Antimicrobial and Biocompatible Endotracheal Tubes
Antimicrobial and Biocompatible Endotracheal Tubes
批准号:
9763984
负责人:
XUEJUN WEN
金额:
$70.89万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-08-15 至 2021-04-30
关键词:
Animal ModelAntibioticsCellsCenters for Disease Control and Prevention (U.S.)Cessation of lifeChargeChemistryClinical ResearchCulture MediaDermalDevicesDiagnosisEffectivenessElderlyEnterobacteriaceaeEscherichia coliEsophagusEvaluationEventFibroblastsHeavy MetalsHourHumanIn VitroIncidenceInfectionIntratracheal IntubationIntubationKlebsiella pneumonia bacteriumLeadLegal patentMechanical ventilationModelingModificationMucous body substanceNosocomial pneumoniaOryctolagus cuniculusOutcomePatientsPhasePolyethylene GlycolsProcessPseudomonas aeruginosaReportingResearchSiliconesSilverStaphylococcus aureusTechnologyTestingTracheaTraumaTubeUnited StatesVentilatorViscosityWorkantimicrobialbiomaterial compatibilitydesignendotrachealfightingflasksfungushigh riskin vitro testingin vivoin vivo evaluationinnovationmultidisciplinarynanoneonatenew technologynovel strategiesoff-patentpathogenpatient safetypreventscale upventilator-associated pneumonia
中文摘要
呼吸机相关性肺炎(VAP)发生在以下48-72小时(或更长时间)
气管内插管,占所有医院获得性
肺炎CDC报告和许多临床研究指出,
预防呼吸机相关感染,而不是打一场经常失败的战斗
防止后天感染为了应对这一未满足的需求,WynnVision LLC,“WV”将
利用抗微生物但细胞相容性(ABC)纳米
在制造的插管产品上添加涂层,以开发一种新技术,
消除或大大减少VAP/VAE。西弗吉尼亚州的做法,受到最近的保护,
专利申请,将涉及多学科活动和第三方测试,
便于接近FDA获得批准。
英文摘要
Ventilator-associated pneumonia (VAP) occurs 48–72 hours (or more) following
endotracheal intubation and accounts for half of all cases of hospital-acquired
pneumonia. CDC reports and many clinical studies point to a critical need for
preventing ventilator associated infections rather than fighting an often losing battle
against acquired infection. Responding to this unmet need, WynnVision LLC, “WV” will
leverage strong preliminary results for antimicrobial-but-cytocompatible (ABC) nano-
overcoats on as-manufactured intubation products to develop a new technology for
eliminating or greatly reducing VAP/VAE. The WV approach, protected by a recent
patent application, will involve multidisciplinary activities and third party testing to
facilitate approaching FDA for approval.
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海外基金