Tunable microbubbles for antivascular ultrasound

摘要 抗血管超声是一种利用低振幅超声和微泡治疗癌症的新方法。在……里面 在超声波照射下，微泡充当将声能转化为热能的微观来源 通过振荡气泡的粘性减振。局部血管内加热损伤内皮细胞， 破坏肿瘤的血管系统。因此，微泡既可以作为能源，也可以作为超声波的信标 声能传到血管内皮细胞的局部。 这项研究的目标是对超声增强加热进行数学建模，并使用该模型来指导 利用新型微流控技术合成微泡。该提案有三个具体目标。特定目标 1是使用计算建模来确定产生的机械性能和气泡尺寸分布 最大的热效应。具体目标2将是合成所需尺寸分布和外壳的微泡 属性。特定目标3将在流动模体和临床前动物中测试微泡制剂的效果 模特。将实验结果与理论计算结果进行了比较。 因此，数学建模和独特的综合方法将提供一种综合的方法 抗血管治疗。这项拟议的研究开发了一种全新的超声波癌症治疗方法，具有显著的 相对于现有技术的优势。我们预计，从拟议的研究中获得的知识将导致 一种治疗癌症的新型抗血管疗法。

Abstract Antivascular ultrasound is a novel approach that uses low-amplitude ultrasound and microbubbles to treat cancers. In the presence of ultrasound irradiation, microbubbles act as microscopic sources that convert acoustic energy into heat through viscous damping of oscillating bubbles. The localized intravascular heating damages endothelial cells and disrupt tumor vasculature. Thus microbubbles function as both energy source and ultrasound wave beacons to deliver acoustic energy locally to the vascular endothelium. The goals of the research are to model ultrasound-enhanced heating mathematically and to use the model to guide the synthesis of microbubbles using novel microfluidics techniques. The proposal has three Specific Aims. Specific Aim 1 is to use computational modeling to identify mechanical properties and bubble size distribution that produce maximum thermal effects. Specific Aim 2 will be to synthesize microbubbles of desired size distribution and shell properties. Specific Aim 3 will test the efficacy of microbubble preparations in flow phantoms and preclinical animal model. The experimental results will be compared with theoretical calculations. Thus both mathematical modeling and the unique method of synthesis will provide an integrated approach for antivascular therapy. The proposed research develops a completely new ultrasound cancer treatment with significant advantages over existing techniques. We anticipate that the knowledge gained from the proposed research will lead to a new form of antivascular therapy for treating cancers.