Omics core

组学摘要 这是集成 CHAIN Center OMICS 核心的延续。其复杂性和相互交织性 蛋白质组学、代谢组学和生物信息学强烈表明，最有益和最合理的步骤 本轮申请旨在将这三个实体归为一个整体，以实现更紧密、更紧密的联系。 有效利用技术有利于中心研究人员进行的研究。各组件 这个“组学核心”（蛋白质组学由 Ciborowski 博士领导，代谢组学由 Siuzdak 博士领导，生物信息学 现在由 Guda 博士领导）在过去的密切合作下带来了广泛的各自专业知识 五年的 CHAIN 融资。 CHAIN 中心及其研究人员提供先进的分析和支持 生物信息学技术平台将按照以下具体目标完成： 1. 提供 通过质谱和生物信息学平台进行蛋白质组学和代谢组学分析技术 用于全面的数据分析； 2. 提供实验设计、数据分析和软件方面的专业知识 支持与该中心相关的研究人员所需的研究的工具； 3. 开发新方法 蛋白质组学和代谢组学研究的分析技术，以满足当前和未来的需求 CHAIN 调查员； 4. 为人类提供基因组规模的技术和最先进的生物信息学工具 中心的需要； 5. 协调该核心在神经艾滋病和中心各个层面的工作 社区。这些具体目标旨在实现中心的目标，三位核心研究人员 不仅带来了蛋白质组学、代谢组学和生物信息学方面的重要专业知识，而且还拥有良好的 对艾滋病毒及其神经生物学等慢性疾病的了解，以及在这方面的经验 神经艾滋病研究，这提高了 CHAIN 中心研究人员成功的可能性。其中之一 期望蛋白质组学实验的结果将与代谢组学数据整合，并通过 在该核心中使用生物信息学分析工具，协作努力将导致综合数据收集， 同时多样化和集成的共享和分析能力，不仅使我们能够 研究人员不仅要实现他们的科学目标，还要为中心的艾滋病毒感染提供独特的资源 神经系统和衰老。进一步整合这一核心，将使其领导者认识到哪些 该中心的研究人员将受益于其他组学支持。此外，所有信息将被共享 通过行政核心提供的机制，以面对面（小型研讨会）或在线（网络研讨会）的形式 会议以及多种教育途径，即与数据库、专题和相关的教程 教科书。博士。 Siuzdak、Ciborowski 和 Guda 在吸引新调查人员方面有着良好的记录。

Omics Abstract This is a continuation of an integrated CHAIN Center OMICS core. The complexity and intertwining of proteomics, metabolomics and bioinformatics strongly indicated that the most beneficial and logical step for this round of application is to group these three entities under one umbrella allowing for closer and more effective use of technology to the advantage of research conducted by center’s investigators. Each component of this ‘Omics Core (Proteomics led by Dr. Ciborowski, Metabolomics led by Dr. Siuzdak and Bioinformatics now led by Dr. Guda) brings extensive respective expertise supported by close collaboration during the past five years of CHAIN funding. Support of CHAIN Center and its investigators with advanced analytical and bioinformatics technology platforms will be accomplished according to the following specific aims: 1. To provide analytical technologies in proteomics and metabolomics via mass spectrometry and bioinformatics platforms for comprehensive data analyses; 2. To provide expertise in experimental design, data analyses and software tools in support of studies needed by investigators associated with this center; 3. To develop new approaches and analytical techniques for proteomic and metabolomics studies to meet the current and future needs of CHAIN investigators; 4. To enable genome-scale technology and state-of-the-art bioinformatic tools for the needs of the Center; and 5. To coordinate efforts of this core at all levels within the neuroAIDS and Center’s communities. These specific aims are designed to meet the Center’s goals, and the three Core investigators not only bring significant expertise in proteomics, metabolomics and bioinformatics but also have a good understanding of chronically developing condition such as HIV and its neurobiology, and experience in neuroAIDS studies, which facilitate the likelihood of success of CHAIN Center investigators. One of expectations is that results of proteomics experiments will be integrated with metabolomics data, and through the use of bioinformatics analysis tools in this Core a collaborative effort will result in integrated data collection, sharing and analysis capabilities that are simultaneously divers and integrated, not only enabling our investigators to meet their scientific aims but generating a unique resource for HIV infection of the central nervous system and ageing. Further integration of this core, will enable its leaders to recognize which researchers of this center would benefit from the other omics support. Moreover, all information will be shared via mechanisms provided by the administrative core in form of in-person (mini symposia) or on-line (webinars) meetings as well as multiple educational avenues, i.e. tutorials associated with databases, monographic and textbooks. Drs. Siuzdak, Ciborowski and Guda have solid track record of attracting new investigators.