Repeated-dose behavioral intervention to reduce opioid overdose: a two-site randomized-controlled efficacy trial
Repeated-dose behavioral intervention to reduce opioid overdose: a two-site randomized-controlled efficacy trial
批准号:
9896799
负责人:
PHILLIP O COFFIN
金额:
$83.16万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-06-15 至 2023-03-31
关键词:
AddressAdultAffectAlcohol or Other Drugs useBehavior TherapyBehavioralBostonCessation of lifeClientComputer AssistedCounselingCountryCox Proportional Hazards ModelsDataDoseDrug usageEducationEducational CurriculumEffectivenessEmergency SituationEnrollmentEnsureEpidemicEventFentanylFundingFutureGenerationsHealthHeroinHome environmentIndividualInterventionInterviewKnowledgeMedicalMedical RecordsModelingMotivationNaloxoneNational Institute of Drug AbuseNew EnglandOpiate AddictionOpioidOpioid AnalgesicsOverdoseParticipantPatientsPersonsPharmaceutical PreparationsPilot ProjectsPoisoningPopulationPopulation InterventionPrinted MediaProcessRandomizedRandomized Controlled TrialsRecommendationRecruitment ActivityRecurrenceReportingResourcesRiskRisk BehaviorsRisk FactorsSan FranciscoSiteSubstance Use DisorderSyringesTestingTimeTrainingUnited StatesValidationVisitattentional controlauthoritybasebehavior changebrief interventioncomparative efficacydrug use behaviorefficacy trialexperiencefollow-uphigh riskillicit opioidmathematical modelmortalitymotivational enhancement therapyopioid epidemicopioid mortalityopioid overdoseopioid useopioid use disorderopioid useroverdose preventionoverdose riskpreventprogramsrandomized trialreduced substance usescreeningservice programsskillssocial mediasocial stigmasynthetic opioidtreatment as usualtreatment servicestrendwillingness
中文摘要
项目总结/摘要
美国正处于阿片类药物过量的流行之中,包括阿片类镇痛药,海洛因和其他药物。
制造芬太尼和相关的合成阿片类药物。解决阿片类药物过量的多种干预措施
被雇用,如奠定获得纳洛酮,以扭转阿片类药物过量,但死亡人数
每年因阿片类药物过量而死亡的人数每年都在增加。除了努力降低死亡率外,
需要努力减少任何阿片类药物过量的发生,特别是考虑到合成阿片类药物的快速性,
阿片类药物过量,这可能会限制一旦发生过量干预的时间。阿片
为避免又一代人受到阿片类药物流行病的影响而必须开展的管理活动,
自相矛盾地助长了非法阿片类药物的流行,并扩大了获得阿片类药物使用障碍治疗的机会,
虽然是必要的,但受到资源、耻辱和患者接受干预的意愿的限制。的
NIDA资助的REBOOT(减少阿片类药物过量的重复剂量行为干预)试点研究,
基于动机访谈的简短干预,解决经历和目睹的过量事件,
导致任何阿片类药物过量的发生率以及阿片类药物的数量大幅减少,
16个月随访期间发生的药物过量。REBOOT的完整试验包括两个区域,
美国-弗朗西斯科,基本上不受芬太尼流行的影响-和波士顿,在震中
芬太尼的使用过量和死亡率REBOOT将招募300名患有阿片类药物使用障碍的患者,
目前使用阿片类药物,以前接受过纳洛酮带回家,并且复发风险高
服药过量参与者将被随机分配到干预组或注意力控制组,每四个月观察一次
持续16个月,定期评估药物过量事件、药物过量风险因素、药物参与
使用障碍治疗和物质使用。将审查医疗记录,以记录未报告的药物过量
事件,包括死亡。结果将确定通过动机性访谈解决过量是否可以
减少用药过量的发生,为应对这一国家紧急情况的努力作出贡献。
英文摘要
Project Summary/Abstract
The United States is amidst an epidemic of opioid overdose, including opioid analgesics, heroin, and illicitly-
manufactured fentanyl and related synthetic opioids. Multiple interventions to address opioid overdose have
been employed, such as lay access to naloxone to reverse opioid overdose, yet the number of people dying
each year from opioid overdose continues to increase each year. In addition to efforts to reduce mortality,
efforts are needed to reduce the occurrence of any opioid overdose, particularly given the rapidity of synthetic
opioid overdoses, which may restrict the time available to intervene once an overdose occurs. Opioid
stewardship activities, necessary to avert yet another generation affected by the opioid epidemic, may
paradoxically contribute to the illicit opioid epidemic, and expanded access to opioid use disorder treatment,
while essential, is limited by resources, stigma, and the willingness of patients to accept the intervention. The
NIDA-funded pilot study of REBOOT (repeated dose behavioral intervention to reduce opioid overdose), a
motivational interviewing-based brief intervention addressing experienced and witnessed overdose events,
resulted in substantial reductions in the occurrence of any opioid overdose, as well as the number of opioid
overdoses that occurred during 16 months of follow-up. This full trial of REBOOT includes two regions of the
United States – San Francisco, largely unaffected by the fentanyl epidemic – and Boston, at the epicenter of
fentanyl use, overdose, and mortality. REBOOT will enroll 300 persons with opioid use disorder who are
currently using opioids, have previously received take-home naloxone, and are at high-risk for recurrent
overdose. Participants will be randomized to the intervention or attention-control and seen every four months
for 16 months, with interval assessments for overdose events, overdose risk factors, engagement in substance
use disorder treatment, and substance use. Medical records will be reviewed to capture unreported overdose
events, including death. Results will determine if addressing overdose through motivational interviewing can
reduce the occurrence of overdose, contributing to efforts to respond to this national emergency.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
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