Midcareer K24 Award for Mentoring and Patient-Oriented Research

项目摘要/摘要 这个K24奖项将支持候选人作为导师和药物使用调查员的发展，同时 完成一项关于非处方兴奋剂在慢性疼痛自我护理中的使用的新研究，特别是 在艾滋病毒携带者和神经病理性疼痛的患者中。候选人将通过以下方式完成指导方面的培训 与众不同，以进一步增强他指导科学方面代表性不足的受训人员的能力，同时还 为没有任职人数不足的导师制定和提供有针对性的培训，以改善 高级导师的渠道，他们可以有效地指导代表不足的实习生。他还将加强他的 通过获得实施科学方面的额外培训来进行物质使用研究的能力， 生态瞬时评估、适应性试验设计和疼痛研究。他将进行定向阅读 与疼痛研究和指导方面的专家合作。此外，候选人将继续进行新的研究以审查 非处方兴奋剂使用慢性疼痛的自理现象。这位候选人将招收50人 艾滋病毒携带者和神经病理性疼痛患者报告6个月来使用甲基苯丙胺进行疼痛自我护理 生态瞬间评估，以确定使用和功能性疼痛之间的关系。这个 候选人将对其中30名参与者进行定性访谈，以探索疼痛的性质和 身体和社会痛苦之间的关系，以及甲基苯丙胺的风险和益处 使用。最后，他将比较不使用兴奋剂的人、使用兴奋剂止痛的人和使用兴奋剂的人 其他原因的兴奋剂从他对慢性疼痛患者的纵向队列研究中建立 甲基苯丙胺用于疼痛自我护理的纵向效应。

Project Summary/Abstract This K24 award will support the candidate’s development as a mentor and substance use investigator, while completing a novel study of the use of non-prescribed stimulants in the self-care of chronic pain, particularly among people living with HIV and neuropathic pain. The candidate will complete training in mentoring through differentness to further enhance his ability to mentor trainees underrepresented in science, while also developing and delivering a training targeted for mentors not underrepresented, in order to improve the pipeline of senior mentors who can effectively mentor underrepresented trainees. He will also enhance his abilities to conduct substance use research by obtaining additional training in implementation science, ecological momentary assessment, adaptive trial design, and pain research. He will undertake directed reading with experts in pain research and in mentoring. In addition, the candidate will pursue new research to examine the phenomenon of non-prescribed stimulant use self-care of chronic pain. The candidate will enroll 50 people living with HIV and neuropathic pain who report methamphetamine use for pain self-care for 6 months of ecological momentary assessments, to determine the relationship between use and functional pain. The candidate will conduct qualitative interviews with 30 of the participants to explore the nature of the pain and relationship between physical and social pain, as well as the perceived risks and benefits to methamphetamine use. Finally, he will compare those who do not use stimulants, who use stimulants for pain, and who use stimulants for other reasons from his longitudinal cohort study of patients with chronic pain to establish longitudinal effects of methamphetamine use for pain self-care.