Mid-Career Award in Patient-Oriented Substance Use Research Addressing Opioids, Chronic Pain, and HIV

针对阿片类药物、慢性疼痛和艾滋病毒的以患者为导向的药物使用研究中的职业生涯中期奖

• 批准号: 9981708
• 负责人: PHILLIP O COFFIN
• 金额: $ 15.13万
• 依托单位: SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9981708
• 关键词: Address; Adoption; Affect; Agreement; Alcohol or Other Drugs use; American; Attention; Award; Behavior; Behavior Therapy; Biometry; Blood; Board Certification; Caring; Clinic; Clinical; Clinical Trials; Cognitive; Consensus; Counseling; Data; Development; Doctor shopping; Educational Status; Ensure; Epidemic; Equation; Equilibrium; Event; Foundations; Frequencies; Funding; Future; Goals; HIV; HIV Seronegativity; HIV Seropositivity; Healthcare Systems; Hepatitis C Therapy; Intervention; Lead; Leadership; Logistic Regressions; Medical; Medicine; Mentors; Mid-Career Clinical Scientist Award (K24); Mirtazapine; Modeling; Naloxone; Naltrexone; Non-Malignant; Opioid; Outcome; Overdose; Pain; Pain Research; Pain management; Palliative Care; Patient Care; Patients; Pattern; Peripheral Nervous System Diseases; Pharmaceutical Preparations; Pharmacology; Poisoning; Policies; Primary Health Care; Provider; Reading; Research; Research Design; Research Personnel; Risk; Schedule; Societies; Specialist; Structure; Substance Use Disorder; System; Testing; Time; Toxicology; Training; United States Department of Veterans Affairs; Urine; Viral; Visit; Work; addiction; aripiprazole; base; career; chronic pain; chronic pain management; clinical care; comorbidity; experience; illicit opioid; improved; mortality; motivational enhancement therapy; non-opioid analgesic; opioid overdose; opioid therapy; opioid use; patient oriented; prescription opioid; programs; prospective; reduced substance use; safety net; stimulant use; transmission process; treatment trial; uptake; viral transmission

Project Abstract This K24 award will support the candidate’s development as a mentor and substance use researcher, while completing a study the impact of reduced or discontinued opioid therapy on patients infected with HIV. The candidate will complete advanced training in mentoring and meet regularly with senior mentors to improve his mentoring, while increasing his mentoring load throughout the award period. He will also enhance his ability to excel as a substance use researcher addressing opioid use and chronic pain by completing American Board of Addiction Medicine board certification and the American Pain Society Fundamentals of Pain Medicine course, completing independent structured reading programs addressing pain research as well as biostatistics and research design, and gaining direct clinical experience in chronic pain management. In addition, the candidate will pursue new research to examine the impact of discontinuation of prescription opioid use among HIV- positive patients. The candidate will perform extensive chart extraction research on 600 patients prescribed opioids for chronic pain (300 HIV-positive, 300 frequency-matched HIV-negative) in years 1-2 and 3-4 of the award period in order to characterize the trajectory of opioid prescribing and rationale for continuation or changes in opioid therapy, compare opioid prescribing patterns and yellow flag behaviors among HIV-positive and HIV-negative patients, and prospectively assess the relationship between receipt of prescription opioids and clinic care of HIV-positive and HIV-negative patients. Analysis will involve pooled logistic regression modeling adjusted for frequency-matching strata, and generalized estimating equations, depending on the hypothesis being tested.

项目摘要