Integrated photoacoustic and ultrasound imaging with the Vevo LAZR

使用 Vevo LAZR 集成光声和超声成像

• 批准号: 8640490
• 负责人: CHANDRA M SEHGAL
• 金额: $ 49.4万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8640490
• 关键词: Animals; Applications Grants; Area; Biomedical Research; Communities; Diagnostic tests; Education; Elasticity; Frequencies; Funding; Future; Hemoglobin; Home environment; Image; Institution; Measurement; Modality; Oxygen; Penetration; Pennsylvania; Philadelphia; Research; Research Personnel; Research Proposals; Resolution; Resource Sharing; Scanning; Therapeutic Intervention; Time; Translational Research; Ultrasonography; Universities; experience; instrument; novel diagnostics; operation; optical imaging; photoacoustic imaging

DESCRIPTION (provided by applicant): This grant application is a request to purchase a Vevo(R) LAZR scanner for high-resolution, real-time 3D photoacoustic and ultrasound imaging. The scanner will be a part of the Small Animal Imaging Facility (SAIF) at the University of Pennsylvania (UPenn) and will be used as a shared resource by investigators from different departments across campus. The Philadelphia region is home to a large number of premier institutions of basic and translational biomedical research. We will promote the instrument and make it available to other institutions in the Philadelphia area. The Vevo(R) LAZR is a state-of-the-art dual-modality scanner that integrates photoacoustics and high- frequency ultrasound. It combines the sensitivity of optical imaging with the resolution and depth penetration of ultrasound. It is a single platform with multiple applications that include traditional modes like -scan and Doppler imaging along with more advanced applications like elasticity imaging, microvascular imaging, and oxygen saturation and hemoglobin measurements. The versatile instrument will support approximately twenty research proposals. Its operation will be managed by an experienced team with an established track record in animal and imaging research. Funding support for the Vevo(R) LAZR will further translational research in developing new diagnostic tests and therapeutic interventions for traditional and emergent needs. Access to this unique scanner for the wide research community at the University of Pennsylvania and other institutions in the region will promote interdisciplinary interactions between research groups, as well as facilitate the integration of research and education. In short, availability of the Vevo(R) LAZR will have a significant impact on ongoing and future biomedical research at the University of Pennsylvania.

描述（由申请人提供）：此资助申请是购买Vevo（R）LAZR扫描仪的请求，用于高分辨率，实时3D光声和超声成像。该扫描仪将成为宾夕法尼亚大学（UPenn）小动物成像设施（SAIF）的一部分，并将被校园内不同部门的研究人员用作共享资源。费城地区拥有大量基础和转化生物医学研究的一流机构。我们将推广该工具，并将其提供给费城地区的其他机构。Vevo（R）LAZR是一种最先进的双模态扫描仪，集成了光声和高频超声。它将光学成像的灵敏度与超声的分辨率和穿透深度相结合。它是一个具有多个应用程序的单一平台，包括传统模式（如多扫描和多普勒成像）以及更高级的应用程序（如弹性成像、微血管成像、血氧饱和度和血红蛋白测量），沿着。该多功能仪器将支持大约20项研究提案。它的运作将由一个经验丰富的团队管理，该团队在动物和成像研究方面拥有良好的记录。对Vevo（R）LAZR的资金支持将进一步推动转化研究，开发新的诊断测试和治疗干预措施，以满足传统和紧急需求。宾夕法尼亚大学和该地区其他机构的广泛研究社区使用这种独特的扫描仪将促进研究小组之间的跨学科互动，并促进研究和教育的整合。简而言之，Vevo（R） LAZR将对宾夕法尼亚大学正在进行的和未来的生物医学研究产生重大影响。

项目成果

Wulff in a cage gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging.

• DOI: 10.1039/c8nr05203d
• 发表时间: 2018-10-21
• 期刊: Nanoscale
• 影响因子: 6.7
• 作者: Hajfathalian M ;Amirshaghaghi A ;Naha PC ;Chhour P ;Hsu JC ;Douglas K ;Dong Y ;Sehgal CM ;Tsourkas A ;Neretina S ;Cormode DP
• 通讯作者: Cormode DP