Ohio Valley Node-Network (OVNN) of the NIDA Clinical Trials Network

项目摘要-摘要： 自2000年成立以来，俄亥俄州山谷节点（OVN）一直是NIDA最富有成效的项目之一。 临床试验网络（CTN）节点，领导和参与多中心试验。在本申请中， OVN已扩展为网络的节点：俄亥俄州山谷节点网络（OVNN）。OVNN包括 8个原始OVN站点，位于6个州，每年治疗超过225，000名患者;以及3个 基于实践的研究网络（PBRN）。两个是全州范围的初级保健PBRN， 协作俄亥俄州查询网络（COIN）和威斯康星州研究和教育网络（WREN）， 这些诊所加起来有350多个诊所，每年治疗400多万病人。三是 位于印第安纳州的全州药房PBRN，包括168家药房，提供150万张处方 每年。这些中西部研究中心和合作伙伴关系将为CTN临床试验提供所需的多样性。的 OVNN研究核心是OVNN的驱动力，由最重要的专家之一Winhusen博士领导 在临床实践环境中进行多地点成瘾临床试验。OVNN的合作研究者包括 初级保健（老年人）、急诊医学（里昂）和儿科急诊医学（Grupp- 基于实践的研究。OVN研究实施团队的7名成员带来了72年的经验， 结合开展CTN临床试验的经验。应用程序的主要目标是执行 研究需要告知有效物质使用障碍（SUD）预防的临床实践指南 一般医疗保健环境中的治疗，这在很大程度上是缺乏的，但越来越需要， 具体侧重于研究，以解决阿片类药物滥用流行问题。我们的研究计划包括 实用的临床试验测试干预措施，以预测，预防和应对初级保健中的阿片类药物滥用; 通过将在紧急情况下接受过量治疗的患者联系起来， 通过一种新的基于同行的干预措施，使医学部门能够接受SUD治疗;并减少 通过对接受丁丙诺啡治疗的患者进行基于药物的检测来预防HIV和HCV的传播。

Project Summary-Abstract: Since its establishment in 2000, the Ohio Valley Node (OVN) has been one of the most productive of NIDA's Clinical Trials Network (CTN) nodes, both in leading and participating in multi-site trials. In this application the OVN has been expanded to be a node of networks: the Ohio Valley Node-Network (OVNN). The OVNN includes eight original OVN sites, which are located in 6 states and treat more than 225,000 patients per year; and three additional practice based research networks (PBRNs). Two are state-wide primary care PBRNs, the Collaborative Ohio Inquiry Network (COIN) and the Wisconsin Research and Education Network (WREN), which, combined, include more than 350 practices and treat more than 4 million patients per year. The third is a state-wide pharmacy PBRN in Indiana, which includes 168 pharmacies that fill 1.5 million prescriptions annually. These Midwestern sites and partnerships will contribute needed diversity to CTN clinical trials. The OVNN Research Core is the driving force of the OVNN and is led by Dr. Winhusen, one of the foremost experts in conducting multi-site addiction clinical trials in clinical practice settings. The OVNN co-investigators include experts in primary care (Elder), emergency medicine (Lyons), and pediatric emergency medicine (Grupp- Phelan) practice-based research. The 7 members of the OVN research-implementation team bring 72 years of combined experience conducting CTN clinical trials. A primary goal of the application is to conduct the research needed to inform clinical practice guidelines for effective substance use disorder (SUD) prevention and treatment in general medical care settings, which are largely lacking but increasingly needed, with a specific focus on research to address the opioid abuse epidemic. Our proposed research agenda includes pragmatic clinical trials testing interventions to predict, prevent, and respond to opioid misuse in primary care; to reduce the reoccurrence of opioid overdose by linking patients treated for an overdose in emergency medicine departments to SUD treatment through a novel peer-based intervention; and to reduce the transmission of HIV and HCV through pharmacy-based testing for buprenorphine-treated patients.