Sedentary Behavior and Breast Cancer: Interventions and Biomarkers

久坐行为与乳腺癌：干预措施和生物标志物

• 批准号: 9126406
• 负责人: Lisa Anne CadmusBertram
• 金额: $ 13.34万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-09 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9126406
• 关键词: Address; Adopted; Adverse effects; Area; Automobile Driving; Behavior; Behavior Therapy; Behavior assessment; Behavioral; Beryllium; Biological; Biological Markers; Breast Cancer Risk Factor; Breast Cancer survivor; Breast Cancer survivorship; California; Cancer Center; Cancer Control; Cancer Intervention; Cancer Prognosis; Cancer Survivor; Cancer Survivorship; Chronic; Chronic Disease; Communities; Computers; Data; Data Set; Development; Doctor of Philosophy; Educational Background; Elements; Energy Metabolism; Ensure; Environment; Epidemiology; Estrogen Metabolism; Exercise; Faculty; Family Practice; Fatty acid glycerol esters; Fellowship; Fred Hutchinson Cancer Research Center; Funding; Goals; Gonadal Steroid Hormones; Grant; Guidelines; Health; Health behavior; Hormonal; Hour; Individual; Inflammation; Insulin Resistance; Interest Group; Intervention; Intervention Studies; Knowledge; Leadership; Length; Life Style; Link; Malignant Neoplasms; Marshal; Measurement; Measures; Mediating; Mentors; Mentorship; Metabolic; Methods; Obesity; Occupational; Outcome; Overweight; Pathway interactions; Pattern; Physical activity; Pilot Projects; Positioning Attribute; Postmenopause; Preventive Medicine; Psychology; Publications; Publishing; Randomized; Recording of previous events; Research; Research Activity; Research Personnel; Research Project Grants; Research Training; Risk; Role; Students; Testing; Time; Training; Training Activity; United States National Institutes of Health; Universities; Weight; Woman; Writing; anticancer research; biobehavior; breast cancer diagnosis; breast density; cancer biomarkers; cancer prevention; cancer risk; career; career development; case control; circulating biomarkers; design; disorder risk; evidence base; experience; improved; infancy; insight; insulin sensitivity; interest; malignant breast neoplasm; meetings; mid-career faculty; novel; pilot trial; professor; programs; prospective; sedentary; sedentary activity; sedentary lifestyle; skills; statistics; treatment as usual; tv watching; weight loss intervention

DESCRIPTION (provided by applicant): This K07 proposal details a comprehensive program of training activities, mentorship, and research projects that will provide me with the support, knowledge, and skills to launch a career as an independent investigator focused on sedentary behavior and breast cancer. As demonstrated by my educational background, publication history, and research activities, I am dedicated to the field of health behavior, obesity, and cancer prevention and survivorship. I received my Ph.D. in Epidemiology and Psychology from Yale University and completed a postdoctoral fellowship in biobehavioral cancer prevention and control at the Fred Hutchinson Cancer Research Center. I have been conducting research at the Moores Cancer Center at the University of California, San Diego (UCSD) since 2009 and was appointed as Assistant Professor within the UCSD Department of Family and Preventive Medicine in 2013. Completion of this K07 will facilitate my transition to an independent investigator and position me to become a leader in the field of sedentary behavior and cancer. Sedentary behavior, which is physiologically and behaviorally distinct from physical activity, is an emerging area of research that is of growing interest to the cancer community. Research on the adverse health effects of excessive sitting is advancing quickly, with recent data showing that objectively-measured sedentary time is associated with increased breast cancer risk. More research is needed to understand the relationship between sedentary time and breast cancer and to determine whether reducing sedentary time could lower risk and/or improve survival. The proposed training plan will allow me to gain advanced knowledge and skills in: (1) development of sedentary behavior interventions, (2) assessment of sedentary behavior using established & emerging methods, (3) biological mechanisms linking sedentary and active behaviors with cancer, (4) advanced statistics for analysis of sedentary and activity data, and (5) leadership, grant-writing, and career development. UCSD is the ideal environment in which to pursue these goals due to its exceptionally strong group of lifestyle and cancer researchers, the availability o newly-formed interest groups focused on sedentary behavior and health, and the presence of an NCI-funded Transdisciplinary Research on Energetics and Cancer (TREC) Center. My primary mentor will be Dr. Bess Marcus, with co-mentorship provided by Drs. Simon Marshall and Ruth Patterson. Dr. Marcus is Chair of Family and Preventive Medicine at UCSD, has had continuous NIH funding for the past 25 years, and has an excellent track record of mentoring junior faculty. Dr. Marshall is Associate Professor of Family and Preventive Medicine at UCSD, has expertise in sedentary behavior research, and has mentored over 100 students, fellows, and junior faculty. Dr. Patterson is the PI of the UCSD TREC Center and has expertise in cancer biomarkers. Consultants will ensure that I achieve my training and research goals in the areas of sedentary behavior assessment (Dr. Jacqueline Kerr), biologic mechanisms linking sedentary behavior with cancer (Dr. Neville Owen), and advanced statistics (Dr. Loki Natarajan). The proposed research includes 2 distinct, but complementary activities. For Aim 1, I will conduct a pilot study examining interventions to reduce sedentary behavior. Aim 2 uses data from the UCSD TREC Center to examine the association of sedentary behavior with cancer-related biomarkers. Aim 1 (original research): To conduct a 2x2 randomized controlled pilot trial among 60 postmenopausal breast cancer survivors to determine the feasibility of 2 intervention strategies for reducing objectively- measured sedentary behavior. Specifically, I will examine (1) brief "standing breaks" to interrupt long bouts of sedentary time, (2) overall 25% reduction in sedentary time, (3) both in combination, and (4) usual care. Aim 2 (analysis of TREC data): To investigate the potential cancer-relevant benefits of reducing sedentary behavior by examining, among 340 overweight/obese breast cancer survivors, the effects of a behavioral weight loss intervention on sedentary behavior (which is specifically targeted in the intervention). We will also examine whether changes in sedentary behavior mediate the impact of the intervention on biomarker outcomes (i.e. markers of insulin resistance, chronic inflammation, and sex hormones). Aim 1 will enhance my skills in designing and conducting a pilot trial, and study findings will provide insight on reducing sedentary time among breast cancer survivors. Aim 2 will increase my understanding of biomarkers, enhance my statistical and writing skills, and provide novel data on the association of objectively measured sedentary time with cancer-related biomarkers. Taken together, the results of the proposed aims will inform an R01 proposal for a trial examining the efficacy of a sedentary behavior intervention to positively impact circulating biomarkers related to breast cancer prognosis. If funded, this K07 will build on my previous experience in physical activity while taking my career in an exciting new direction focused on sedentary behavior.

描述（由申请人提供）：本K 07提案详细介绍了培训活动，指导和研究项目的综合计划，这些计划将为我提供支持，知识和技能，以开展职业生涯，作为一名专注于久坐行为和乳腺癌的独立调查员。正如我的教育背景，出版历史和研究活动所证明的那样，我致力于健康行为，肥胖和癌症预防和生存领域。我拿到了博士学位。在耶鲁大学流行病学和心理学，并完成了生物行为癌症预防和控制在弗雷德哈钦森癌症研究中心博士后奖学金。自2009年以来，我一直在加州大学圣地亚哥分校（UCSD）的摩尔癌症中心进行研究，并于2013年被任命为UCSD家庭和预防医学系的助理教授。完成这个K 07将有助于我过渡到一个独立的研究者，并使我成为久坐行为和癌症领域的领导者。久坐行为在生理和行为上与身体活动不同，是癌症社区越来越感兴趣的新兴研究领域。关于久坐对健康不利影响的研究正在迅速推进，最近的数据显示，客观测量的久坐时间与乳腺癌风险增加有关。需要更多的研究来了解久坐时间与乳腺癌之间的关系，并确定减少久坐时间是否可以降低风险和/或提高生存率。拟议的培训计划将使我获得先进的知识和技能：（1）久坐行为干预措施的发展，（2）使用既定和新兴方法评估久坐行为，（3）将久坐和活动行为与癌症联系起来的生物学机制，（4）用于分析久坐和活动数据的高级统计数据，以及（5）领导力，赠款写作和职业发展。UCSD是追求这些目标的理想环境，因为它拥有非常强大的生活方式和癌症研究人员群体，新成立的关注久坐行为和健康的兴趣小组，以及NCI资助的能量学和癌症跨学科研究（TREC）中心的存在。我的主要导师将是贝丝·马库斯博士，西蒙·马歇尔博士和露丝·帕特森博士将共同指导我。Marcus博士是UCSD家庭和预防医学的主席，在过去的25年里一直获得NIH的资助，并且在指导初级教师方面有着出色的记录。马歇尔博士是加州大学圣地亚哥分校的家庭和预防医学副教授，在久坐行为研究方面具有专业知识，并指导了100多名学生，研究员和初级教师。Patterson博士是UCSD TREC中心的PI，拥有癌症生物标志物方面的专业知识。顾问将确保我在久坐行为评估（Jacqueline Kerr博士），将久坐行为与癌症联系起来的生物机制（Neville Owen博士）和高级统计学（Loki Natarajan博士）领域实现我的培训和研究目标。拟议的研究包括两个不同但互补的活动。对于目标1，我将进行一项试点研究，检查减少久坐行为的干预措施。目标2使用来自UCSD TREC中心的数据来检查久坐行为与癌症相关生物标志物的关联。目的1（原始研究）：在60名绝经后乳腺癌幸存者中进行2x2随机对照试验，以确定2种干预策略减少客观测量的久坐行为的可行性。具体来说，我将研究（1）短暂的“站立休息”来中断长时间的久坐，（2）久坐时间的总体减少25%，（3）两者结合，（4）日常护理。目的2（TREC数据分析）：通过检查340名超重/肥胖乳腺癌幸存者，研究减少久坐行为的潜在癌症相关益处，行为减肥干预对久坐行为的影响（这是干预中专门针对的）。我们还将研究久坐行为的变化是否介导了干预对生物标志物结果（即胰岛素抵抗，慢性炎症和性激素的标志物）的影响。目标1将提高我设计和进行试点试验的技能，研究结果将为减少乳腺癌幸存者的久坐时间提供见解。目标2将增加我对生物标志物的理解，提高我的统计和写作技能，并提供关于客观测量的久坐时间与癌症相关生物标志物之间关系的新数据。总的来说，拟议目标的结果将为R 01的一项试验提案提供信息，该试验旨在检查久坐行为干预对与乳腺癌预后相关的循环生物标志物产生积极影响的有效性。如果获得资助，K 07将建立在 我以前的体育锻炼经验，同时把我的职业生涯在一个令人兴奋的新方向集中在久坐不动的行为。