COBRE Center on Opioids and Overdose

COBRE 阿片类药物和药物过量中心

• 批准号: 9766319
• 负责人: JOSIAH D RICH
• 金额: $ 242.82万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9766319
• 关键词: Accidental Injury; Acute; Address; Affect; Analgesics; Area; Benefits and Risks; Caring; Centers for Disease Control and Prevention (U.S.); Centers of Research Excellence; Cessation of life; Clinical Research; Collaborations; Consultations; Country; Data; Data Management Resources; Discipline; Disease; Doctor of Philosophy; Education and Outreach; Ensure; Epidemic; Ethics; Faculty; Fentanyl; Fetus; Funding; Goals; Health Technology; Heroin; Hospitals; Imprisonment; Individual; Infrastructure; Institution; Joints; Knowledge; Leadership; Link; Mentors; Mentorship; Methodology; Motivation; Musculoskeletal Pain; Neonatal Abstinence Syndrome; Opiate Addiction; Opioid; Overdose; Pattern; Pharmaceutical Preparations; Policies; Population; Prevention; Prevention approach; Public Health; Research; Research Activity; Research Design; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Rhode Island; Scientist; Senior Scientist; Services; Strategic Planning; Surgeon; Translational Research; United States; United States National Institutes of Health; Vehicle crash; Vulnerable Populations; Work; career; career development; cohort; contingency management; data visualization; early-career faculty; effective intervention; high risk population; implementation science; innovation; mHealth; member; multidisciplinary; named group; opioid misuse; opioid overdose; opioid use disorder; organizational structure; prescription opioid; prevent; programs; recruit; support tools

PROJECT SUMMARY We propose to build and sustain the Center of Biomedical Research Excellence (COBRE) on Opioids and Overdose at Rhode Island Hospital and affiliated research institutions. The motivation for this effort lies in the tremendous need for greater scientific understanding of the mechanisms underpinning vulnerability to opioid use disorder and a need for more effective interventions to treat and prevent opioid misuse and overdose. We will approach these challenges through ongoing, cooperative partnership among senior scientists and early career investigators across several complementary disciplines. We propose a unique and innovative mentoring strategy that, in addition to primary project advising, will provide junior faculty members with specialized mentorship and services that empowers investigators to influence policy and practice through their research. Moreover, we will build four interdisciplinary cores that will provide infrastructure, consultation, and additional support services to ensure the successful career development of our Project Leaders. The long-term goal of the Center is to develop and sustain a critical mass of investigators specializing in opioids and overdose that benefits affected populations and enhances the competitiveness of affiliated investigators. The objective of this proposal is to establish and build the COBRE Center and to support the research activities of junior Project Leaders to ensure their transition to R01-funded scientists. There are two Specific Aims—one related to the establishment of a new disease-specific research center, and one encompassing four Research Projects that are linked by the themes of opioids and overdose. Aim 1: Establish the cores needed to develop and sustain a thematic multidisciplinary center of research excellence on opioids and overdose. Four cores will be created to achieve this aim: an Administrative Core, a Data and Research Methods (DRM) Core, a Translational and Transformative (T2) Core, and a Special Populations (SP) Core. Aim 2: Support the selection, mentorship, and career development of early career faculty Project Leaders. The four initial research projects are: Project 1: (Beaudoin) “Informed opioid prescribing for acute musculoskeletal pain after motor vehicle collision: A support tool for assessing risks and benefits of analgesic medications before prescribing (STAAMP),” Project 2: (Claborn) “Prevention of Opioid Overdose following Incarceration: Leveraging Mobile Health Technology,” Project 3: (Becker) “Contingency Management in Combination with MAT for Opioid Use Disorders,” and Project 4: (Czynski) “Neonatal Abstinence Syndrome (NAS): Fetus to First Years.” The proposed center will bring together an interdisciplinary group of accomplished senior scientists, promising junior investigators, and distinguished advisors and collaborators to work closely together to establish a center of excellence in an area of clinical research that is of critical public health importance.

项目概要 我们建议建立和维持阿片类药物和药物生物医学卓越研究中心 (COBRE) 罗德岛医院及附属研究机构服药过量。这项努力的动机在于 迫切需要对阿片类药物脆弱性的机制有更深入的科学了解 使用障碍以及需要更有效的干预措施来治疗和预防阿片类药物滥用和过量。我们 将通过资深科学家和早期科学家之间持续的合作伙伴关系来应对这些挑战 跨多个互补学科的职业调查员。我们提出独特且创新的指导 除主要项目咨询外，还将为初级教员提供专门的战略 指导和服务使研究人员能够通过研究影响政策和实践。 此外，我们将建立四个跨学科核心，提供基础设施、咨询和其他服务。 支持服务，以确保我们的项目负责人成功的职业发展。长期目标是 该中心的目的是培养和维持足够数量的专门研究阿片类药物和药物过量的研究人员， 使受影响人群受益并提高附属调查人员的竞争力。此举的目的 提案是建立和建设 COBRE 中心并支持初级项目的研究活动 领导者确保他们过渡到 R01 资助的科学家。有两个具体目标——一个与 建立一个新的特定疾病研究中心，该中心包含四个研究项目， 与阿片类药物和药物过量的主题联系在一起。目标 1：建立发展和维持 阿片类药物和药物过量专题多学科卓越研究中心。将创建四个核心 实现这一目标：管理核心、数据和研究方法 (DRM) 核心、转化和 变革 (T2) 核心和特殊人群 (SP) 核心。目标 2：支持选择、指导和 早期职业教师项目负责人的职业发展。四个初步研究项目是： 项目 1： （Beaudoin）“针对机动车碰撞后急性肌肉骨骼疼痛的阿片类药物处方：一种支持 处方前评估镇痛药物风险和益处的工具 (STAAMP)，”项目 2： (Claborn)“预防监禁后阿片类药物过量：利用移动医疗技术” 项目 3：（Becker）“结合 MAT 治疗阿片类药物使用障碍的应急管理”，以及 项目 4：（Czynski）“新生儿禁欲综合症 (NAS)：胎儿到第一年”。拟议的中心将 汇集了一个由有成就的资深科学家、有前途的初级研究人员组成的跨学科小组， 杰出的顾问和合作者密切合作，在某个领域建立卓越中心 对公共卫生具有重要意义的临床研究。