Tunable microbubbles for antivascular ultrasound
用于抗血管超声的可调微泡
基本信息
- 批准号:9767166
- 负责人:
- 金额:$ 45.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-30 至 2021-07-31
- 项目状态:已结题
- 来源:
- 关键词:AcousticsAnimal ModelAnimalsBiologicalBlood VesselsBlood flowBostonCause of DeathCharacteristicsClinicComputer SimulationCrystallizationDiagnosticEffectivenessEndothelial CellsEnergy-Generating ResourcesExposure toFormulationFutureGoalsGrowthHeatingImage EnhancementImplantKnowledgeLaboratoriesMalignant NeoplasmsMathematicsMeasuresMethodsMicrobubblesMicrofluidic MicrochipsMicrofluidicsMicroscopicModalityModelingModulusMonitorMusOutcomePatientsPhysical therapyPhysiciansPluronicsPreparationProbabilityPropertyQuartzRecombinant ProteinsResearchResearch PersonnelScientistSiteSolid NeoplasmSourceSultanTechniquesTechnologyTemperatureTestingThickTimeTissuesTranslatingTreatment EfficacyUltrasonic TherapyUltrasonic waveUltrasonographyUnited StatesUniversitiesValidationVascular EndotheliumVeterinariansViscosityWood materialcancer therapycontrast enhancedcopolymerdensitydesignefficacy testingexpectationexperimental studyimprovedin vivoin vivo Modelinformation modelinterestirradiationmathematical modelmechanical propertiesneovasculaturenovelnovel strategiespre-clinicalresponsesurfactanttheranosticstreatment responsetumortumor growth
项目摘要
Abstract
Antivascular ultrasound is a novel approach that uses low-amplitude ultrasound and microbubbles to treat cancers. In
the presence of ultrasound irradiation, microbubbles act as microscopic sources that convert acoustic energy into heat
through viscous damping of oscillating bubbles. The localized intravascular heating damages endothelial cells and
disrupt tumor vasculature. Thus microbubbles function as both energy source and ultrasound wave beacons to deliver
acoustic energy locally to the vascular endothelium.
The goals of the research are to model ultrasound-enhanced heating mathematically and to use the model to guide the
synthesis of microbubbles using novel microfluidics techniques. The proposal has three Specific Aims. Specific Aim
1 is to use computational modeling to identify mechanical properties and bubble size distribution that produce
maximum thermal effects. Specific Aim 2 will be to synthesize microbubbles of desired size distribution and shell
properties. Specific Aim 3 will test the efficacy of microbubble preparations in flow phantoms and preclinical animal
model. The experimental results will be compared with theoretical calculations.
Thus both mathematical modeling and the unique method of synthesis will provide an integrated approach for
antivascular therapy. The proposed research develops a completely new ultrasound cancer treatment with significant
advantages over existing techniques. We anticipate that the knowledge gained from the proposed research will lead to
a new form of antivascular therapy for treating cancers.
摘要
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Engineering Theranostic Microbubbles Using Microfluidics for Ultrasound Imaging and Therapy: A Review.
- DOI:10.1016/j.ultrasmedbio.2018.07.026
- 发表时间:2018-12
- 期刊:
- 影响因子:2.9
- 作者:Pulsipher KW;Hammer DA;Lee D;Sehgal CM
- 通讯作者:Sehgal CM
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{{ truncateString('CHANDRA M SEHGAL', 18)}}的其他基金
Antivascular ultrasound therapy of primary liver neoplasia
原发性肝肿瘤的超声抗血管治疗
- 批准号:
9234984 - 财政年份:2017
- 资助金额:
$ 45.36万 - 项目类别:
Antivascular ultrasound therapy of primary liver neoplasia
原发性肝肿瘤的超声抗血管治疗
- 批准号:
10063483 - 财政年份:2017
- 资助金额:
$ 45.36万 - 项目类别:
Tunable microbubbles for antivascular ultrasound
用于抗血管超声的可调微泡
- 批准号:
9157676 - 财政年份:2016
- 资助金额:
$ 45.36万 - 项目类别:
Integrated photoacoustic and ultrasound imaging with the Vevo LAZR
使用 Vevo LAZR 集成光声和超声成像
- 批准号:
8640490 - 财政年份:2014
- 资助金额:
$ 45.36万 - 项目类别:
Quantitative diagnosis of breast cancer with ultrasound
乳腺癌的超声定量诊断
- 批准号:
7581824 - 财政年份:2008
- 资助金额:
$ 45.36万 - 项目类别:
Quantitative diagnosis of breast cancer with ultrasound
乳腺癌的超声定量诊断
- 批准号:
8387042 - 财政年份:2008
- 资助金额:
$ 45.36万 - 项目类别:
Quantitative diagnosis of breast cancer with ultrasound
乳腺癌的超声定量诊断
- 批准号:
8196858 - 财政年份:2008
- 资助金额:
$ 45.36万 - 项目类别:
Quantitative diagnosis of breast cancer with ultrasound
乳腺癌的超声定量诊断
- 批准号:
7742149 - 财政年份:2008
- 资助金额:
$ 45.36万 - 项目类别:
Quantitative diagnosis of breast cancer with ultrasound
乳腺癌的超声定量诊断
- 批准号:
7995228 - 财政年份:2008
- 资助金额:
$ 45.36万 - 项目类别:
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