Mid-Career Award in Patient-Oriented Substance Use Research Addressing Opioids, Chronic Pain, and HIV

针对阿片类药物、慢性疼痛和艾滋病毒的以患者为导向的药物使用研究中的职业生涯中期奖

• 批准号: 9981708
• 负责人: PHILLIP O COFFIN
• 金额: $ 15.13万
• 依托单位: SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9981708
• 关键词: Address; Adoption; Affect; Agreement; Alcohol or Other Drugs use; American; Attention; Award; Behavior; Behavior Therapy; Biometry; Blood; Board Certification; Caring; Clinic; Clinical; Clinical Trials; Cognitive; Consensus; Counseling; Data; Development; Doctor shopping; Educational Status; Ensure; Epidemic; Equation; Equilibrium; Event; Foundations; Frequencies; Funding; Future; Goals; HIV; HIV Seronegativity; HIV Seropositivity; Healthcare Systems; Hepatitis C Therapy; Intervention; Lead; Leadership; Logistic Regressions; Medical; Medicine; Mentors; Mid-Career Clinical Scientist Award (K24); Mirtazapine; Modeling; Naloxone; Naltrexone; Non-Malignant; Opioid; Outcome; Overdose; Pain; Pain Research; Pain management; Palliative Care; Patient Care; Patients; Pattern; Peripheral Nervous System Diseases; Pharmaceutical Preparations; Pharmacology; Poisoning; Policies; Primary Health Care; Provider; Reading; Research; Research Design; Research Personnel; Risk; Schedule; Societies; Specialist; Structure; Substance Use Disorder; System; Testing; Time; Toxicology; Training; United States Department of Veterans Affairs; Urine; Viral; Visit; Work; addiction; aripiprazole; base; career; chronic pain; chronic pain management; clinical care; comorbidity; experience; illicit opioid; improved; mortality; motivational enhancement therapy; non-opioid analgesic; opioid overdose; opioid therapy; opioid use; patient oriented; prescription opioid; programs; prospective; reduced substance use; safety net; stimulant use; transmission process; treatment trial; uptake; viral transmission

Project Abstract This K24 award will support the candidate’s development as a mentor and substance use researcher, while completing a study the impact of reduced or discontinued opioid therapy on patients infected with HIV. The candidate will complete advanced training in mentoring and meet regularly with senior mentors to improve his mentoring, while increasing his mentoring load throughout the award period. He will also enhance his ability to excel as a substance use researcher addressing opioid use and chronic pain by completing American Board of Addiction Medicine board certification and the American Pain Society Fundamentals of Pain Medicine course, completing independent structured reading programs addressing pain research as well as biostatistics and research design, and gaining direct clinical experience in chronic pain management. In addition, the candidate will pursue new research to examine the impact of discontinuation of prescription opioid use among HIV- positive patients. The candidate will perform extensive chart extraction research on 600 patients prescribed opioids for chronic pain (300 HIV-positive, 300 frequency-matched HIV-negative) in years 1-2 and 3-4 of the award period in order to characterize the trajectory of opioid prescribing and rationale for continuation or changes in opioid therapy, compare opioid prescribing patterns and yellow flag behaviors among HIV-positive and HIV-negative patients, and prospectively assess the relationship between receipt of prescription opioids and clinic care of HIV-positive and HIV-negative patients. Analysis will involve pooled logistic regression modeling adjusted for frequency-matching strata, and generalized estimating equations, depending on the hypothesis being tested.

项目摘要 该 K24 奖项将支持候选人作为导师和药物使用研究员的发展，同时 完成一项研究，了解减少或停止阿片类药物治疗对艾滋病毒感染者的影响。这 候选人将完成指导方面的高级培训，并定期与高级导师会面，以提高他的水平 指导，同时在整个奖励期间增加他的指导负担。他还将增强自己的能力 通过完成美国委员会的研究，成为解决阿片类药物使用和慢性疼痛问题的物质使用研究人员 成瘾医学委员会认证和美国疼痛协会疼痛医学基础课程， 完成独立的结构化阅读计划，涉及疼痛研究以及生物统计学和 研究设计，并获得慢性疼痛管理的直接临床经验。此外，候选人 将开展新的研究，以检验停止使用处方阿片类药物对艾滋病毒感染者的影响 阳性患者。候选人将对 600 名处方患者进行广泛的图表提取研究 在第 1-2 年和第 3-4 年使用阿片类药物治疗慢性疼痛（300 例 HIV 阳性，300 例频率匹配的 HIV 阴性） 授予期，以描述阿片类药物处方的轨迹以及继续或继续使用的理由 阿片类药物治疗的变化，比较艾滋病毒阳性者的阿片类药物处方模式和黄旗行为 和 HIV 阴性患者，并前瞻性评估接受处方阿片类药物之间的关系 以及艾滋病毒阳性和艾滋病毒阴性患者的临床护理。分析将涉及汇总逻辑回归 针对频率匹配地层和广义估计方程进行调整的建模，具体取决于 假设正在被检验。