Effectiveness of combination HIV preventive interventions for young Thai MSM
泰国年轻男男性接触者联合艾滋病毒预防干预措施的有效性
基本信息
- 批准号:9300829
- 负责人:
- 金额:$ 62.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-07-01 至 2020-06-30
- 项目状态:已结题
- 来源:
- 关键词:AIDS preventionAcuteAddressAdherenceAsiaAwarenessCar PhoneCaringCenters for Disease Control and Prevention (U.S.)ClinicCohort StudiesCollaborationsCommunitiesCost AnalysisCost MeasuresCost SavingsCounselingDataEffectivenessEnrollmentEpidemicFoundationsGoalsHIVHIV InfectionsHIV SeropositivityHealth PromotionHuman immunodeficiency virus testIncidenceIndividualInfectionInfection preventionInterventionLGBT HealthLubricantsMethodsOralParticipantPersonsPhasePopulationPreventionPrevention strategyPreventive InterventionProceduresProcessProstitutionQualitative MethodsRecording of previous eventsReportingResearchResearch DesignRightsRiskRisk ReductionScoring MethodServicesStructural ModelsTenofovirTestingThailandTimeTreatment CostUniversitiesWorkagedbasebehavior changecommunity consultationcondomscostcost effectivecost effectivenessdensitydesigndisability-adjusted life yearsdiscounteffectiveness trialempowermentemtricitabineexperiencehigh riskmalemale sex workermembermenmen who have sex with menopen labelpre-exposure prophylaxispublic health relevancesexsexual risk takingtruvadauptakeyoung manyoung men who have sex with men
项目摘要
DESCRIPTION (provided by applicant): This Thai-US collaborative application seeks to develop and conduct a non-randomized effectiveness and cost-effectiveness study of a multi-level combination HIV preventive intervention with and without daily oral Tenofovir/Emtricitabine (Truvada) pre-exposure prophylaxis (PrEP) with mobile phone-based SMS adherence support among young men who have sex with men (YMSM) in Bangkok, Thailand. The current epidemic of HIV among Thai YMSM (men aged 18-26) is marked by high HIV incidence (5-12/100py) despite current prevention and treatment efforts, and rates are highest among the youngest men, aged 18-21, and among the subset of YMSM who sell sex. The proposed combination intervention will include individual level components: frequent HIV testing, risk reduction counseling, condom and lubricant distribution, and behavior change counseling; community awareness and mobilization; and an open label offer of PrEP with SMS (FrontlineSMS) adherence support. Participants will include Thai YMSM engaged in sex work or with a history of recent (in the previous 12 months) selling sex. The proposed study will be conducted by Johns Hopkins, Mahidol, and Emory Universities; The Thai MOPH-US CDC Collaboration (TUC) and its Silom Community Clinic @ Trop Med (SCC); and community partners including SWING, a sex worker empowerment and health promotion group; Rainbow Sky, an LGBT health and rights group; and APCOM, the Asia-Pacific Community of MSM. This group combines unique expertise, access, and experience in working with YMSM in this hyper-epidemic context. The study will include a formative phase using qualitative and community engagement methods to refine the intervention; a pilot; the open label intervention assessing effectiveness of combination interventions with and without PrEP and SMS adherence support with an HIV infection endpoint; and a costing and cost-effectiveness assessment which will measure the costs associated with the combined intervention, the number of infections averted through PrEP use, discounted treatment costs save, and assess whether the intervention packages are cost- saving, cost effective, or not cost-effective. The effectiveness study has been powered on the comparison of person time on PrEP versus not on PrEP and will employ propensity score methods to reduce the potential bias inherent in the self-selection design. In all
the study proposes to enroll 1240 YMSM, 620 who choose PrEP and 620 who do not choose PrEP.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Christopher C. Beyrer其他文献
Christopher C. Beyrer的其他文献
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{{ truncateString('Christopher C. Beyrer', 18)}}的其他基金
IAS 2023, the 12th IAS Conference on HIV Science, Brisbane, Australia, and virtually, 23-26 July 2023
IAS 2023,第 12 届 IAS HIV 科学会议,澳大利亚布里斯班,虚拟会议,2023 年 7 月 23-26 日
- 批准号:
10696505 - 财政年份:2023
- 资助金额:
$ 62.24万 - 项目类别:
HIVR4P 2023, the 5th HIV Research for Prevention Conference, Lima, Peru, and virtually, 22-26 October 2023
HIVR4P 2023,第五届艾滋病毒预防研究会议,秘鲁利马,虚拟会议,2023 年 10 月 22-26 日
- 批准号:
10617933 - 财政年份:2023
- 资助金额:
$ 62.24万 - 项目类别:
The 24th International AIDS Conference (AIDS 2022), 29 July-2 August 2022, Montreal, Canada and virtually
第 24 届国际艾滋病大会 (AIDS 2022),2022 年 7 月 29 日至 8 月 2 日,加拿大蒙特利尔
- 批准号:
10481133 - 财政年份:2022
- 资助金额:
$ 62.24万 - 项目类别:
11th IAS Conference on HIV Science (IAS 2021), Berlin, Germany, 18-21 July 2021
第 11 届 IAS HIV 科学会议 (IAS 2021),德国柏林,2021 年 7 月 18-21 日
- 批准号:
10254560 - 财政年份:2021
- 资助金额:
$ 62.24万 - 项目类别:
HIV Research for Prevention Conference, HIVR4P 2020
HIV 预防研究会议,HIVR4P 2020
- 批准号:
9925854 - 财政年份:2020
- 资助金额:
$ 62.24万 - 项目类别:
23rd International AIDS Conference (AIDS 2020), San Francisco and Oakland, United States, 6-10 July 2020
第 23 届国际艾滋病大会 (AIDS 2020),美国旧金山和奥克兰,2020 年 7 月 6-10 日
- 批准号:
10004757 - 财政年份:2020
- 资助金额:
$ 62.24万 - 项目类别:
Effectiveness of combination HIV preventive interventions for young Thai MSM
泰国年轻男男性接触者联合艾滋病毒预防干预措施的有效性
- 批准号:
10084364 - 财政年份:2015
- 资助金额:
$ 62.24万 - 项目类别:
Johns Hopkins HIV Epidemiology and Prevention Sciences Training Program
约翰·霍普金斯大学艾滋病流行病学和预防科学培训计划
- 批准号:
9897479 - 财政年份:2013
- 资助金额:
$ 62.24万 - 项目类别:
Johns Hopkins HIV Epidemiology and Prevention Sciences Training Program
约翰·霍普金斯大学艾滋病流行病学和预防科学培训计划
- 批准号:
8879021 - 财政年份:2013
- 资助金额:
$ 62.24万 - 项目类别:
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