Core C: Clinical Sciences Core

项目总结 第三海岸CFAR核心C：临床科学核心(CSC) 在芝加哥男男性行为者中艾滋病毒流行日益恶化的背景下，临床 第三海岸艾滋病研究中心(TC CFAR)的科学核心(CSC)旨在促进和 加强以患者为导向的临床和转化性艾滋病毒研究，并与其他TC CFAR核心协调一致， 落实科学工作组(SWG)称为结束艾滋病毒的战略重点。具体目标是：1) 优化目标人群的招募和临床数据和生物样本的获取；2)提供 研究设计、实施和联络服务；以及3)促进创新研究，包括 来自多个学科的研究人员通过传播临床艾滋病毒研究的进展，引发新的 合作和指导新的调查人员。为了实现这些目标，证监会将实施创新 提升现有基础设施优势价值的战略，目前包括世界级 西北大学(NU)的研究人员和研究实验室以及在社会科学方面的优势 芝加哥大学(UC)。CSC还将协同现有的强大的艾滋病毒研究的潜在潜力 社区合作伙伴，包括芝加哥公共卫生部和芝加哥联盟 社区卫生服务，它拥有一个功能强大的电子健康记录系统和数据仓库， 将用于临床/转化性研究。CSC推出的创新包括：i)集中式 基于网络的招聘门户网站，扩大跨机构学科招聘，特别是难找的学科招聘 患者，如那些急性/最近感染艾滋病毒的患者，二)生物标本登记册，以最大限度地共享 有价值的标本而不增加成本，III)和足智多谋的数据分析师，经验丰富的研究 导航员和程序协调员，他们都是授权互联的数据库团队的一部分 拥有数据和研究资源的研究人员。定期召开“与您的研究人员见面论坛”，以 提高患者及其提供者的研究素养将把CFAR的调查人员固定在艾滋病毒社区， 而嵌套在午餐和学习系列中的临床艾滋病毒合作将揭示研究 合作机会，促进思想的交流和促进优秀的指导。一系列 研究开发和实施服务，包括支持临床研究设计、统计 分析、监管批准、与研究相关的专业服务(包括活组织检查)的联系以及 专门的实验室服务将改变艾滋病毒研究的能力和效率。总体而言，CSC将 成倍增加TC CFAR和燃料发现方面的杰出调查人员数量，将 推动我们朝着结束艾滋病毒流行病的目标前进。

PROJECT SUMMARY THIRD COAST CFAR CORE C: CLINICAL SCIENCES CORE (CSC) Against the backdrop of a worsening HIV epidemic among Chicago's men who have sex with men, the Clinical Science Core (CSC) of the Third Coast Center for AIDS Research (TC CFAR) is structured to facilitate and enhance patient-oriented clinical and translational HIV research, and in concert with the other TC CFAR Cores, actualize the strategic focus of the Scientific Working Group (SWG) called END HIV. The specific aims are: 1) to optimize recruitment of targeted populations and access to clinical data and biological samples; 2) to provide research design, implementation and liaison services; and 3) to catalyze innovative research involving investigators from multiple disciplines by disseminating advances in clinical HIV research that spark new collaborations and by mentoring new investigators. To achieve these aims, the CSC will implement innovative strategies to increase the value of existing infrastructure strengths, which currently include world-class researchers and research laboratories at Northwestern University (NU) and strengths in social sciences at the University of Chicago (UC). The CSC will also synergize latent potential for HIV research that exists in strong community partners including the Chicago Department of Public Health and the Alliance of Chicago Community Health Services, which has a functional electronic health records system and data warehouse that will be leveraged for clinical/translational research. Innovations introduced by the CSC include: i) a centralized web-based recruitment portal to expand cross-institutional subject recruitment, particularly of hard-to-find patients such as those with acute/recent HIV infection, ii) a biological specimen registry to maximize sharing of valuable specimens without adding cost, iii) and a resourceful data analyst, a highly experienced research navigator and program coordinator, all working as part of a Database Team empowered to interconnect researchers with data and research resources. Regularly convened “Meet Your Researcher Forums” to improve research literacy of patients and their providers will anchor CFAR investigators to the HIV community, while the Clinical HIV Collaborative nested within the Lunch and Learn series will uncover research collaboration opportunities, foster cross-fertilization of ideas and facilitate excellent mentoring. A range of research development and implementation services, including support for clinical research design, statistical analysis, regulatory approvals, linkage to research-related professional services (including biopsies) and specialized laboratory services will transform the capacity and efficiency of HIV research. Overall the CSC will exponentially increase the number of outstanding investigators in the TC CFAR and fuel discoveries that will propel us towards the goal of ending the HIV epidemic.