a) the “Acute Threat/Fear” construct, which is associated with atypical structure and function in specific neural networks, especially amygdala, orbitofrontal cortex (OFC), and ventral medial prefrontal cortex (vmPFC); and (b) the “Reward Prediction Error” construct, which is associated with OFC, ventral striatum, and the midbrain ventral tegmental area. Across four years we aim to (1) operationalize MRI data collection and behavioral characterization that is harmonized and validated with the Human Connectome Project (HCP); (2) recruit and characterize clinically and behaviorally, 225 adolescents ages 14-15 with and without anxiety and/or depression (180 patients, 45 controls); and (3) perform and analyze HCP imaging with participants. We hypothesize that greater activation in the amygdala-OFC circuit will correlate with more severe scores on measures of fear, and that lesser activation of the striatal-OFC circuit will correlate with more severe scores on measures of reward-error expectancy. We will also (a) examine whether neuroimaging analyses are enhanced with artifact-detection tools and physiological aliasing correction that are publicly available and could be integrated with the HCP, and (b) create an age-specific human tract atlas and tools for automated reconstruction of white-matter tracts involved in the above circuits, which will also be made publicly available.

本提案是对美国国立卫生研究院资助机会与人类疾病相关的Connectome的回应 (U01)，并针对NIMH的优先/感兴趣疾病领域、情绪和焦虑症。这是一个 麻省理工学院马萨诸塞州综合医院(MGH)的研究人员之间的合作努力 麻省理工学院(MIT)、波士顿大学麦克莱恩医院和人类连接组项目(HCP) 华盛顿大学圣路易斯分校。我们相信(1)最先进的核磁共振技术和 方法在MGH Martinos生物医学成像中心，(2)与HCP积极合作，以 验证神经成像协调，(3)波士顿范围内经验丰富的临床专家联盟 研究人员，以及(4)跨焦虑和抑郁谱系的跨诊断焦点可以提供高- 符合资助机会规格的高质量数据集。我们建议将重点放在以下领域 巨大的临床需求和公共卫生含义：更好地理解青春期精神障碍。 我们将焦虑和抑郁作为影响许多青少年的疾病，这些疾病跨越多个传统 精神病学诊断，与青少年和青少年死亡的两个主要原因密切相关 成年人(自杀和药物滥用相关事故)，据了解经常有 导致终生精神障碍的发育根源。我们的研究方法以两个方面为指导 原则(1)认真遵守HCP协议，以开发大规模、集成和不断增长的数据 可供科学界使用的集合，以及(2)与来自 NIMH研究领域标准项目(RDoC)，具体地说：(A)“急性威胁/恐惧”概念，即 与特定神经网络中的非典型结构和功能有关，特别是杏仁核、眶前叶 大脑皮层(OFC)和腹侧前额叶皮质(VmPFC)；以及(B)“奖励预测误差”结构， 它与OFC、腹侧纹状体和中脑腹侧被盖区有关。四年来，我们 目的：(1)可操作的MRI数据收集和行为特征的协调和验证 人类连接组计划(HCP)；(2)招募和描述临床和行为特征，225 有或没有焦虑和/或抑郁的14-15岁青少年(180名患者，45名对照)；以及(3) 并与参与者一起分析HCP成像。我们假设杏仁核-OFC中更大的激活 环路将与恐惧测量中更严重的分数相关，纹状体-OFC的激活程度更低 赛道将与更严重的奖励错误预期测量分数相关。我们还将(A) 检查是否使用伪影检测工具和生理性混叠增强了神经成像分析 可公开获得并可与母婴健康方案整合的矫正，以及(B)创建特定于年龄的 上述回路中涉及的白质束自动重建的人体束图和工具， 它也将公开可用。

项目成果

Convergence, preliminary findings and future directions across the four human connectome projects investigating mood and anxiety disorders.

• DOI: 10.1016/j.neuroimage.2021.118694
• 发表时间: 2021-12-15
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Tozzi L;Anene ET;Gotlib IH;Wintermark M;Kerr AB;Wu H;Seok D;Narr KL;Sheline YI;Whitfield-Gabrieli S;Williams LM
• 通讯作者: Williams LM

Treatments for internet addiction, sex addiction and compulsive buying: A meta-analysis.

• DOI: 10.1556/2006.2020.00005
• 发表时间: 2020-04-01
• 期刊: Journal of behavioral addictions
• 影响因子: 7.8
• 作者: Goslar M;Leibetseder M;Muench HM;Hofmann SG;Laireiter AR
• 通讯作者: Laireiter AR

Formalizing psychological interventions through network control theory.

• DOI: 10.1038/s41598-023-40648-x
• 发表时间: 2023-08-24
• 期刊: Scientific reports
• 影响因子: 4.6

Improving Suicide Prevention Through Evidence-Based Strategies: A Systematic Review.

• DOI: 10.1176/appi.ajp.2020.20060864
• 发表时间: 2021-07
• 期刊: AMERICAN JOURNAL OF PSYCHIATRY
• 影响因子: 17.7
• 作者: Mann, J. John;Michel, Christina A.;Auerbach, Randy P.
• 通讯作者: Auerbach, Randy P.

Automated detection of axonal damage along white matter tracts in acute severe traumatic brain injury.

• DOI: 10.1016/j.nicl.2022.103294
• 发表时间: 2023
• 期刊: NEUROIMAGE-CLINICAL
• 影响因子: 4.2
• 作者: Maffei, Chiara;Gilmore, Natalie;Snider, Samuel B.;Foulkes, Andrea S.;Bodien, Yelena G.;Yendiki, Anastasia;Edlow, Brian L.
• 通讯作者: Edlow, Brian L.