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Safe Direct Current for Neuroprosthetic Applications

用于神经修复应用的安全直流电

基本信息

批准号：
9765416
负责人：
Gene Yevgeny Fridman
金额：
$ 34.8万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9765416
关键词：
Action Potentials Address Advanced Development Animal Experiments Animal Model Anodes Cathodes Charge Chinchilla (genus)Cochlear Implants Consumption Contralateral Corrosion Data Development Effectiveness Electrodes Engineering Ensure Esthesia Evaluation Failure Gel Goals Head Head Movements Histologic Hydrolysis Implant Injections Ipsilateral Location Longevity Metals Microfluidic Microchips Microfluidics Motion Nerve Nerve Block Nervous system structure Neurons Operative Surgical Procedures Pacemakers Pain Pathologic Performance Perilymph Peripheral Nerves Physiologic pulse Physiological Prosthesis Proxy Research Rotation Safety Saline Specimen Spinal Cord Stimulus System Technology Testing Therapeutic Tissues Translations Tube Vestibular Labyrinth Work chronic pain clinical application deep brain stimulator design electric impedance equilibration disorder experimental study implantable device improved innovation miniaturize neural prosthesis neurophysiology neuroprosthesis neuroregulation novel prototype public health relevance relating to nervous system response retina implantation stem vestibular prosthesis vestibulo-ocular reflex voltage

项目摘要

DESCRIPTION (provided by applicant): The central goal of this project is to advance the therapeutic applications and the development of an exciting novel neuroprosthetic technology, Safe Direct Current Stimulation (SDCS). Direct current (DC) compared to biphasic charge balanced pulses normally used by neural prostheses to interface to the nervous system, can more naturally control neural activity. Unlike biphasic current pulses used to excite neurons, DC can excite, inhibit, and modulate sensitivity of neurons. However using DC for implantable prosthetic applications has not been possible due to the DC's inherent violation of the charge injection safety constraints at the metal electrode interfaces. Safe DC overcomes these constraints and opens a new avenue for research into exciting possibilities of using DC to interface to the nervous system. We will optimize the use of safe DC to improve the performance of a vestibular prosthesis for those suffering from balance disorders. Vestibular prostheses encounter difficulty encoding head motion away from the implanted vestibular labyrinth because encoding this motion requires inhibition of spontaneous activity of the nerve. We obtained preliminary data in a chinchilla animal model showing that modulating the amplitude and polarity of safe DC could encode both ipsilateral and contralateral head rotations. Here we propose to understand and overcome the hurdles that we encountered in our preliminary experiments stemming from the key safe DC stimulation challenge: the reversal of neural response as a function of increased safe DC intensity. That is, anodic (positive) stimulation causes inhibition at low DC intensities but excitation at higher intensities; and cathodic (negative) stimulation causes excitation at low DC intensities but inhibition as the amplitude increases. In the vestibular prosthetic stimulation this effect imposes a limit on the velocity of encoding head motion. We also propose to advance the SDCS technology by identifying and solving the key technical challenges with a miniaturized SDCS to improve longevity and power consumption. Aim 1) Improve the vestibular prosthetic encoding of head motion. We will investigate the origin of the response reversal and improve the head velocity encoding by eliminating or reducing the reversal with a bipolar stimulation paradigm. Aim 2) Examine the safety of SDCS. We will examine the physiological and histological limits of safe DC stimulation in chinchillas stimulated for 60 days. Aim 3) Address key technical challenges associated with longevity and low power consumption of the miniaturized SDCS.

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Low Cost, Ease-of-Access Fabrication of Microfluidic Devices Using Wet Paper Molds.

DOI：
10.3390/mi13091408
发表时间：
2022-08-27
期刊：
Micromachines
影响因子：
3.4
作者：
Thakur R;Fridman GY
通讯作者：
Fridman GY

Electronics for a Safe Direct Current Stimulator.

用于安全直流刺激器的电子器件。

DOI：
10.1109/biocas.2017.8325191
发表时间：
2017
期刊：
IEEE Biomedical Circuits and Systems Conference : healthcare technology : [proceedings]. IEEE Biomedical Circuits and Systems Conference
影响因子：
0
作者：
Ou,Patrick;Fridman,Gene
通讯作者：
Fridman,Gene

Differential expression of voltage-gated sodium channels in afferent neurons renders selective neural block by ionic direct current.

DOI：
10.1126/sciadv.aaq1438
发表时间：
2018-04
期刊：
Science advances
影响因子：
13.6
作者：
Yang F;Anderson M;He S;Stephens K;Zheng Y;Chen Z;Raja SN;Aplin F;Guan Y;Fridman G
通讯作者：
Fridman G

Predicting Response of Spontaneously Firing Afferents to Prosthetic Pulsatile Stimulation.

预测自发放电传入神经对假肢脉动刺激的反应。