COBRE Center on Opioids and Overdose

COBRE 阿片类药物和药物过量中心

• 批准号: 10711725
• 负责人: JOSIAH D RICH
• 金额: $ 249.86万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711725
• 关键词: Accidental Injury; Address; Affect; Area; Award; COVID-19 pandemic; Caring; Centers of Research Excellence; Cessation of life; Clinical Research; Collaborations; Consultations; Country; Data; Data Management Resources; Dedications; Discipline; Disease; Doctor of Philosophy; Education and Outreach; Ensure; Ethics; Faculty; Funding; Goals; Hospitals; Individual; Infrastructure; Institution; Investments; Joints; Knowledge; Lead; Leadership; Link; Mentors; Mentorship; Methodology; Motivation; Opioid; Overdose; Pattern; Peer Review; Phase; Pilot Projects; Placebos; Policies; Population; Prevention approach; Public Health; Publications; Research; Research Activity; Research Design; Research Infrastructure; Research Methodology; Research Peer Review; Research Personnel; Research Project Grants; Research Support; Resources; Rhode Island; Scientist; Senior Scientist; Services; Strategic Planning; Translational Research; Underserved Population; United States; United States National Institutes of Health; Vehicle crash; Vulnerable Populations; Work; career; career development; chronic pain patient; community engaged research; community reintegration; data visualization; early-career faculty; effective intervention; empowerment; fentanyl use; heroin use; high risk population; implementation science; improved; innovation; member; multidisciplinary; open label; opioid misuse; opioid overdose; opioid use; opioid use disorder; organizational structure; prescription opioid; prevent; programs; recruit

Project Summary/Abstract We propose to further strengthen and sustain the successful Center of Biomedical Research Excellence (COBRE) on Opioids and Overdose at Rhode Island Hospital and affiliated research institutions. The motivation for this effort lies in the ongoing tremendous need for greater scientific understanding of the mechanisms underpinning vulnerability to opioid use and overdose and a need for more effective interventions to treat and prevent opioid misuse and overdose. We will approach these challenges through ongoing, cooperative partnership among senior scientists and early career investigators across several complementary disciplines. We will continue our unique and innovative mentoring strategy that, in addition to primary project advising, provides junior faculty members with specialized mentorship and services that empowers investigators to influence policy and practice through their research. Moreover, our four interdisciplinary cores provide infrastructure, consultation, and additional support services to ensure the successful career development of our Project Leaders. The long-term goal of the Center is to strengthen and sustain a critical mass of investigators specializing in opioids and overdose that benefits affected populations and enhances the competitiveness of affiliated investigators. The objective of this proposal is to strengthen and continue to develop the COBRE Center and to support the research activities of junior Project Leaders to ensure their transition to R01-funded scientists and enhance the critical mass of researchers. There are two Specific Aims—one related to the strengthening of our disease-specific research center, and one encompassing three Research Projects that are linked by the themes of opioids and overdose. Aim 1: Strengthen the cores needed to further develop and sustain our thematic multidisciplinary center of research excellence on opioids and overdose. Four cores will continue to strive to achieve this aim: our Administrative Core, Data and Research Methods Core, Translational and Transformative Core, and Community Engaged Research Core. Aim 2: Support the selection, mentorship, and career development of early career faculty Project Leaders. The three initial research projects are: Project 1: Nicole Weiss, PhD - Prediction of Return to Opioid Use During Immediate Community Reintegration, Project 2: Michael Bernstein, PhD- Optimizing Open Label Placebos for Chronic Pain Patients, and Project 3: new RPL to be assigned; R01 notice of award was received, effective 9/30/22, for originally planned researcher. The Center brings together an interdisciplinary group of accomplished senior scientists, promising junior investigators, and distinguished advisors and collaborators to work collectively to strengthen our center of excellence in an area of clinical research that is of critical public health importance.

项目概要/摘要 我们建议进一步加强和维持成功的生物医学研究卓越中心 (COBRE) 罗德岛医院及其附属研究机构的阿片类药物和过量用药。这 这项努力的动机在于对更深入地科学理解的持续巨大需求 阿片类药物使用和过量的脆弱性机制以及需要更有效的干预措施 治疗和预防阿片类药物滥用和过量。我们将通过持续的、 资深科学家和早期职业研究人员之间的合作伙伴关系跨越几个互补的领域 学科。我们将继续我们独特和创新的指导策略，除了主要项目之外 提供咨询，为初级教员提供专门的指导和服务，以增强他们的能力 调查人员通过他们的研究影响政策和实践。此外，我们的四个跨学科核心 提供基础设施、咨询和额外的支持服务，以确保成功的职业生涯 我们的项目负责人的发展。该中心的长期目标是加强和维持关键的 大量专门研究阿片类药物和过量用药的研究人员，这使受影响的人群受益并增强了 附属研究人员的竞争力。该提案的目的是加强并继续 发展 COBRE 中心并支持初级项目负责人的研究活动，以确保他们 向 R01 资助的科学家过渡并增强研究人员的临界质量。具体有两个 目标——一个与加强我们的特定疾病研究中心有关，一个包含三个 以阿片类药物和过量用药为主题的研究项目。目标1：强化核心 需要进一步发展和维持我们的专题多学科卓越研究中心 阿片类药物和过量。四个核心将继续努力实现这一目标：我们的管理核心、数据核心 和研究方法核心、转化和变革核心以及社区参与研究 核。目标 2：支持早期职业教师项目的选拔、指导和职业发展 领导们。三个初始研究项目是： 项目 1：Nicole Weiss 博士 - 预测阿片类药物回归 在立即重新融入社区期间使用，项目 2：Michael Bernstein 博士 - 优化开放标签 慢性疼痛患者的安慰剂，以及项目 3：分配新的 RPL； R01 中标通知书是 已收到，于 2022 年 9 月 30 日生效，适用于原计划的研究人员。该中心汇集了跨学科的 一群有成就的资深科学家、有前途的初级研究人员和杰出的顾问 合作者共同努力，加强我们在临床研究领域的卓越中心 至关重要的公共卫生重要性。

项目成果

Multi-level influences on increased overdose risk behaviors during the COVID-19 pandemic among people who use drugs in Rhode Island: a qualitative investigation.

• DOI: 10.1186/s12954-023-00741-w
• 发表时间: 2023-02-04
• 期刊: HARM REDUCTION JOURNAL
• 影响因子: 4.4
• 作者: Frueh, Lisa;Collins, Alexandra B. B.;Newman, Roxxanne;Barnett, Nancy P. P.;Rich, Josiah D. D.;Clark, Melissa A. A.;Marshall, Brandon D. L.;Macmadu, Alexandria
• 通讯作者: Macmadu, Alexandria

Buprenorphine Telehealth Treatment Initiation and Follow-Up During COVID-19.

• DOI: 10.1007/s11606-021-07249-8
• 发表时间: 2022-04
• 期刊: Journal of general internal medicine
• 影响因子: 5.7
• 作者: Samuels EA;Khatri UG;Snyder H;Wightman RS;Tofighi B;Krawczyk N
• 通讯作者: Krawczyk N

Racial and ethnic differences in emotion regulation: A systematic review.

情绪调节中的种族和种族差异：系统评价。

• DOI: 10.1002/jclp.23284
• 发表时间: 2022-05
• 期刊: JOURNAL OF CLINICAL PSYCHOLOGY
• 影响因子: 3
• 作者: Weiss, Nicole H.;Thomas, Emmanuel D.;Schick, Melissa R.;Reyes, Miranda E.;Contractor, Ateka A.
• 通讯作者: Contractor, Ateka A.

The differential relation of trauma types with negative and positive emotion dysregulation.

• DOI: 10.1080/10615806.2021.1964072
• 发表时间: 2022-07
• 期刊: ANXIETY STRESS AND COPING
• 影响因子: 3.7
• 作者: Berfield, Jillian B.;Goncharenko, Svetlana;Forkus, Shannon R.;Contractor, Ateka A.;Weiss, Nicole H.
• 通讯作者: Weiss, Nicole H.

Psychometric Evaluation of the Posttrauma Risky Behaviors Questionnaire: Item Response Theory Analyses.

• DOI: 10.1177/10731911211036760
• 发表时间: 2022-12
• 期刊: ASSESSMENT
• 影响因子: 3.8
• 作者: Natesan Batley, Prathiba;Contractor, Ateka A.;Weiss, Nicole H.;Compton, Sidonia E.;Price, Matthew
• 通讯作者: Price, Matthew