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Novel optical probe for dopamine release in neural circuits

用于神经回路中多巴胺释放的新型光学探针

基本信息

批准号：
9766299
负责人：
Marla Feller
金额：
$ 21.36万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9766299
关键词：
Acute Address Adult Amacrine Cells Axon Behavior Biological Models Biomimetics Brain Calcium Cells Chemicals Collaborations Corpus striatum structure Custom Development Dopamine Electrical Synapse Engineering Exposure to Fluorescence Functional disorder Goals Image In Vitro Interneurons Knockout Mice Light Light Adaptations Lighting Measures Mediating Microscope Modernization Monitor Mus Nervous system structure Neuromodulator Neurosciences Optics Pathologic Pharmacology Phase Photoreceptors Photosensitivity Physiological Play Polymers Positioning Attribute Research Retina Retinal Retinal Ganglion Cells Rewards Role Scanning Signal Transduction Synapses Techniques Technology Testing Time Tissues Whole-Cell Recordings Work base design imaging modality in vivo innovative technologies melanopsin millisecond motivated behavior motor control nanosensors nervous system disorder neural circuit neuroregulation neurotransmission novel professor relating to nervous system response reuptake sensor single walled carbon nanotube spatiotemporal symposium two photon microscopy two-photon

项目摘要

A major focus of modern neuroscience is understanding the role of neuromodulators in neural circuit function and development, in behavior, and their dysfunction in neurological disease. Neural circuit research has been revolutionized by powerful new optical techniques. Here we propose to use new near-infrared optical nanosensor technology to image dopamine. As a proof of principle, we will use this sensor to monitor dopamine release under physiological conditions in both the developing and adult retinas. The ability to combine neuromodulator imaging with other physiological measures in a well-defined neural circuit will greatly advance our understanding of neuromodulation, allowing us to elucidate its many impacts on normal and pathological circuits.

现代神经科学的一个主要焦点是了解神经调质的作用神经回路功能和发育，行为，以及他们的功能障碍，神经系统疾病神经回路研究已经被强大的新技术彻底改变，光学技术在这里，我们提出使用新的近红外光学纳米传感器技术来成像多巴胺。作为原理证明，我们将使用该传感器来在生理条件下监测多巴胺的释放，成人视网膜将联合收割机神经调质成像与其他生理学检查相结合的能力在一个定义明确的神经回路中进行测量将大大促进我们对神经调节，使我们能够阐明其对正常和病理的许多影响，电路.