Safe Direct Current Stimulator (SDCS) technology for blocking chronicperipheral pain

用于缓解慢性外周疼痛的安全直流刺激器 (SDCS) 技术

基本信息

批准号：
10610959
负责人：
Gene Yevgeny Fridman
金额：
$ 53.46万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10610959
关键词：
Action Potentials Address Agonist Anesthesia procedures Animal Experiments Animal Model Animals Artificial Implants Behavior Behavioral Biological Caliber Charge Chronic Cochlear Implants Data Data Set Devices Effectiveness Electrodes Electronics Electrophysiology (science)Esthesia Fiber Future Goals Image Implant Injections Intervention Ion Channel Ion Channel Gating Lead Ligation Longevity Measurement Metals Methodology Methods Microfluidics Modeling Movement Mus Muscle Nerve Nerve Block Nervous System Neurons Nociception Nociceptors Pacemakers Pain Pain management Performance Peripheral Peripheral Nerves Phase Physiologic pulse Rattus Research Safety Sodium Channel Spinal Spinal Cord Spinal Ganglia Spinal nerve structure System Technology Testing Therapeutic Vertebral column Work antagonist awake behavioral study chronic pain chronic pain management deep brain stimulator design experimental study histological studies improved in vivo miniaturize myelination nerve injury neural neural prosthesis neuroregulation new technology pain inhibition pain model pain sensation pain signal painful neuropathy predictive modeling retina implantation sciatic nerve sex side effect spared nerve technology development voltage

项目摘要

Project Summary The central goal of this project is to advance the therapeutic applications and the potential for using ionic direct current to interact with the nervous system. Direct current (DC) compared to biphasic charge balanced pulses normally used by neural prostheses to interface to the nervous system, can more naturally control neural activity. Unlike biphasic current pulses used to excite neurons, DC can excite, inhibit, and modulate sensitivity of neurons. While DC can be used for short durations to interact with the nervous system, chronic use of this stimulation paradigm for implantable prosthetic applications has not been possible due to the DC’s inherent violation of the charge injection safety constraints at the metal electrode interfaces. New technology, safe direct current stimulation (SDCS) overcomes these constraints and opens an additional avenue for research into exciting possibilities of using DC to interface to the nervous system. We will optimize the use of ionic DC to improve the performance of chronic pain suppression. Chronic pain suppression requires inhibiting pain carrying neurons from conducting action potentials. We obtained preliminary data in an anesthetized rat model showing that safe DC neural block at the sciatic nerve could suppress pain signals from propagating to the spinal cord, but allow normal propagation of sensation and muscle movement. Here we propose to understand the mechanism behind safe DC modulation of pain signals through anesthetized mouse and rat experiments. We will conduct the behavioral experiments to understand the effectiveness of this technology for addressing chronic pain in an awake animal. We will also conduct histological studies to investigate the biological impact of the therapy. Finally, we will advance the SDCS technology by identifying and solving the key technical challenges with a miniaturized and implantable SDCS. Aim 1. Examine the mechanism of the iDC effect on suppression of nociceptive pain. Aim 2. Examine the effects and underlying mechanisms of iDC on neuropathic pain signals. Aim 3. Behavioral experiments to study iDC for inhibition of neuropathic pain. Aim 4. Implantable SDCS technology development.

项目摘要该项目的核心目标是推进治疗应用和使用离子的潜力直流电流与神经系统相互作用。与双相电荷平衡相比，直流电流（DC）通常由神经plosthess使用的脉冲与神经系统接口，可以更自然地控制神经元活动。与用于激发神经元的双相电流脉冲不同，DC可以激发，抑制和调节灵敏度神经元。虽然DC可以在短时间内用于与神经系统相互作用，但长期使用此由于DC的继承，对植入式假体应用的刺激范式是不可能的违反金属电极界面处的电荷注入安全限制。新技术，安全直接当前刺激（SDC）克服了这些限制，并为研究开辟了额外的途径使用直流与神经系统接口的令人兴奋的可能性。我们将优化使用离子DC来改善慢性疼痛抑制的性能。慢性的抑制疼痛需要抑制从传导作用电位的神经元携带神经元的疼痛。我们获得了麻醉大鼠模型中的初步数据，表明坐骨神经的安全DC神经阻滞可以抑制从传播到脊髓的疼痛信号，但允许正常的感觉和肌肉传播移动。在这里，我们建议了解通过麻醉小鼠和大鼠实验。我们将进行行为实验，以了解这项技术可以解决清醒动物中慢性疼痛的有效性。我们还将进行组织学研究该治疗的生物学影响。最后，我们将通过通过微型和可植入的SDC来识别和解决关键的技术挑战。目标1。检查IDC效应对伤害感受疼痛的效果的机制。目标2。检查IDC对神经性疼痛信号的影响和潜在机制。目标3。研究IDC以抑制神经性疼痛的行为实验。目标4。可植入的SDCS技术开发。