Engaging Working Memory and Distress Tolerance to Aid Smoking Cessation

调动工作记忆和抗压能力来帮助戒烟

• 批准号: 9928212
• 负责人: Michael W. Otto
• 金额: $ 0.82万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9928212
• 关键词: American; Attention; Back; Behavior Control; Biological Assay; Clinical; Cognitive; Digit structure; Emotional; Emotions; Exposure to; Face; Failure; Goals; Health behavior; Impairment; Individual; Informal Social Control; Intervention; Investigational Therapies; Knowledge; Laboratories; Link; Low income; Measures; Mindfulness Training; Modeling; Modification; Nicotine; Nicotine Withdrawal; Outcome; Persons; Population Characteristics; Process; Protocols documentation; Psychological reinforcement; Publishing; Regulation; Relapse; Research; Risk; Risk Factors; Schedule; Self-control as a personality trait; Severities; Short-Term Memory; Smoke; Smoker; Smoking; Socioeconomic Status; Stress; Therapeutic; Time; Withdrawal; Withdrawal Symptom; Work; anxiety sensitivity; base; behavior change; cigarette smoke; clinically relevant; craving; deprivation; distress tolerance; emotional behavior; evidence base; improved; innovation; low socioeconomic status; mindfulness; mindfulness intervention; negative affect; nicotine use; novel; relapse risk; resilience; smoking cessation; smoking prevalence; stress reactivity; stress resilience; stress symptom; stressor; therapy development

PROJECT SUMMARY/ABSTRACT Recent estimates indicate that both low income and educational attainment are among the strongest predictors of both smoking prevalence and continued smoking. Treatment development is limited by inadequate knowledge of the specific lapse/relapse-relevant vulnerabilities characteristic of these populations (i.e, the processes that underpin lapse/relapse). Recently, we published a comprehensive model of the way in which these cognitive and emotional vulnerabilities--lower WMC and elevated AS--represent separate liabilities for negative health behaviors and self-control lapses, particularly under conditions of stress. The interactive models we propose suggest that interventions targeting only some of these vulnerabilities will leave smokers at risk for cessation failure. Accordingly, interventions that can engage these multiple vulnerabilities have the potential to greatly benefit at-risk subsamples of smokers, such as low SES smokers. Accordingly, this project is devoted to using an experimental therapeutics approach to show: (1) that a standard mindfulness intervention, and a mindfulness intervention modified in accordance with crucial preliminary work (Mindfulness+IE), have the ability to differentially engage these triple risk mechanistic targets, and (2) that the degree to which these putative triple risk targets are engaged produces a desired change in a health behavior, using a laboratory model of smoking risk burden and lapse potential. An innovative approach for understanding risk for relapse in smokers undergoing a quit attempt is to examine candidate mechanistic targets assessed not only during nicotine use, but during the conditions smokers will face upon a cessation attempt – during nicotine deprivation windows. In particular, we intend to show the incremental value of assessments during deprivation windows, in part due to the way in which triple vulnerabilities are modified by and interact with the heightened stress and withdrawal symptoms inherent to nicotine deprivation states in smokers. We also intent to show that a novel mindfulness intervention (Mindfulness+IE) can rescue limitations of standard mindfulness interventions, by extending therapeutic gains to the modification of mechanistic targets assessed in high-stress contexts. The overall goal is to validate mechanistic targets and associated interventions for the purpose of expanding treatment options for particularly at-risk smokers.

项目概要/摘要 最近的估计表明，低收入和教育程度都是最强的 吸烟率和持续吸烟的预测因素。治疗方法的发展受到以下因素的限制 对这些人群的具体复发/复发相关脆弱性特征了解不足 （即支持衰退/复发的过程）。最近，我们发布了一种综合模型 这些认知和情感脆弱性（WMC 降低和 AS 升高）代表了单独的责任 针对不良健康行为和自我控制失误，特别是在压力条件下。互动式 我们提出的模型表明，仅针对其中一些脆弱性的干预措施将使吸烟者陷入困境 戒烟失败的风险。因此，能够解决这些多个漏洞的干预措施具有 可能使高危吸烟者子样本（例如低社会经济地位吸烟者）受益匪浅。据此，本项目 致力于使用实验治疗方法来证明：（1）标准的正念 干预，以及根据重要的前期工作修改的正念干预 （正念+IE），有能力区别对待这些三重风险机制目标，并且（2） 这些假定的三重风险目标的参与程度会产生健康行为的预期变化， 使用吸烟风险负担和戒烟潜力的实验室模型。一种创新的理解方法 尝试戒烟的吸烟者复吸的风险是检查评估的候选机械目标 不仅在尼古丁使用过程中，而且在吸烟者尝试戒烟时将面临的情况——在 尼古丁剥夺窗口。特别是，我们打算展示评估期间的增量价值 剥夺窗口，部分原因是三重漏洞被修改并与之交互的方式 吸烟者尼古丁剥夺状态所固有的压力和戒断症状加剧。我们也有意 表明一种新颖的正念干预（正念+IE）可以挽救标准正念的局限性 干预措施，通过将治疗收益扩展到高压力下评估的机械目标的修改 上下文。总体目标是验证机械目标和相关干预措施，以便 扩大针对高危吸烟者的治疗选择。

项目成果

Working memory moderates the predictive influence of distress intolerance on health-related goal attainment.

• DOI: 10.1080/16506073.2020.1819864
• 发表时间: 2021-03
• 期刊: Cognitive behaviour therapy
• 影响因子: 4.7
• 作者: Fitzgerald HE;Gorlin EI;Otto MW
• 通讯作者: Otto MW

The potential role of anxiety sensitivity in the risk for and recovery from heart attacks: Comment on Edmondson et al. (2018).

焦虑敏感性在心脏病发作风险和康复中的潜在作用：对埃德蒙森等人的评论。

• DOI: 10.1037/amp0000479
• 发表时间: 2019
• 期刊: The American psychologist
• 作者: Otto,MichaelW;Fitzgerald,HayleyE;Meyer-Pot,MiriamJ
• 通讯作者: Meyer-Pot,MiriamJ

Community-based smoking cessation treatment for adults with high anxiety sensitivity: a randomized clinical trial.

高焦虑敏感性的成年人基于社区的戒烟治疗：一项随机临床试验。

• DOI: 10.1111/add.15586
• 发表时间: 2021-11
• 期刊: ADDICTION
• 影响因子: 6
• 作者: Smits, Jasper A. J.;Zvolensky, Michael J.;Rosenfield, David;Brown, Richard A.;Otto, Michael W.;Dutcher, Christina D.;Papini, Santiago;Freeman, Slaton Z.;DiVita, Annabelle;Perrone, Alex;Garey, Lorra
• 通讯作者: Garey, Lorra

Do Pain-Related Anxiety and Difficulties With Emotion Regulation Impact Abstinence Expectancies or Motivation to Quit E-Cigarette Use?

• DOI: 10.15288/jsad.2021.82.414
• 发表时间: 2021-05-01
• 期刊: JOURNAL OF STUDIES ON ALCOHOL AND DRUGS
• 影响因子: 3.4
• 作者: Gold，Alexandra K.;Otto，Michael W.;Zvolensky，Michael
• 通讯作者: Zvolensky，Michael

The role of fear of COVID-19 in motivation to quit smoking and reductions in cigarette smoking: a preliminary investigation of at-risk cigarette smokers.

• DOI: 10.1080/16506073.2021.1877340
• 发表时间: 2021-05
• 期刊: Cognitive behaviour therapy
• 影响因子: 4.7
• 作者: Gold AK;Hoyt DL;Milligan M;Hiserodt ML;Samora J;Leyro TM;Zvolensky MJ;Otto MW
• 通讯作者: Otto MW