用于神经回路中多巴胺释放的新型光学探针-猫眼课题宝

用于神经回路中多巴胺释放的新型光学探针

批准号：

9766299

负责人：

Marla Feller

金额：

$21.36万

依托单位：

UNIVERSITY OF CALIFORNIA BERKELEY

依托单位国家：

美国

项目类别：

财政年份：

2018

资助国家：

美国

项目状态：

已结题

起止时间：

2018-09-01 至 2021-08-31

来源：

https://reporter.nih.gov/project-details/9766299

关键词：

Acute Address Adult Amacrine Cells Axon Behavior Biological Models Biomimetics Brain Calcium Cells Chemicals Collaborations Corpus striatum structure Custom Development Dopamine Electrical Synapse Engineering Exposure to Fluorescence Functional disorder Goals Image In Vitro Interneurons Knockout Mice Light Light Adaptations Lighting Measures Mediating Microscope Modernization Monitor Mus Nervous system structure Neuromodulator Neurosciences Optics Pathologic Pharmacology Phase Photoreceptors Photosensitivity Physiological Play Polymers Positioning Attribute Research Retina Retinal Retinal Ganglion Cells Rewards Role Scanning Signal Transduction Synapses Techniques Technology Testing Time Tissues Whole-Cell Recordings Work base design imaging modality in vivo innovative technologies melanopsin millisecond motivated behavior motor control nanosensors nervous system disorder neural circuit neuroregulation neurotransmission novel professor relating to nervous system response reuptake sensor single walled carbon nanotube spatiotemporal symposium two photon microscopy two-photon

项目摘要

项目成果

Marla Feller的其他基金

相似基金

相关文献

中文摘要

翻译

现代神经科学的一个主要焦点是了解神经调节剂的作用。在神经回路的功能和发育中，在行为上，在他们的功能障碍中神经系统疾病。强大的新技术给神经电路研究带来了革命性的变化光学技术。在这里，我们建议使用新的近红外光学纳米传感器成像多巴胺的技术。作为原则上的证明，我们将使用这个传感器来在发育和发育过程中监测生理条件下的多巴胺释放成人视网膜。将神经调节剂成像与其他生理学检查相结合的能力在定义明确的神经回路中进行测量将极大地促进我们对神经调节，使我们能够阐明它对正常和病理的许多影响电路。

英文摘要

A major focus of modern neuroscience is understanding the role of neuromodulators in neural circuit function and development, in behavior, and their dysfunction in neurological disease. Neural circuit research has been revolutionized by powerful new optical techniques. Here we propose to use new near-infrared optical nanosensor technology to image dopamine. As a proof of principle, we will use this sensor to monitor dopamine release under physiological conditions in both the developing and adult retinas. The ability to combine neuromodulator imaging with other physiological measures in a well-defined neural circuit will greatly advance our understanding of neuromodulation, allowing us to elucidate its many impacts on normal and pathological circuits.

期刊论文(0)

专著(0)

科研奖励(0)

会议论文