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Stimulation model and experiments for a vestubular prosthesis.

前庭假体的刺激模型和实验。

基本信息

批准号：
7673322
负责人：
Gene Yevgeny Fridman
金额：
$ 2.02万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-13 至 2009-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7673322
关键词：
3-Dimensional Action Potentials Advanced Development Afferent Neurons Behavior Bilateral Brain Characteristics Chinchilla (genus)Cochlear Implants Cochlear Nerve Data Dependence Devices Disabled Persons Electric Stimulation Electrodes Equilibrium Esthesia Eye Functional disorder Goals Head Head Movements Image Implanted Electrodes Individual Laboratories Modeling Monitor Motion Nerve Neuraxis Neurons Operative Surgical Procedures Patients Pattern Performance Physiologic pulse Process Prosthesis Publishing Pulse Rates Rattus Recruitment Activity Reflex action Rotation Semicircular canal structure Series Signal Transduction Solutions Somatosensory Cortex Specificity Speech Intelligibility Stimulus Sum System Techniques Testing Time Tissues Training Vestibular Nerve Vestibular loss Work base design eye velocity functional restoration improved kinematics relating to nervous system research study response restoration vector vestibular prosthesis vestibulo-ocular reflex

项目摘要

DESCRIPTION (provided by applicant): The performance of the vestibular system can be quantified by monitoring the motion of the eyes due to the vestibular-ocular reflex (VOR) as it is being activated by applying a rotation motion to the experimental subject or by directly stimulating the semicircular canals. Our laboratory developed a vestibular prosthesis. This device contains gyroscopes that can sense motion about three axes of rotation and it has the ability to provide electrical stimulation pulses to the electrodes, attached to the device. The initial tests of this device with the electrodes implanted in the semicircular canals of chinchillas indicate that the separation between the branches of the vestibular nerve is too narrow to allow a clean stimulation signal to be delivered separately to each targeted branch of the vestibular nerve. The goal of this project is to establish the electrical stimulation paradigm which would provide a meaningful set of vestibular signals to the brain despite the signal crosstalk due to non-specific stimulation. We will examine two possible solutions to the problem of electrode interaction and adapt a spike integrator model to predict the effect of stimulus train parameters on the VOR response. Aim 1) Linear relationship between electrical stimulation and VOR response would allow us to use well- established 3D rotational kinematics to process the gyroscope signals from the prosthesis, despite electrode interaction. We hypothesize that linear relationships hold true between electrical stimulation and VOR responses. Aim 2) Low amplitude stimulation improves electrode specificity, but decreases the strength of the VOR response. High stimulation rates have been shown to introduce strong VOR response. We hypothesize that using low amplitude stimulation pulses delivered at high stimulation modulation rates will produce strong VOR responses with low electrode interaction. Aim 3) Finally, we will extend a biophysical model developed for predicting perceived intensity of stimulation pulse trains delivered to the somatosensory cortex, for the purposes of vestibular stimulation. We hypothesize that the model will provide accurate representation of VOR response to a wide variety of electrical stimulation parameters. RELEVANCE: Bilateral dysfunction of the vestibular system has debilitating effects on the patients, who are forced into a slow motion existence so as to compensate for the lack of their balance system. This study examines several techniques to enable and enhance the functioning of an implantable vestibular prosthesis.

描述（由申请人提供）：前庭系统的性能可以通过监测由于前庭眼反射（VOR）引起的眼睛运动来量化，因为它是通过向实验对象施加旋转运动或通过直接刺激半规管来激活的。我们实验室研制了一种前庭假体。该设备包含陀螺仪，可以感测围绕三个旋转轴的运动，并且能够向连接到设备的电极提供电刺激脉冲。将电极植入龙猫的半规管中的该装置的初始测试表明，前庭神经的分支之间的间隔太窄，以至于不允许将干净的刺激信号单独递送到前庭神经的每个目标分支。该项目的目标是建立电刺激范例，该范例将向大脑提供一组有意义的前庭信号，尽管由于非特异性刺激而导致的信号串扰。我们将研究两种可能的解决方案，电极相互作用的问题，并适应尖峰积分模型来预测刺激串参数对VOR响应的影响。目的1）电刺激和VOR响应之间的线性关系将允许我们使用完善的3D旋转运动学来处理来自假体的陀螺仪信号，而不管电极相互作用。我们假设电刺激和VOR反应之间存在线性关系。目的2）低幅度刺激可提高电极特异性，但降低VOR反应强度。高刺激率已被证明会引起强烈的VOR反应。我们假设使用以高刺激调制速率递送的低振幅刺激脉冲将产生具有低电极相互作用的强VOR响应。目的3）最后，我们将扩展一个生物物理模型，用于预测传递到躯体感觉皮层的刺激脉冲串的感知强度，以达到前庭刺激的目的。我们假设，该模型将提供准确的VOR响应各种各样的电刺激参数的表示。相关性：前庭系统的双侧功能障碍对患者具有衰弱的影响，患者被迫进入慢动作存在以补偿其平衡系统的缺乏。本研究探讨了几种技术来实现和增强植入式前庭假体的功能。