Feasibility Trial of Home-Based Strength Training in Endometrial Cancer Survivors

项目摘要 子宫内膜癌幸存者是一个不断增长的人群，具有高患病率的不活动和肥胖。尽管 力量训练的好处和肥胖个体功能限制的风险， 人口主要集中在减肥和有氧体育活动。少数研究表明， 测试阻力训练，但只是作为一个更大的多模式方法的一部分;因此， 阻力训练尚未确定。由于减肥干预的长期成功率低， 专注于通过阻力训练来建立力量和信心可能是一种有希望的方法， 让子宫内膜癌幸存者参与改变健康生活方式的过程。拟议的试点试验将 确定我们的家庭为基础的力量训练干预的可行性和安全性，其中包括在- 个人指导会议，然后是视频辅导。所有的设备都提供，所有的练习都可以 在家里完成。这种以家庭为基础的方法对于保护我们对农村癌症的影响力非常重要 幸存者主要成果将包括坚持锻炼会议和视频通话，以及 参与者对干预的反馈。我们还将测量人体测量学，身体成分， 功能健康、生物标志物、生活质量和自我效能。然而，试点研究的核心目的是 建立可行性，而不是测试假设，因此我们的具体目标特别侧重于 干预和措施的可行性，并将提供完善我们的协议所需的数据， 支持全面的试验

PROJECT SUMMARY Endometrial cancer survivors are a growing population with high prevalence of inactivity and obesity. Despite the benefits of strength training and the risk of functional limitations for obese individuals, interventions for this population have focused mainly on weight loss and aerobic physical activity. A small number of studies have tested resistance training, but only as part of a larger multi-modal approach; thus the specific benefits of resistance training have not been identified. Due to low long-term success rates of weight loss interventions, focusing on building strength and confidence through resistance training may be a promising approach to engaging endometrial cancer survivors in the process of health lifestyle change. The proposed pilot trial will determine the feasibility and safety of our home-based strength training intervention, which consists of an in- person instructional session followed by video coaching. All equipment is provided and all exercises can be done within the home. This home-based approach is important for preserving our reach to rural cancer survivors. Main outcomes will include adherence to the exercise sessions and the video calls, as well as participant feedback about the intervention. We will also measure anthropometrics, body composition, functional fitness, biomarkers, quality of life, and self-efficacy. However, the core purpose of a pilot study is to establish feasibility rather than to test hypotheses, therefore our specific aims focus specifically on the feasibility of both the intervention and the measures and will provide the data needed to refine our protocols to support a fully-powered trial.