HIVR4P 2023, the 5th HIV Research for Prevention Conference, Lima, Peru, and virtually, 22-26 October 2023

项目摘要 艾滋病规划署制定了雄心勃勃的预防目标和2020年减少艾滋病毒发病率的指标。我们不是在一个 在新冠肺炎大流行之前，这些目标的成功轨迹，并面临艾滋病毒进一步扩大的风险 流行病。监测能力的下降也威胁到我们评估许多国家艾滋病毒流行轨迹的能力。 风险设置。我们面临着持续传播的艰巨挑战，面临着日益扩大的差距和差距。 一级预防。然而，现有的和不断扩大的艾滋病毒感染生物医学预防工具包从未 有和今天一样多的多样性和同样多的高效率选择。非洲的青少年和年轻人 环境和全球主要人群继续承受着艾滋病毒发病率的最大负担，并有 使用和受益于生物医学艾滋病毒预防进展的最大挑战。这些人口将达到 HIVR4P 2023的中心。还将特别关注注射毒品或吸毒的人。 性环境中的物质，以及在预防艾滋病毒方面的研究和服务不足。在……领域 在艾滋病毒疫苗方面，新冠肺炎大流行突显了疫苗接种方面的新威胁。现在是时候了 调查和报告解决犹豫不决和理解接受小说障碍的新方法 艾滋病毒疫苗、预防技术和方法。 HIVR4P 2023，第五届艾滋病毒预防研究会议，于2023年10月22日至26日在 秘鲁利马将是艾滋病毒防治界听取、辩论和权衡新的科学研究的机会 证据，并评估日益复杂的预防格局和下一代研究 问题，包括艾滋病毒疫苗的问题以及疫苗与非疫苗预防的相互作用 医疗模式。利马被选为主办城市，以突出拉丁语在预防研究方面的科学卓越 在此同时，我们还提请注意该地区日益加剧的脆弱性和流行病。 便利每个人参加会议，无论他们的旅行能力或意愿如何，以及 认识到潜在的障碍--包括获得新冠肺炎疫苗的途径--可能会阻止主要利益攸关方 尤其是来自国际旅行艾滋病毒负担很高的国家，HIVR4P 2023将是一个完整的 混合会议。它将把利马的两位观众联系起来，这将为 HIVR4P 2023作为领先的艾滋病毒预防科学中心，并通过虚拟会议平台在线。 HIVR4P 2023的具体目标是： 1.召集世界艾滋病毒预防和相关领域的专家，以促进科学知识， 提出新的研究成果，加强全球科学和社区合作 2.先进的艾滋病毒预防技术和实施办法，以适应以下需要 风险最高的人群包括青少年和年轻人、男男性行为者、吸毒者 全球毒品、性工作者和变性人，以及高负担环境中的妇女和女孩 3.完善艾滋病毒预防研究议程，以反映已查明的机会和知识差距，包括： 下一代艾滋病毒疫苗和bNAbs；犹豫不决和错误信息；更智能的小型 分子，包括长效PrEP、DEPO配方和多用途技术 4.结合新冠肺炎建设取得的显著成功，评估艾滋病毒疫苗研究的现状 疫苗企业，包括非疫苗干预在下一代艾滋病毒疫苗中的作用 药效试验。 该科学计划将由五个主题领域组成：基础科学；PrEP和基于ARV的预防； 疫苗和bNAbs临床试验；其他预防方式和交叉问题；应用和 实施科学。科学计划是由一个多学科的国际组织开发的 委员会审议阶段。交叉方面将在全体会议上强调，这些会议也将把科学与 社区和领导力视角。此外，桥接会话旨在跨越不同的 专题领域为多学科、多视角的对话提供机会，通常使用互动 格式。青年研究人员、基础科学家和相关领域研究人员的参与将是 通过积极征求相关科学知识和提供具体的财政支持而得到加强，此外 到远程访问选项。来自会议的关键科学将在区域内传播和讨论 HIVR4P 2023之后的背景。

Project Summary UNAIDS set ambitious prevention goals and targets for HIV incidence reductions for 2020. We were not on a trajectory for success for those goals before the COVID-19 pandemic, and are at risk of further expansion of HIV epidemics. Declines in surveillance capacity also threaten our ability to assess HIV epidemic trajectories in many settings of risk. We face daunting challenges of ongoing transmission, and of growing gaps and disparities in primary prevention. Yet the existing and expanding toolkit for biomedical prevention of HIV infection has never had as much diversity, and as many high efficacy options, as today. Adolescents and younger adults in African settings and in key populations globally continue to bear the greatest burdens of HIV incidence, and to have the greatest challenges using and benefitting from biomedical HIV prevention advances. This population will be at the center of HIVR4P 2023. A particular focus will also be made on people who inject drugs or who use substances in sexual settings and have been understudied and underserved in HIV prevention. In the field of HIV vaccines, the COVID-19 pandemic highlighted new threats in terms of vaccines hesitancy. It is time now to investigate and report on new ways to addressing hesitancy and to understanding barriers to the uptake of novel HIV vaccines, prevention technologies and approaches. HIVR4P 2023, the 5th HIV Research for Prevention Conference taking place from 22 to 26 October 2023 in Lima, Peru, will be an opportunity for the HIV prevention community to hear, debate and weigh new scientific evidence, and to assess the increasingly complex prevention landscape and the next generation of research questions, including those for HIV vaccines, and the interactions of vaccines with non-vaccine prevention modalities. Lima was chosen as the host city to highlight scientific excellence in prevention research in the Latin American region while also drawing attention to the spiraling vulnerabilities and epidemics in the region. To facilitate everyone’s access to the conference regardless of their ability or willingness to travel, and recognizing that potential obstacles - including access to COVID-19 vaccines - might prevent key stakeholders particularly from countries with a high burden of HIV from travelling internationally, HIVR4P 2023 will be a fully hybrid conference. It will connect the two audiences both in Lima, which will provide a compelling venue for HIVR4P 2023 as a leading center of HIV prevention science, and online via the virtual conference platform. Specific aims for HIVR4P 2023 are to: 1. Convene the world’s experts in HIV prevention and related fields to advance scientific knowledge, present new research findings, and enhance global scientific and community collaborations 2. Advance HIV prevention technologies and implementation approaches that are tailored to the needs of those most at risk including adolescents and young adults, men who have sex with men, people who use drugs, sex workers, and transgender people globally, and women and girls in high-burden settings 3. Refine HIV prevention research agendas to reflect identified opportunities and knowledge gaps, including: Next generation HIV vaccines and bNAbs; hesitancy and misinformation; smarter delivery systems for small molecules, including longer-acting PrEP, depo formulation and multi-purpose technologies 4. Assess the state of the art of HIV vaccine research in light of the remarkable success of the COVID-19 vaccine enterprise, including the role of non-vaccine interventions in the next generation of HIV vaccine efficacy trials. The scientific program will consist of five thematic areas: basic science; PrEP and ARV-based prevention; Vaccines and bNAbs clinical trials; other prevention modalities and cross-cutting issues; applied and implementation science. The scientific program is developed by a multi-disciplinary international Organizing Committee. Cross-cutting aspects will be highlighted in plenary talks that also connect the science with community and leadership perspectives. Additionally, bridging sessions are designed to cut across the different thematic areas to provide opportunities for multi-disciplinary, multi-perspective dialogues, often using interactive formats. The participation of young researchers, basic scientists and researchers in related fields will be strengthened by active solicitation of relevant science and the provision of specific financial support, in addition to remote-access options. Key science from the conference will be disseminated and discussed in regional contexts following HIVR4P 2023.