Tissue Procurement Shared Facility

组织采购共享设施

• 批准号: 9895653
• 负责人: UPENDER MANNE
• 金额: $ 18.71万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9895653
• 关键词: Accreditation; Advisory Committees; Advocacy; Advocate; African American; American; Area; Autopsy; Basic Science; Benign; Biological; Cancer Center; Catchment Area; Clinical Data; Clinical Pathology; Clinical Protocols; Clinical Research; Clinical Trials; Collaborations; Collection; Communication; Complex; Comprehensive Cancer Center; Computerized Medical Record; Consultations; Custom; Cytopathology; Data; Development; Disease; Education; Education and Outreach; Educational workshop; Ensure; Environment; Equipment; Experimental Designs; Financial Support; Freezing; Funding; Gap Junctions; Goals; Grant; Histology; Human; Human Resources; Individual; Informatics; Information Technology; Institution; International; Leadership; Liquid substance; Methodology; Minority; Mission; Monitor; Online Systems; Operative Surgical Procedures; Paraffin; Pathologic; Pathologist; Pathology; Patients; Physician Assistants; Play; Practice Guidelines; Preparation; Procedures; Process; Productivity; Protocols documentation; Publications; Race; Reporting; Research; Research Personnel; Research Support; Resources; Role; Science; Secure; Services; Slide; Societies; Solid; Source; Specialist; Specimen; Standardization; Strategic Planning; Surgical Pathology; System; Time; Tissue Banks; Tissue Procurements; Tissue Sample; Tissues; Translational Research; Tumor Biology; United States National Institutes of Health; University of Alabama at Birmingham Cancer Center; Update; Work; anticancer research; base; biobank; cancer therapy; college; cost; cost effective; cost effectiveness; diagnostic accuracy; human tissue; improved; member; neoplastic; new technology; novel; operation; outreach program; programs; recruit; repository; sample collection; tissue processing; translational study

CLINICAL RESEARCH GROUP TISSUE PROCUREMENT SHARED FACILITY (TPSF) ABSTRACT The goal of the UAB Comprehensive Cancer Center Tissue Procurement Shared Facility (TPSF) is to promote the research undertaken by UAB-CCC investigators by ensuring the availability of relevant, high quality human tissues. The TPSF accomplishes this through the collection, processing, storage, and distribution of a wide range of human tissues. Neoplastic and control tissues are supplied as fresh, frozen, paraffin-processed specimens or tissue sections. Bodily fluids and fluid components also can be provided. Pathologists evaluate all solid tissues supplied for research for quality and diagnostic accuracy. The supplementary services provided, including specialized histology, macrodissection and customized clinical data, are of demonstrable significance to the UAB-CCC investigators as are the ability of the TPSF to work effectively with other UAB- CCC Shared Facilities and affiliates. The TPSF leadership provides expert individual guidance to the UAB- CCC investigators in experimental design and the effective use of emerging methodologies in basic and translational research, as well as ensuring compliance in the changing regulatory environment. The leadership's expertise is based on active research in the area of tissue processing and banking as well as their participation in educational and outreach programs at the local, national and international levels. Strategic planning has been used to harness institutional and philanthropic resources to expand the capabilities of the Facility while improving the cost-effectiveness of its operations. Initiatives that have been undertaken since 2011 include extensive renovations, updating of equipment and harmonization of standard-operating- procedures for accreditation by the College of American Pathologists; continued improvements in information technology applications that will enhance research capabilities while reducing labor costs; and establishment of the CCC Tissue Bank. Institutional support has permitted targeted recruitment of an additional pathologist, an informatics specialist, and a pathology physician's assistant to aid the TPSF. The TPSF serves investigators in all six UAB-CCC programs and since 2011 its involvement in clinical trials has tripled. It plays a central role in promoting the mission of the Cancer Center in terms of providing tissues from African-American patients that support their inclusion in early translational studies. From March 2011 to March 2015 the TPSF has supported requests from 57 UAB-CCC investigators and has supported 32 clinical trials. Between January and December 2014 the facility provided 38 UAB-CCC investigators with 919 fresh or frozen human tissue samples, 754 paraffin blocks, and 12,925 slides. TPSF-supported research has been reported in over 120 publications during this time period. Since 1978, the facility has provided approximately 212,000 tissue specimens, blocks, and slides to investigators at UAB. These have been used in a total of 1,295 publications.

临床研究组 组织采购共享设施 (TPSF) 抽象的 UAB 综合癌症中心组织采购共享设施 (TPSF) 的目标是促进 UAB-CCC 研究人员通过确保相关的、高质量的人类资源的可用性来进行研究 组织。 TPSF 通过收集、处理、存储和分发广泛的信息来实现这一目标 人体组织范围。肿瘤组织和对照组织以新鲜、冷冻、石蜡加工的形式提供 标本或组织切片。还可以提供体液和流体成分。病理学家评估 所有实体组织均提供用于研究，以确保质量和诊断准确性。补充服务 提供的，包括专门的组织学、宏观解剖和定制的临床数据，是可证明的 TPSF 与其他 UAB-CCC 调查人员有效合作的能力对 UAB-CCC 调查人员具有重要意义。 CCC 共享设施和附属机构。 TPSF 领导层为 UAB 提供专家个人指导 CCC 研究人员在实验设计和有效使用新兴方法论方面进行基础和研究 转化研究，以及确保不断变化的监管环境中的合规性。这 领导层的专业知识基于组织加工和银行领域的积极研究及其 参与地方、国家和国际各级的教育和外展计划。战略 规划已被用来利用机构和慈善资源来扩大机构的能力 设施，同时提高其运营的成本效益。自此以来采取的举措 2011 年包括大规模翻新、设备更新以及标准操作的协调 美国病理学家学会的认证程序；信息化持续改进 技术应用将增强研究能力，同时降低劳动力成本；并设立 CCC 组织库。机构支持允许有针对性地招募一名额外的病理学家，一名 信息学专家和协助 TPSF 的病理医师助理。 TPSF 为调查人员提供服务 全部六个 UAB-CCC 项目，自 2011 年以来，其临床试验参与度增加了两倍。它发挥着核心作用 促进癌症中心的使命，即提供非裔美国患者的组织， 支持将其纳入早期转化研究。从2011年3月到2015年3月，TPSF支持了 来自 57 名 UAB-CCC 研究人员的请求，并支持了 32 项临床试验。一月至 2014 年 12 月，该机构向 38 名 UAB-CCC 研究人员提供了 919 份新鲜或冷冻人体组织 样品、754 个石蜡块和 12,925 个载玻片。 TPSF 支持的研究已在 120 多项中得到报道 这段时间的出版物。自 1978 年以来，该设施已提供约 212,000 张纸巾 向 UAB 的研究人员提供标本、块和载玻片。这些已在总共 1,295 种出版物中使用。