Safe Direct Current for Neuroprosthetic Applications

用于神经修复应用的安全直流电

基本信息

批准号：
9765416
负责人：
Gene Yevgeny Fridman
金额：
$ 34.8万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9765416
关键词：
Action Potentials Address Advanced Development Animal Experiments Animal Model Anodes Cathodes Charge Chinchilla (genus)Cochlear Implants Consumption Contralateral Corrosion Data Development Effectiveness Electrodes Engineering Ensure Esthesia Evaluation Failure Gel Goals Head Head Movements Histologic Hydrolysis Implant Injections Ipsilateral Location Longevity Metals Microfluidic Microchips Microfluidics Motion Nerve Nerve Block Nervous system structure Neurons Operative Surgical Procedures Pacemakers Pain Pathologic Performance Perilymph Peripheral Nerves Physiologic pulse Physiological Prosthesis Proxy Research Rotation Safety Saline Specimen Spinal Cord Stimulus System Technology Testing Therapeutic Tissues Translations Tube Vestibular Labyrinth Work chronic pain clinical application deep brain stimulator design electric impedance equilibration disorder experimental study implantable device improved innovation miniaturize neural prosthesis neurophysiology neuroprosthesis neuroregulation novel prototype public health relevance relating to nervous system response retina implantation stem vestibular prosthesis vestibulo-ocular reflex voltage

项目摘要

DESCRIPTION (provided by applicant): The central goal of this project is to advance the therapeutic applications and the development of an exciting novel neuroprosthetic technology, Safe Direct Current Stimulation (SDCS). Direct current (DC) compared to biphasic charge balanced pulses normally used by neural prostheses to interface to the nervous system, can more naturally control neural activity. Unlike biphasic current pulses used to excite neurons, DC can excite, inhibit, and modulate sensitivity of neurons. However using DC for implantable prosthetic applications has not been possible due to the DC's inherent violation of the charge injection safety constraints at the metal electrode interfaces. Safe DC overcomes these constraints and opens a new avenue for research into exciting possibilities of using DC to interface to the nervous system. We will optimize the use of safe DC to improve the performance of a vestibular prosthesis for those suffering from balance disorders. Vestibular prostheses encounter difficulty encoding head motion away from the implanted vestibular labyrinth because encoding this motion requires inhibition of spontaneous activity of the nerve. We obtained preliminary data in a chinchilla animal model showing that modulating the amplitude and polarity of safe DC could encode both ipsilateral and contralateral head rotations. Here we propose to understand and overcome the hurdles that we encountered in our preliminary experiments stemming from the key safe DC stimulation challenge: the reversal of neural response as a function of increased safe DC intensity. That is, anodic (positive) stimulation causes inhibition at low DC intensities but excitation at higher intensities; and cathodic (negative) stimulation causes excitation at low DC intensities but inhibition as the amplitude increases. In the vestibular prosthetic stimulation this effect imposes a limit on the velocity of encoding head motion. We also propose to advance the SDCS technology by identifying and solving the key technical challenges with a miniaturized SDCS to improve longevity and power consumption. Aim 1) Improve the vestibular prosthetic encoding of head motion. We will investigate the origin of the response reversal and improve the head velocity encoding by eliminating or reducing the reversal with a bipolar stimulation paradigm. Aim 2) Examine the safety of SDCS. We will examine the physiological and histological limits of safe DC stimulation in chinchillas stimulated for 60 days. Aim 3) Address key technical challenges associated with longevity and low power consumption of the miniaturized SDCS.

描述（由应用程序提供）：该项目的核心目标是推进一种令人兴奋的新型神经假体技术，安全直接电流刺激（SDC）的治疗应用和开发。与通常由神经前体使用的双相电荷平衡脉冲与神经系统接口相比，直流电流（DC）可以更自然地控制神经元活性。与用于激发神经元的双相电流脉冲不同，DC可以令人兴奋，抑制和调节神经元的灵敏度。但是，由于DC继承违反了金属电极界面处的电荷入射安全限制，因此不可能使用DC进行植入式假体应用。安全的DC克服了这些约束，并为使用DC与神经系统接口的令人兴奋的可能性开辟了新的途径。我们将优化使用安全DC的使用，以改善患有平衡疾病的人的前庭假体的性能。前庭假体会遇到远离植入前庭迷宫的困难编码头部运动，因为编码这种运动需要抑制神经的赞助活动。我们在龙猫动物模型中获得了初步数据，表明调节安全直流的放大器和极性可以编码同侧和对侧头部旋转。在这里，我们建议理解和克服我们在首次实验中遇到的障碍，这是由于关键的安全直流模拟挑战所引起的：中性响应的逆转是安全DC强度增加的函数。也就是说，阳极（正）模拟会在低直流强度下引起抑制作用，但在较高强度下引起兴奋。阴极（阴性）模拟在低直流强度下引起兴奋，但随着放大器的增加而抑制。在前庭假体模拟中，这种效果不可能限制编码头运动的速度。我们还建议通过通过微型SDC来确定和解决关键的技术挑战来提高SDCS技术，以改善寿命和功耗。目标1）改善头部运动的前庭假体编码。我们将通过消除或减少双极刺激范式来消除或减少反转来研究响应逆转的起源，并改善头部速度编码。目标2）检查SDC的安全性。我们将检查刺激60天的龙猫中安全直流模拟的物理和组织学限制。目标3）应对与长寿和低功耗相关的关键技术挑战。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Electronics for a Safe Direct Current Stimulator.

用于安全直流刺激器的电子器件。

DOI：
10.1109/biocas.2017.8325191
发表时间：
2017
期刊：
IEEE Biomedical Circuits and Systems Conference : healthcare technology : [proceedings]. IEEE Biomedical Circuits and Systems Conference
影响因子：
0
作者：
Ou,Patrick;Fridman,Gene
通讯作者：
Fridman,Gene

Low Cost, Ease-of-Access Fabrication of Microfluidic Devices Using Wet Paper Molds.

DOI：
10.3390/mi13091408
发表时间：
2022-08-27
期刊：
Micromachines
影响因子：
3.4
作者：
Thakur R;Fridman GY
通讯作者：
Fridman GY

Differential expression of voltage-gated sodium channels in afferent neurons renders selective neural block by ionic direct current.

DOI：
10.1126/sciadv.aaq1438
发表时间：
2018-04
期刊：
Science advances
影响因子：
13.6
作者：
Yang F;Anderson M;He S;Stephens K;Zheng Y;Chen Z;Raja SN;Aplin F;Guan Y;Fridman G
通讯作者：
Fridman G

Predicting Response of Spontaneously Firing Afferents to Prosthetic Pulsatile Stimulation.

预测自发放电传入神经对假肢脉动刺激的反应。