Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Discovery Site

慢性盆腔疼痛 (MAPP) 研究网络发现网站的多学科方法

• 批准号: 10206104
• 负责人: Jason J. Kutch
• 金额: $ 15.82万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10206104
• 关键词: Biological; Chronic; Chronic Fatigue Syndrome; Chronic Prostatitis; Clinical; Clinical Research; Clinical Trials Design; Data; Data Analyses; Enrollment; Epidemiology; Etiology; Event; Fibromyalgia; Funding; Goals; Individual; Interstitial Cystitis; Iowa; Irritable Bowel Syndrome; Manuscripts; Measurement; Measures; Michigan; National Institute of Diabetes and Digestive and Kidney Diseases; Natural History; Pain; Pain Disorder; Participant; Pattern; Persons; Phase; Phenotype; Physiological; Preparation; Protocols documentation; Public Health; Research; Research Personnel; Risk Factors; Site; Symptoms; System; Time; Universities; Washington; Woman; chronic painful condition; chronic pelvic pain; clinically relevant; design; epidemiologic data; follow-up; improved; insight; interdisciplinary approach; men; participant enrollment; patient subsets; recruit; response; symptom management; treatment response; trend; urologic; urologic chronic pelvic pain syndrome

ABSTRACT Urologic Chronic Pelvic Pain Syndrome (UCPPS) encompasses two highly prevalent chronic urologic pain disorders, interstitial cystitis/ bladder pain syndrome (IC/BPS) in men and women, and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men. Like many chronic pain disorders, UCPPS is poorly understood and characterized, and treatment is mostly empirical and unsatisfactory. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network was established by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), to study the etiology and treated natural history of UCPPS, to inform better treatments and management of symptoms through improved designs of clinical trials, and to identify clinical factors and research measurements to define clinically relevant sub-groups of these patients. The MAPP Research Network is currently completing enrollment of participants into the Trans-MAPP Symptom Patterns Study (SPS), which involves integrated phenotyping of UCPPS participants at baseline and during a 36-month longitudinal, observational period. The SPS includes measures to refine UCPPS subgrouping, identify symptom trends, and discover associated risk factors and biological correlates to progression profiles. Integrated within the central protocol are studies to correlate clinical and biological profiles with response to selected UCPPS therapies (the Analysis of Therapies during Longitudinal Assessment of Symptoms [ATLAS] study). The current funding period ends in June 2019. We propose a three-year funding extension, through June 2022. During the proposed three-year extension, we aim to accomplish the following: SPECIFIC AIM 1: To Obtain an Additional 12 Months of Follow-up in the MAPP- II SPS. The MAPP-II SPS was designed to follow UCPPS participants for up to three years. By extending the timeframe for longitudinal follow-up from July 2019 to July 2020, the number of UCPPS participants followed for three years in the SPS will almost double (from 198 to 384). This additional data will substantially increase the ability of MAPP investigators to examine patterns and predictors of UCPPS symptoms over time. SPECIFIC AIM 2: To Observe Additional ATLAS Events in the MAPP-II SPS. A major focus of the MAPP-II SPS is to correlate individual participant phenotypes with UCPPS treatment response. To accomplish this, SPS participants complete a phenotyping assessment before and after starting new UCPPS treatments (ATLAS study). The additional year of follow-up will provide time for new treatment `events' to occur which can be included in this important analysis. SPECIFIC AIM 3: To Conduct Analyses of MAPP-II Data. The current funding period provides inadequate time for MAPP investigators to analyze the data collected as part of the SPS. Therefore, the final two years of the proposed three-year MAPP-II extension will be devoted exclusively to data analysis and manuscript preparation.

摘要 泌尿系慢性盆腔疼痛综合征（UCPPS）包括两种高度流行的慢性泌尿系疼痛 男性和女性的间质性膀胱炎/膀胱疼痛综合征（IC/BPS）以及慢性 前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）。像许多慢性疼痛疾病一样，UCPPS是 对这些疾病的认识和特点知之甚少，治疗大多是经验性的，不能令人满意。的 多学科方法研究慢性盆腔疼痛（MAPP）研究网络是由 国家糖尿病、消化和肾脏疾病研究所（NIDDK），研究病因， 治疗UCPPS的自然史，通过改善症状的治疗和管理， 临床试验的设计，并确定临床因素和研究测量，以确定临床相关 这些患者的亚组。MAPP研究网络目前正在完成参与者的登记 trans-MAPP症状模式研究（SPS），其中包括UCPPS的综合表型 在基线和36个月的纵向观察期内的参与者。《卫生和植物检疫措施》包括 完善UCPPS亚组，确定症状趋势，并发现相关的风险因素和生物学 与进展情况相关。在中心方案中整合了将临床和 对选定的UCPPS治疗反应的生物学特征（纵向治疗期间的治疗分析） 症状评估[ATLAS]研究）。目前的融资期将于2019年6月结束。我们提出了一个 融资期限延长三年，至2022年6月。在拟议的三年延期期间，我们的目标是 实现以下目标：具体目标1：在MAPP中获得额外的12个月随访- II SPS. MAPP-II SPS旨在跟踪UCPPS参与者长达三年。通过扩展 从2019年7月到2020年7月的纵向随访时间表，UCPPS参与者的数量如下 三年内，SPS的数量几乎翻了一番（从198个增加到384个）。这些额外的数据将大幅增加 MAPP研究人员检查UCPPS症状随时间变化的模式和预测因素的能力。 具体目标2：观察MAPP-II SPS中的其他ATLAS事件。MAPP-II的一个主要焦点 SPS是将个体参与者表型与UCPPS治疗反应相关联。为了实现这一点， SPS参与者在开始新的UCPPS治疗之前和之后完成表型评估 （ATLAS研究）。额外一年的随访将为发生新的治疗“事件”提供时间， 在这一重要的分析中。具体目标3：对MAPP-II数据进行分析。当前 资金期限为MAPP调查人员提供了足够的时间来分析作为研究的一部分收集的数据。 属物种因此，拟议的为期三年的MAPP-II延长期的最后两年将专门用于 数据分析和手稿准备。

项目成果

The neurobiology of irritable bowel syndrome.

• DOI: 10.1038/s41380-023-01972-w
• 发表时间: 2023-04
• 期刊: MOLECULAR PSYCHIATRY
• 影响因子: 11
• 作者: Mayer, Emeran A.;Ryu, Hyo Jin;Bhatt, Ravi R.
• 通讯作者: Bhatt, Ravi R.

Ceftriaxone inhibits stress-induced bladder hyperalgesia and alters cerebral micturition and nociceptive circuits in the rat: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome research network study.

• DOI: 10.1002/nau.24424
• 发表时间: 2020-08
• 期刊: Neurourology and urodynamics
• 影响因子: 2
• 作者: Holschneider DP;Wang Z;Chang H;Zhang R;Gao Y;Guo Y;Mao J;Rodriguez LV
• 通讯作者: Rodriguez LV

The Seminal Microbiome and Male Factor Infertility.

• DOI: 10.1007/s11930-020-00273-5
• 发表时间: 2020-09
• 期刊: Current sexual health reports
• 影响因子: 2
• 作者: Osadchiy V;Mills JN;Mayer EA;Eleswarapu SV
• 通讯作者: Eleswarapu SV

Pain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction.

• DOI: 10.1016/j.pain.2012.01.002
• 发表时间: 2012-04
• 期刊: Pain
• 影响因子: 7.4
• 作者: Jarcho JM;Mayer EA;Jiang ZK;Feier NA;London ED
• 通讯作者: London ED

Effects of water avoidance stress on peripheral and central responses during bladder filling in the rat: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome (MAPP) research network study.

• DOI: 10.1371/journal.pone.0182976
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Wang Z;Chang HH;Gao Y;Zhang R;Guo Y;Holschneider DP;Rodriguez LV
• 通讯作者: Rodriguez LV