Engaging Working Memory and Distress Tolerance to Aid Smoking Cessation
Engaging Working Memory and Distress Tolerance to Aid Smoking Cessation
批准号:
9767106
负责人:
Michael W. Otto
金额:
$20.98万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-01 至 2021-08-31
关键词:
AmericanAttentionBackBehavior ControlBiological AssayClinicalCognitiveDigit structureEmotionalEmotionsExposure toFaceFailureGoalsHealth behaviorImpairmentIndividualInformal Social ControlInterventionInvestigational TherapiesKnowledgeLaboratoriesLinkLow incomeMeasuresMindfulness TrainingModelingModificationNicotineNicotine WithdrawalOutcomePersonsPopulation CharacteristicsProcessProtocols documentationPsychological reinforcementPublishingRegulationRelapseResearchRiskRisk FactorsScheduleSelf-control as a personality traitSeveritiesShort-Term MemorySmokeSmokerSmokingSocioeconomic StatusStressTherapeuticTimeWithdrawalWithdrawal SymptomWorkanxiety sensitivitybasebehavior changecigarette smokeclinically relevantcravingdeprivationdistress toleranceemotional behaviorevidence baseimprovedinnovationlow socioeconomic statusmindfulnessmindfulness interventionnegative affectnicotine usenovelrelapse riskresiliencesmoking cessationsmoking prevalencestress reactivitystress resiliencestress symptomstressortherapy development
中文摘要
项目总结/文摘
英文摘要
PROJECT SUMMARY/ABSTRACT
Recent estimates indicate that both low income and educational attainment are among the strongest
predictors of both smoking prevalence and continued smoking. Treatment development is limited by
inadequate knowledge of the specific lapse/relapse-relevant vulnerabilities characteristic of these populations
(i.e, the processes that underpin lapse/relapse). Recently, we published a comprehensive model of the way in
which these cognitive and emotional vulnerabilities--lower WMC and elevated AS--represent separate liabilities
for negative health behaviors and self-control lapses, particularly under conditions of stress. The interactive
models we propose suggest that interventions targeting only some of these vulnerabilities will leave smokers at
risk for cessation failure. Accordingly, interventions that can engage these multiple vulnerabilities have the
potential to greatly benefit at-risk subsamples of smokers, such as low SES smokers. Accordingly, this project
is devoted to using an experimental therapeutics approach to show: (1) that a standard mindfulness
intervention, and a mindfulness intervention modified in accordance with crucial preliminary work
(Mindfulness+IE), have the ability to differentially engage these triple risk mechanistic targets, and (2) that the
degree to which these putative triple risk targets are engaged produces a desired change in a health behavior,
using a laboratory model of smoking risk burden and lapse potential. An innovative approach for understanding
risk for relapse in smokers undergoing a quit attempt is to examine candidate mechanistic targets assessed
not only during nicotine use, but during the conditions smokers will face upon a cessation attempt – during
nicotine deprivation windows. In particular, we intend to show the incremental value of assessments during
deprivation windows, in part due to the way in which triple vulnerabilities are modified by and interact with the
heightened stress and withdrawal symptoms inherent to nicotine deprivation states in smokers. We also intent
to show that a novel mindfulness intervention (Mindfulness+IE) can rescue limitations of standard mindfulness
interventions, by extending therapeutic gains to the modification of mechanistic targets assessed in high-stress
contexts. The overall goal is to validate mechanistic targets and associated interventions for the purpose of
expanding treatment options for particularly at-risk smokers.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
2/2-CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy
-
批准号:10614510
-
项目类别:
-
资助金额:$56.54万
-
财政年份:2022
-
负责人:Michael W. Otto
-
依托单位:
2/2-CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy
-
批准号:10363061
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项目类别:
-
资助金额:$59.63万
-
财政年份:2022
-
负责人:Michael W. Otto
-
依托单位:
Engaging Working Memory and Distress Tolerance to Aid Smoking Cessation
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批准号:9928212
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项目类别:
-
资助金额:$0.82万
-
财政年份:2018
-
负责人:Michael W. Otto
-
依托单位:
Improving Therapeutic Learning in Depression: Proof of Concept
-
批准号:8621206
-
项目类别:
-
资助金额:$24.66万
-
财政年份:2014
-
负责人:Michael W. Otto
-
依托单位:
Enhancing Panic and Smoking Reduction Treatment with D-Cycloserine
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批准号:8731846
-
项目类别:
-
资助金额:$20.26万
-
财政年份:2013
-
负责人:Michael W. Otto
-
依托单位:
Enhancing Panic and Smoking Reduction Treatment with D-Cycloserine
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批准号:8790514
-
项目类别:
-
资助金额:$21.98万
-
财政年份:2013
-
负责人:Michael W. Otto
-
依托单位:
1/3-Exposure D-Cycloserine Enhancement and Genetic Modulators in Panic Disorder
-
批准号:7795774
-
项目类别:
-
资助金额:$25.59万
-
财政年份:2008
-
负责人:Michael W. Otto
-
依托单位:
Excellence In Training: The Center for Anxiety and Related Disorders at BU
-
批准号:7558423
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项目类别:
-
资助金额:$3.24万
-
财政年份:2008
-
负责人:Michael W. Otto
-
依托单位:
Excellence In Training: The Center for Anxiety and Related Disorders at BU
-
批准号:8268550
-
项目类别:
-
资助金额:$3.09万
-
财政年份:2008
-
负责人:Michael W. Otto
-
依托单位:
Excellence In Training: The Center for Anxiety and Related Disorders at BU
-
批准号:7693703
-
项目类别:
-
资助金额:$3.2万
-
财政年份:2008
-
负责人:Michael W. Otto
-
依托单位:
Excellence In Training: The Center for Anxiety and Related Disorders at BU
-
批准号:8065476
-
项目类别:
-
资助金额:$3.14万
-
财政年份:2008
-
负责人:Michael W. Otto
-
依托单位:
1/3-Exposure D-Cycloserine Enhancement and Genetic Modulators in Panic Disorder
-
批准号:8265909
-
项目类别:
-
资助金额:$21.72万
-
财政年份:2008
-
负责人:Michael W. Otto
-
依托单位:
Excellence In Training: The Center for Anxiety and Related Disorders at BU
-
批准号:7805473
-
项目类别:
-
资助金额:$3.13万
-
财政年份:2008
-
负责人:Michael W. Otto
-
依托单位:
1/3-Exposure D-Cycloserine Enhancement and Genetic Modulators in Panic Disorder
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批准号:8051528
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项目类别:
-
资助金额:$25.34万
-
财政年份:2008
-
负责人:Michael W. Otto
-
依托单位:
1/3-Exposure D-Cycloserine Enhancement and Genetic Modulators in Panic Disorder
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批准号:7616446
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项目类别:
-
资助金额:$25.59万
-
财政年份:2008
-
负责人:Michael W. Otto
-
依托单位:
Context Effects in De Novo Fear Conditioning in Humans
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批准号:7007114
-
项目类别:
-
资助金额:$20.66万
-
财政年份:2004
-
负责人:Michael W. Otto
-
依托单位:
Stress, Distress Intolerance, and Drug Dependence
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批准号:6937776
-
项目类别:
-
资助金额:$43.01万
-
财政年份:2004
-
负责人:Michael W. Otto
-
依托单位:
Stress, Distress Intolerance, and Drug Dependence
-
批准号:7244357
-
项目类别:
-
资助金额:$48.26万
-
财政年份:2004
-
负责人:Michael W. Otto
-
依托单位:
Context Effects in De Novo Fear Conditioning in Humans
-
批准号:6838844
-
项目类别:
-
资助金额:$5.54万
-
财政年份:2004
-
负责人:Michael W. Otto
-
依托单位:
Stress, Distress Intolerance, and Drug Dependence
-
批准号:7225726
-
项目类别:
-
资助金额:$4.34万
-
财政年份:2004
-
负责人:Michael W. Otto
-
依托单位:
国内基金
海外基金
多模态超声VisTran-Attention网络评估早期子宫颈癌保留生育功能手术可行性
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批准号:--
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项目类别:青年科学基金项目
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资助金额:30万元
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批准年份:2022
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负责人:郑巧
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依托单位:
Ultrasomics-Attention孪生网络早期精准评估肝内胆管癌免疫治疗的研究
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批准号:--
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项目类别:面上项目
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资助金额:52万元
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批准年份:2022
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负责人:陈立达
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依托单位: