New York Obesity Research Center

 描述(由申请人提供)：纽约肥胖营养研究中心(NYONRC)的主要目标是通过其核心服务、试点与可行性和充实计划，资助哥伦比亚大学和阿尔伯特·爱因斯坦医学院研究肥胖的研究人员。该中心的主题包括：肥胖的病因、病理生理学和并发症；治疗策略；体重调节的生理学；研究营养和肥胖的新工具和战略的开发；以及研究营养和肥胖的科学家的培训和发展。NYONRC的一个特别优势是明确致力于促进多学科研究，将与营养、代谢和行为生物学有关的基本观察与将这些见解应用于临床预防方法相结合 以及肥胖症的治疗。我们基础的规模和广度为合作和生产力提供了坚实的基础。在本周期内，研究基础已从75个大幅增加到109个资助成员。2014年，NYONRC成员在155笔与肥胖相关的NIH赠款中担任PI，总直接成本为55,939,716美元(19,032,744 NIDDK美元)，55家基金会和制药实体支持与肥胖相关的赠款，总额为9,595,751美元。此外，成员还包括十个NIH培训助学金、三个P01计划项目、哥伦比亚大学CTSA以及十个K系列和三个F31研究生奖项的导师。这些努力得到了我们的三个生物医学研究核心的支持：人类表型分析、动物表型分析和分子生物学/分子遗传学。自上次提交以来，核心已向91名成员提供了约25,000项服务，其中包括人类表型核心提供的约9,000项服务，动物表型核心提供的14,000项服务，以及分子遗传学/分子生物学核心提出的涉及10,000多个样本的&gt；3000项服务请求。。该研究基地还得到了一个非常成功的试点和可行性项目的支持，该项目得到了赞助机构的补贴，自上次提交以来，该项目向10名研究人员提供了82万美元的奖励。NYONRC是一个充满活力的企业，拥有强大的制度支持，使其在促进肥胖研究的新颖和协作科学的同时，得以发展和蓬勃发展。

 DESCRIPTION (provided by applicant): The New York Obesity Nutrition Research Center (NYONRC) has as its primary aim to convene and support - by its Core Services, Pilot & Feasibility and Enrichment programs - funded investigators at Columbia University and the Albert Einstein College of Medicine studying obesity. The themes for this Center include: the etiology, pathophysiology and complications of obesity; treatment strategies; the physiology of weight regulation; development of new tools and strategies for the study of nutrition and obesity; and the training and development of scientists to study nutrition and obesity. A particular strength of the NYONRC, by design, is an explicit commitment to the promotion of multidisciplinary research that integrates basic observations relating to nutritional, metabolic an behavioral biology, with the application of these insights to clinical approaches to the prevention and treatment of obesity. The size and breadth of our base has provided a strong basis for collaborations and productivity. During the current cycle, the research base has grown substantially from 75 to 109 funded members. In 2014, NYONRC members were PIs on 155 obesity-related NIH grants totaling $55,939,716 in direct costs ($19,032,744 NIDDK) and 55 foundations and pharmaceutical entities supported obesity-related grants totaling $9,595,751. Furthermore, members are PIs of ten NIH training grants, three P01 program projects, the CTSA at Columbia, and mentors of ten K series and three F31 graduate awards. These efforts are supported by our three Biomedical Research Cores: Human Phenotyping, Animal Phenotyping and Molecular Biology/Molecular Genetics. Since the last submission, the Cores have provided ~25,000 services to 91 members, including ~9000 services now provided by the Human Phenotyping Core, 14,000 services from the Animal Phenotyping Core and >3000 service requests involving more than 100,000 samples by the Molecular Genetics/Molecular Biology Core. . The research base is also supported by a highly successful Pilot & Feasiblity Program - subsidized by the sponsoring institutions - that awarded $820,000 to 10 investigators since the last submission. The NYONRC is a dynamic enterprise that has strong institutional support permitting it to evolve and thrive as it fosters novel and collaborative science in the study of obesity.