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Flow-mediated dilation by ultrasound imaging

通过超声成像进行血流介导的扩张

基本信息

批准号：
7140252
负责人：
CHANDRA M SEHGAL
金额：
$ 19.35万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-08-01 至 2008-07-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Endothelial dysfunction, an early marker of atherosclerosis, is a significant cardiovascular risk factor that is implicated for many diseases, including hypertension and diabetes. There is therefore a major effort to develop a noninvasive test for endothelial dysfunction. Flow-mediated dilation of the brachial artery measured by ultrasound imaging offers this possibility, and its use has been demonstrated in various clinical studies. Despite encouraging results, the technique is not recommended for routine clinical use, mainly because of its low sensitivity and large coefficient of variation. This application is designed to overcome these limits . We propose the use of compound imaging to enhance image quality; cross-sectional imaging to improve sensitivity and coefficient of variations, and automated boundary detection for continuous monitoring of vasodilation during ultrasound examination. We tested these concepts is flow phantoms and showed that sensitivity can be improved by as much as 150 times over the conventional method. We also demonstrated the technique could be used to image human subjects. The results were published in a recent article. In this R21 application, we are seeking support for a feasibility study in human subjects. Flow-mediated dilation will be measured in a small number (N = 60) of healthy volunteers . The goal is to demonstrate that ultrasound imaging of brachial artery cross-section using compounding and automated boundary detection have higher sensitivity and reproducibility than the conventional approach using longitudinal imaging. The proposed research will lead to a robust method for measuring FMD, suitable for routine clinical applications. Given the broad involvement of endothelial dysfunction in cardiovascular diseases and that ultrasound imaging is noninvasive and suitable for repeated examinations, the proposed research would have major implication in screening subjects for cardiovascular risks, diagnosing atherosclerosis and monitoring treatment responses.

描述（由申请人提供）：内皮功能障碍是动脉粥样硬化的早期标志物，是一种重要的心血管危险因素，与许多疾病有关，包括高血压和糖尿病。因此，有一个主要的努力，以开发一种非侵入性的测试内皮功能障碍。通过超声成像测量的血流介导的肱动脉扩张提供了这种可能性，并且其用途已在各种临床研究中得到证实。尽管结果令人鼓舞，但不建议将该技术用于常规临床使用，主要是因为其灵敏度低且变异系数大。此应用程序旨在克服这些限制。我们建议使用复合成像，以提高图像质量;横截面成像，以提高灵敏度和变异系数，和自动边界检测连续监测血管舒张在超声检查。我们测试了这些概念是流动幻影，并表明灵敏度可以提高多达150倍，比传统的方法。我们还证明了该技术可用于对人类受试者进行成像。研究结果发表在最近的一篇文章中。在这项R21申请中，我们正在寻求对人类受试者可行性研究的支持。将在少量（N = 60）健康志愿者中测量血流介导的扩张。目的是证明使用复合和自动边界检测的肱动脉横截面超声成像比使用纵向成像的传统方法具有更高的灵敏度和可重复性。拟议的研究将导致一个强大的方法来测量FMD，适用于常规临床应用。鉴于内皮功能障碍在心血管疾病中的广泛参与，以及超声成像是非侵入性的且适合于重复检查，拟议的研究将在筛选受试者的心血管风险、诊断动脉粥样硬化和监测治疗反应方面具有重要意义。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Feed-forward active contour analysis for improved brachial artery reactivity testing.

用于改进肱动脉反应性测试的前馈活动轮廓分析。

DOI：
10.1177/1358863x16634194
发表时间：
2016
期刊：
Vascular medicine (London, England)
影响因子：
0
作者：
Pugliese,DanielN;Sehgal,ChandraM;Sultan,LaithR;Reamer,CourtneyB;Mohler3rd,EmileR
通讯作者：
Mohler3rd,EmileR

On the modeling of mechanotransduction in flow-mediated dilation.

关于血流介导的扩张中的机械传导的建模。