Sensorimotor impairments in men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome: relationship of resting state brain activity to pelvic floor muscle activation

慢性前列腺炎/慢性盆腔疼痛综合征男性的感觉运动障碍:静息状态大脑活动与盆底肌肉激活的关系

基本信息

  • 批准号:
    9896815
  • 负责人:
  • 金额:
    $ 33.23万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-02-01 至 2022-10-31
  • 项目状态:
    已结题

项目摘要

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common and often debilitating condition. The underlying cause of CP/CPPS remains unknown. We recently published the first neuroimaging study comparing men with CP/CPPS to healthy men. We found that, most importantly, the functional connectivity between a brain motor region that activates pelvic floor muscles and a viscerosensory region in the right posterior insula was significantly reduced in men with CP/CPPS compared to healthy men. This prior work suggests that understanding this sensorimotor functional connection, which we term pelvic-motor/right- posterior-insula functional connectivity, may be critical to understanding the pathophysiology of CP/CPPS. However, we still do not fundamentally know how resting brain function influences active sensorimotor control. In the proposed work, we aim to fill this knowledge gap by relating pelvic-motor/right-posterior-insula functional connectivity to automatic pelvic floor muscle activation during voluntary activation of non-pelvic floor muscles in men with and without CP/CPPS. We will recruit 52 men with CP/CPPS and 52 healthy men. In each participant, we will use resting-state functional Magnetic Resonance Imaging (rs-fMRI) to quantify pelvic-motor/right- posterior-insula functional connectivity, surface EMG to quantify automatic pelvic floor muscle activation during voluntary gluteal muscle activation, and questionnaires to quantify CP/CPPS pain intensity. rs-fMRI, EMG, and pain measures will be analyzed with the following Aims. In Aim 1, we will study inter-individual differences in men and determine if reduced pelvic-motor/right-posterior-insula functional connectivity correlates with increases in the magnitude of automatic pelvic floor muscle activation during voluntary activation of non-pelvic floor muscles. In Aim 2, we will compare healthy men and men with CP/CPPS, whom we have shown to have a reduced value of resting state pelvic-motor/right-posterior-insula functional connectivity compared to healthy male controls. We will determine if men with CP/CPPS show corresponding increases in the magnitude of automatic pelvic floor muscle activation during voluntary activation of the gluteus maximus muscle, and if the magnitude of automatic pelvic floor muscle activation is correlated with the intensity of CP/CPPS pain. This work, to our knowledge, represents the first study relating resting brain function to the magnitude of automatic muscle activation during movement. This work is also the first study proposing to test a specific mechanism of altered pelvic floor muscle control in men with CP/CPPS. Our prior work defined a brain connection of interest in men with CP/CPPS. Our proposed work will determine if this brain connection is related to altered movement control. Our future work will be able to then examine modifying movement control as an approach to restoring normal brain function in men with CP/CPPS.
慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)是一种常见且常使人衰弱的疾病。的

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Distributed representation of pelvic floor muscles in human motor cortex.
  • DOI:
    10.1038/s41598-018-25705-0
  • 发表时间:
    2018-05-08
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Yani MS;Wondolowski JH;Eckel SP;Kulig K;Fisher BE;Gordon JE;Kutch JJ
  • 通讯作者:
    Kutch JJ
Salience network functional connectivity is spatially heterogeneous across sensorimotor cortex in healthy humans.
  • DOI:
    10.1016/j.neuroimage.2020.117177
  • 发表时间:
    2020-11-01
  • 期刊:
  • 影响因子:
    5.7
  • 作者:
    Hegarty AK;Yani MS;Albishi A;Michener LA;Kutch JJ
  • 通讯作者:
    Kutch JJ
Motor cortical neuromodulation of pelvic floor muscle tone: Potential implications for the treatment of urologic conditions.
盆底肌张力的运动皮质神经调节:对泌尿系统疾病治疗的潜在影响。
  • DOI:
    10.1002/nau.24014
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    2
  • 作者:
    Yani,MohebS;Fenske,SonjaJ;Rodriguez,LarissaV;Kutch,JasonJ
  • 通讯作者:
    Kutch,JasonJ
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Jason J. Kutch其他文献

Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network
泌尿外科慢性骨盆疼痛综合征:来自 MAPP 研究网络的见解
  • DOI:
    10.1038/s41585-018-0135-5
  • 发表时间:
    2018-12-18
  • 期刊:
  • 影响因子:
    14.600
  • 作者:
    J. Quentin Clemens;Chris Mullins;A. Lenore Ackerman;Tamara Bavendam;Adrie van Bokhoven;Benjamin M. Ellingson;Steven E. Harte;Jason J. Kutch;H. Henry Lai;Katherine T. Martucci;Robert Moldwin;Bruce D. Naliboff;Michel A. Pontari;Siobhan Sutcliffe;J. Richard Landis
  • 通讯作者:
    J. Richard Landis

Jason J. Kutch的其他文献

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{{ truncateString('Jason J. Kutch', 18)}}的其他基金

Motor cortical neuromodulation in women with Interstitial Cystitis/Bladder Pain Syndrome: reducing pain by improving brain and muscle activity
患有间质性膀胱炎/膀胱疼痛综合征的女性的运动皮质神经调节:通过改善大脑和肌肉活动来减轻疼痛
  • 批准号:
    10655675
  • 财政年份:
    2020
  • 资助金额:
    $ 33.23万
  • 项目类别:
Motor cortical neuromodulation in women with Interstitial Cystitis/Bladder Pain Syndrome: reducing pain by improving brain and muscle activity
患有间质性膀胱炎/膀胱疼痛综合征的女性的运动皮质神经调节:通过改善大脑和肌肉活动来减轻疼痛
  • 批准号:
    10630071
  • 财政年份:
    2020
  • 资助金额:
    $ 33.23万
  • 项目类别:
Motor cortical neuromodulation in women with Interstitial Cystitis/Bladder Pain Syndrome: reducing pain by improving brain and muscle activity
患有间质性膀胱炎/膀胱疼痛综合征的女性的运动皮质神经调节:通过改善大脑和肌肉活动来减轻疼痛
  • 批准号:
    10400904
  • 财政年份:
    2020
  • 资助金额:
    $ 33.23万
  • 项目类别:
Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Discovery Site
慢性盆腔疼痛 (MAPP) 研究网络发现网站的多学科方法
  • 批准号:
    10206104
  • 财政年份:
    2008
  • 资助金额:
    $ 33.23万
  • 项目类别:
Neuromechanics of Differential Motor Unit Activation in Multifunctional Muscles
多功能肌肉差动运动单位激活的神经力学
  • 批准号:
    7220736
  • 财政年份:
    2007
  • 资助金额:
    $ 33.23万
  • 项目类别:
Neuromechanics of Differential Motor Unit Activation in Multifunctional Muscles
多功能肌肉差动运动单位激活的神经力学
  • 批准号:
    7352765
  • 财政年份:
    2007
  • 资助金额:
    $ 33.23万
  • 项目类别:

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