Development of direction selectivity in the retina
视网膜方向选择性的发展
基本信息
- 批准号:7634649
- 负责人:
- 金额:$ 35.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-01 至 2011-06-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAgeAmacrine CellsAnimalsArtsAutomobile DrivingCalciumCell physiologyCellsChemicalsCongenital AbnormalityDevelopmentDorsalExposure toFetusFluorescent DyesFutureGenerationsGoalsImageImaging TechniquesInhibitory SynapseInterneuronsLaboratoriesLeadLeftMediatingModelingMotionMusNervous system structureNeurologicNosePhysiologyPlayProteinsReflex actionReportingResearchRetinaRetinalRoleSideSynapsesTechniquesTestingTimeTransgenic MiceTreesVisionVisualVisual FieldsVisual system structureWorkassay developmentdensitydesignexperienceganglion cellinsightneural circuitneuropathologyobject motionoculomotorreceptive fieldrelating to nervous systemresearch studyresponsevision development
项目摘要
Direction-selective ganglion cells respond strongly to an image moving in the
preferred direction and weakly to an image moving in the opposite, or null direction, and
are critical for driving ocular-motor reflexes that stabilize images on the retina as we
move through a visual scene. The preferred direction of direction-selective ganglion cells
cluster along the cardinal directions (up, down, left and right) and the direction-selective
ganglion cells sensitive to each cardinal direction are organized into mosaics such that
at each point in space, each direction of motion is represented. The predominant model
for the generation of direction selectivity in the retina is that a particular class of
interneurons form inhibitory synapses on the null side of the dendritic tree of directionselective
ganglion cells. The mechanisms that instruct the emergence of mosaics
comprised of cells that receive an asymmetric distribution of inhibitory inputs during
development are unknown.
Our long-term goal is to determine the mechanisms that underlie the development
of these two essential features of direction-selectivity - the circuits that underlie the null
side inhibition and the existence of direction-selective ganglion cells mosaics. In
particular, we will determine whether spontaneous retinal activity plays a critical role in
the formation of these circuits. Here we propose to use a combination of state-of-the-art
electrophysiological and imaging techniques to determine the age at which directional
circuits are established.
方向选择性神经节细胞对大脑中移动的图像反应强烈
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Marla Feller其他文献
Marla Feller的其他文献
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用于神经回路中多巴胺释放的新型光学探针
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- 资助金额:
$ 35.08万 - 项目类别:
Development of direction selectivity in the retina
视网膜方向选择性的发展
- 批准号:
7876825 - 财政年份:2009
- 资助金额:
$ 35.08万 - 项目类别:
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