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Novel optical probe for dopamine release in neural circuits

Novel optical probe for dopamine release in neural circuits
用于神经回路中多巴胺释放的新型光学探针
批准号：
9766299
负责人：
Marla Feller
金额：
$21.36万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
项目状态：
已结题
起止时间：
2018-09-01 至 2021-08-31
来源：
https://reporter.nih.gov/project-details/9766299
关键词：
AcuteAddressAdultAmacrine CellsAxonBehaviorBiological ModelsBiomimeticsBrainCalciumCellsChemicalsCollaborationsCorpus striatum structureCustomDevelopmentDopamineElectrical SynapseEngineeringExposure toFluorescenceFunctional disorderGoalsImageIn VitroInterneuronsKnockout MiceLightLight AdaptationsLightingMeasuresMediatingMicroscopeModernizationMonitorMusNervous system structureNeuromodulatorNeurosciencesOpticsPathologicPharmacologyPhasePhotoreceptorsPhotosensitivityPhysiologicalPlayPolymersPositioning AttributeResearchRetinaRetinalRetinal Ganglion CellsRewardsRoleScanningSignal TransductionSynapsesTechniquesTechnologyTestingTimeTissuesWhole-Cell RecordingsWorkbasedesignimaging modalityin vivoinnovative technologiesmelanopsinmillisecondmotivated behaviormotor controlnanosensorsnervous system disorderneural circuitneuroregulationneurotransmissionnovelprofessorrelating to nervous systemresponsereuptakesensorsingle walled carbon nanotubespatiotemporalsymposiumtwo photon microscopytwo-photon

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中文摘要
翻译
现代神经科学的一个主要焦点是理解神经调节剂的作用
英文摘要
A major focus of modern neuroscience is understanding the role of neuromodulators in neural circuit function and development, in behavior, and their dysfunction in neurological disease. Neural circuit research has been revolutionized by powerful new optical techniques. Here we propose to use new near-infrared optical nanosensor technology to image dopamine. As a proof of principle, we will use this sensor to monitor dopamine release under physiological conditions in both the developing and adult retinas. The ability to combine neuromodulator imaging with other physiological measures in a well-defined neural circuit will greatly advance our understanding of neuromodulation, allowing us to elucidate its many impacts on normal and pathological circuits.
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