Core C: Clinical Sciences Core

项目摘要 第三海岸CFAR核心C：临床科学核心（CSC） 在芝加哥男男性行为者中艾滋病毒流行日益恶化的背景下，临床研究所 第三海岸艾滋病研究中心（TC CFAR）的科学核心（CSC）旨在促进和 加强以患者为导向的临床和转化艾滋病毒研究，并与其他TC CFAR核心合作， 实现科学工作组（SWG）的战略重点，称为结束艾滋病毒。具体目标是：1） 优化目标人群的招募以及临床数据和生物样本的获取; 2）提供 研究设计、推行及联络服务;及3）推动创新研究， 来自多个学科的研究人员通过传播临床艾滋病毒研究的进展， 合作和指导新的调查人员。为了实现这些目标，CSC将实施创新的 提高现有基础设施优势价值的战略，目前包括世界一流的 研究人员和研究实验室在西北大学（NU）和社会科学的优势， 芝加哥大学（UC）。CSC还将协同艾滋病毒研究的潜在潜力， 社区合作伙伴，包括芝加哥公共卫生部和芝加哥联盟 社区卫生服务，它有一个功能电子健康记录系统和数据仓库， 将用于临床/转化研究。公务员事务委员会推出的创新措施包括： 以网络为基础的招聘门户，以扩大跨机构的学科招聘，特别是难以找到的 患者，如急性/近期感染艾滋病毒的患者，ii）生物标本登记处，以最大限度地共享 有价值的标本，而不增加成本，iii）和一个足智多谋的数据分析师，一个经验丰富的研究 导航员和程序协调员，所有人都作为数据库团队的一部分工作， 研究人员的数据和研究资源。定期召开“与研究人员见面论坛”， 提高患者及其提供者的研究素养将使CFAR调查人员锚到艾滋病毒社区， 而“午餐和学习”系列中的“临床艾滋病合作”将揭示研究成果， 合作机会，促进思想交流，促进优秀的指导。一系列 研究开发和实施服务，包括支持临床研究设计、统计 分析、监管批准、与研究相关专业服务（包括活检）的联系，以及 专业实验室服务将改变艾滋病毒研究的能力和效率。总的来说，CSC将 成倍增加TC CFAR中杰出调查人员的数量，并促进发现， 推动我们实现结束艾滋病毒流行的目标。

PROJECT SUMMARY THIRD COAST CFAR CORE C: CLINICAL SCIENCES CORE (CSC) Against the backdrop of a worsening HIV epidemic among Chicago's men who have sex with men, the Clinical Science Core (CSC) of the Third Coast Center for AIDS Research (TC CFAR) is structured to facilitate and enhance patient-oriented clinical and translational HIV research, and in concert with the other TC CFAR Cores, actualize the strategic focus of the Scientific Working Group (SWG) called END HIV. The specific aims are: 1) to optimize recruitment of targeted populations and access to clinical data and biological samples; 2) to provide research design, implementation and liaison services; and 3) to catalyze innovative research involving investigators from multiple disciplines by disseminating advances in clinical HIV research that spark new collaborations and by mentoring new investigators. To achieve these aims, the CSC will implement innovative strategies to increase the value of existing infrastructure strengths, which currently include world-class researchers and research laboratories at Northwestern University (NU) and strengths in social sciences at the University of Chicago (UC). The CSC will also synergize latent potential for HIV research that exists in strong community partners including the Chicago Department of Public Health and the Alliance of Chicago Community Health Services, which has a functional electronic health records system and data warehouse that will be leveraged for clinical/translational research. Innovations introduced by the CSC include: i) a centralized web-based recruitment portal to expand cross-institutional subject recruitment, particularly of hard-to-find patients such as those with acute/recent HIV infection, ii) a biological specimen registry to maximize sharing of valuable specimens without adding cost, iii) and a resourceful data analyst, a highly experienced research navigator and program coordinator, all working as part of a Database Team empowered to interconnect researchers with data and research resources. Regularly convened “Meet Your Researcher Forums” to improve research literacy of patients and their providers will anchor CFAR investigators to the HIV community, while the Clinical HIV Collaborative nested within the Lunch and Learn series will uncover research collaboration opportunities, foster cross-fertilization of ideas and facilitate excellent mentoring. A range of research development and implementation services, including support for clinical research design, statistical analysis, regulatory approvals, linkage to research-related professional services (including biopsies) and specialized laboratory services will transform the capacity and efficiency of HIV research. Overall the CSC will exponentially increase the number of outstanding investigators in the TC CFAR and fuel discoveries that will propel us towards the goal of ending the HIV epidemic.