COBRE Center on Opioids and Overdose

COBRE 阿片类药物和药物过量中心

• 批准号: 10006576
• 负责人: JOSIAH D RICH
• 金额: $ 237.67万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006576
• 关键词: Accidental Injury; Acute; Address; Affect; Analgesics; Area; Benefits and Risks; Caring; Centers for Disease Control and Prevention (U.S.); Centers of Research Excellence; Cessation of life; Clinical Research; Collaborations; Consultations; Country; Data; Data Management Resources; Discipline; Disease; Doctor of Philosophy; Education and Outreach; Ensure; Epidemic; Ethics; Faculty; Fentanyl; Fetus; Funding; Goals; Health Technology; Heroin; Hospitals; Imprisonment; Individual; Infrastructure; Institution; Joints; Knowledge; Leadership; Link; Mentors; Mentorship; Methodology; Motivation; Musculoskeletal Pain; Neonatal Abstinence Syndrome; Opiate Addiction; Opioid; Overdose; Pattern; Pharmaceutical Preparations; Policies; Population; Prevention; Prevention approach; Public Health; Research; Research Activity; Research Design; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Rhode Island; Scientist; Senior Scientist; Services; Strategic Planning; Surgeon; Translational Research; United States; United States National Institutes of Health; Vehicle crash; Vulnerable Populations; Work; career; career development; cohort; contingency management; data visualization; early-career faculty; effective intervention; high risk population; implementation science; innovation; mHealth; member; multidisciplinary; named group; opioid misuse; opioid overdose; opioid use disorder; organizational structure; prescription opioid; prevent; programs; recruit; support tools

PROJECT SUMMARY We propose to build and sustain the Center of Biomedical Research Excellence (COBRE) on Opioids and Overdose at Rhode Island Hospital and affiliated research institutions. The motivation for this effort lies in the tremendous need for greater scientific understanding of the mechanisms underpinning vulnerability to opioid use disorder and a need for more effective interventions to treat and prevent opioid misuse and overdose. We will approach these challenges through ongoing, cooperative partnership among senior scientists and early career investigators across several complementary disciplines. We propose a unique and innovative mentoring strategy that, in addition to primary project advising, will provide junior faculty members with specialized mentorship and services that empowers investigators to influence policy and practice through their research. Moreover, we will build four interdisciplinary cores that will provide infrastructure, consultation, and additional support services to ensure the successful career development of our Project Leaders. The long-term goal of the Center is to develop and sustain a critical mass of investigators specializing in opioids and overdose that benefits affected populations and enhances the competitiveness of affiliated investigators. The objective of this proposal is to establish and build the COBRE Center and to support the research activities of junior Project Leaders to ensure their transition to R01-funded scientists. There are two Specific Aims—one related to the establishment of a new disease-specific research center, and one encompassing four Research Projects that are linked by the themes of opioids and overdose. Aim 1: Establish the cores needed to develop and sustain a thematic multidisciplinary center of research excellence on opioids and overdose. Four cores will be created to achieve this aim: an Administrative Core, a Data and Research Methods (DRM) Core, a Translational and Transformative (T2) Core, and a Special Populations (SP) Core. Aim 2: Support the selection, mentorship, and career development of early career faculty Project Leaders. The four initial research projects are: Project 1: (Beaudoin) “Informed opioid prescribing for acute musculoskeletal pain after motor vehicle collision: A support tool for assessing risks and benefits of analgesic medications before prescribing (STAAMP),” Project 2: (Claborn) “Prevention of Opioid Overdose following Incarceration: Leveraging Mobile Health Technology,” Project 3: (Becker) “Contingency Management in Combination with MAT for Opioid Use Disorders,” and Project 4: (Czynski) “Neonatal Abstinence Syndrome (NAS): Fetus to First Years.” The proposed center will bring together an interdisciplinary group of accomplished senior scientists, promising junior investigators, and distinguished advisors and collaborators to work closely together to establish a center of excellence in an area of clinical research that is of critical public health importance.

项目总结 我们建议建立和维持生物医学卓越研究中心(COBRE)关于阿片类药物和 罗德岛医院及其附属研究机构服药过量。这一努力的动机在于 迫切需要对阿片类药物易感性的机制有更深入的科学了解 使用障碍和需要更有效的干预措施来治疗和预防阿片类药物滥用和过量。我们 将通过资深科学家之间持续的合作伙伴关系和早期 跨几个互补学科的职业调查员。我们提出了一种独特的、创新的指导 除了主要的项目建议外，还将为初级教员提供专门的 指导和服务，使研究人员能够通过他们的研究影响政策和实践。 此外，我们还将构建四个跨学科核心，以提供基础设施、咨询和其他 支持服务，以确保我们的项目负责人成功的职业发展。的长期目标是 该中心将发展和维持一批专门研究阿片类药物和过量用药的调查人员 使受影响的人群受益，并提高附属调查人员的竞争力。这样做的目的是 建议建立和建设科布雷中心，支持初级项目的研究活动 领导人确保他们过渡到R01资助的科学家。有两个具体的目标-一个与 建立一个新的疾病研究中心，其中一个包括四个研究项目， 由阿片类药物和过量用药这两个主题联系在一起。目标1：建立发展和维持 关于阿片类药物和过量用药的卓越研究的多学科专题中心。将创建四个核心，以 实现这一目标：管理核心、数据和研究方法(DRM)核心、翻译和 变革性(T2)核心和特殊群体(SP)核心。目标2：支持选拔、指导和 早期职业教师项目领导者的职业发展。四个初步研究项目是：项目1： (Beaudoin)：对机动车碰撞后急性肌肉骨骼疼痛的知情阿片类药物处方：一种支持 处方前止痛药风险和收益评估工具(STAAMP)，“项目2： “预防监禁后阿片类药物过量：利用移动医疗技术，” 项目3：(Becker)“阿片类药物使用障碍的应急管理与MAT相结合”，以及 项目4：(Czynski)“新生儿禁欲综合症(NAS)：胎儿至一岁。”拟建的中心将 聚集了一个由有成就的资深科学家组成的跨学科小组，他们是有前途的初级调查人员，以及 杰出的顾问和合作者紧密合作，在某一领域建立卓越中心 对公共卫生具有重要意义的临床研究。