Midcareer K24 Award for Mentoring and Patient-Oriented Research

项目总结/摘要 这个K24奖项将支持候选人作为导师和物质使用调查员的发展， 完成一项关于使用非处方兴奋剂进行慢性疼痛自我护理的新研究，特别是 艾滋病病毒感染者和神经性疼痛患者中。候选人将通过以下方式完成指导培训： 差异，以进一步提高他的能力，指导学员在科学中代表不足，同时也 制定和提供针对非代表性不足的导师的培训， 能够有效指导代表性不足的学员的高级导师管道。他还将加强他的 通过获得实施科学方面的额外培训进行物质使用研究的能力， 生态瞬时评估、适应性试验设计和疼痛研究。他将进行指导性阅读 与疼痛研究和指导方面的专家一起工作。此外，候选人将继续进行新的研究， 使用非处方兴奋剂的现象慢性疼痛的自我护理。候选人将招收50人 报告使用甲基苯丙胺进行疼痛自我护理6个月的HIV和神经性疼痛患者 生态瞬时评估，以确定使用和功能性疼痛之间的关系。的 候选人将与30名参与者进行定性访谈，以探索疼痛的性质， 身体和社会痛苦之间的关系，以及对甲基苯丙胺的风险和益处的认识 使用.最后，他将比较那些不使用兴奋剂，谁使用兴奋剂的疼痛，谁使用 从他对慢性疼痛患者的纵向队列研究中， 甲基苯丙胺用于疼痛自我护理的纵向效应。

Project Summary/Abstract This K24 award will support the candidate’s development as a mentor and substance use investigator, while completing a novel study of the use of non-prescribed stimulants in the self-care of chronic pain, particularly among people living with HIV and neuropathic pain. The candidate will complete training in mentoring through differentness to further enhance his ability to mentor trainees underrepresented in science, while also developing and delivering a training targeted for mentors not underrepresented, in order to improve the pipeline of senior mentors who can effectively mentor underrepresented trainees. He will also enhance his abilities to conduct substance use research by obtaining additional training in implementation science, ecological momentary assessment, adaptive trial design, and pain research. He will undertake directed reading with experts in pain research and in mentoring. In addition, the candidate will pursue new research to examine the phenomenon of non-prescribed stimulant use self-care of chronic pain. The candidate will enroll 50 people living with HIV and neuropathic pain who report methamphetamine use for pain self-care for 6 months of ecological momentary assessments, to determine the relationship between use and functional pain. The candidate will conduct qualitative interviews with 30 of the participants to explore the nature of the pain and relationship between physical and social pain, as well as the perceived risks and benefits to methamphetamine use. Finally, he will compare those who do not use stimulants, who use stimulants for pain, and who use stimulants for other reasons from his longitudinal cohort study of patients with chronic pain to establish longitudinal effects of methamphetamine use for pain self-care.