Vascular Biology Training Grant

项目摘要 血管生物学领域的研究改变了我们预防、监测和治疗心血管疾病的方式。 疾病特别是，过去五十年的努力为患者护理提供了变革性的进步， 提高了预期寿命，并改善了受血管病变影响的个体的生活质量。 然而，挑战依然存在。此外，修复手术和治疗方面的改进， 以前致命的心血管异常，揭示了与人口相关的新病理学 现在能在先天性疾病中存活。通过对下一代的培训，我们将能够 不断改进心血管护理，以解决新出现的临床问题。这项建议 寻求更新的血管生物学培训计划（VBTP）在加州大学洛杉矶分校。进入第四个周期， 自2002年以来，该方案已为46名研究生和博士后研究员提供了培训。其程度的 成功与否可以从受训人员目前在学术和工业部门任职的高比例来评估， 我们的学员发表的169份研究报告的质量。在这个程序的下一个迭代中，我们的中央 目标仍然是为下一代血管生物学家提供强有力的跨学科培训。到 为了实现这一目标，我们正在更新我们的教育方法的结构，以应对更多的 学员的多元化需求及未来劳动力不断增长的需求。具体而言是 该计划已经发展到采用多导师制方法，将新兴技术的培训纳入其中， 并为工业和医学的互动接触创造机会。通过这种方式，我们的目标是 培养知识面广、技术面广、能整合信息的科学家 从多个领域，并将这些信息应用于解决该领域的新挑战。 该计划还强调职业发展，研究诚信和扩大 一群代表性不足的科学家作为洛杉矶唯一的血管生物学培训基金 我们的项目是一个地区和八个在加州的状态之一，我们的计划是由一个庞大的候选人池的追捧。 这使我们能够选择高素质和承诺的学员，并建立一个学者社区， 专注于血管生物学。重要的是，加州大学洛杉矶分校有大量的跨学科小组 对血管生物学的各个方面感兴趣，并且位于一家大型研究医院旁边。正是这种 社区，构成了下一代科学家独特的培训计划的支柱。 在这里，我们要求资金继续支持7前和3博士后研究员/年，其中2-3 每年有新的研究生和1-2名博士后研究员进入该计划。前一 该计划的成功和教师的承诺已经引起了学校的热情， 加州大学洛杉矶分校医学、学院和研究生部。每个实体都承诺在体制上 支持和协同作用，以实现这一计划的新目标。

Project Summary Research in the field of vascular biology has changed how we prevent, monitor, and treat cardiovascular disease. In particular, efforts in the last fifty years provided transformative advancements in patient care, raised life expectancy, and improved the quality of life of those individuals affected by vascular pathologies. However, challenges still remain. Furthermore, the improvements in reparative surgery and treatment of previously lethal cardiovascular anomalies, brought to light new pathologies associated with a population that now survives congenital diseases. It is through training of the next generation that we will be able to make constant improvements in cardiovascular care to address emerging clinical problems. This proposal seeks renewal for the Vascular Biology Training Program (VBTP) at UCLA. Entering its 4th cycle, the program has provided training for 46 graduate students and post-doctoral fellows since 2002. Its degree of success can be assessed by the high percentage of trainees now in academic and industry positions and by the caliber of the 169 studies published by our trainees. In this next iteration of the program, our central goal remains to offer robust, interdisciplinary training to the next generation of vascular biologists. To achieve this goal, we are renewing the structure of our educational approach to respond to the more diverse needs of our trainees and the expanding demands of the future workforce. Specifically, the program has evolved to adopt a multi-mentorship approach, incorporate training in emerging technologies, and create opportunities for interactive exposure to industry and medicine. In this manner, we aim to develop scientists who are intellectually broad and have technical versatility, able to integrate information from multiple fields, and apply this information toward the resolution of emerging challenges in the field. The program also places a strong emphasis in career development, research integrity, and on enlarging the pool of underrepresented scientists. As the only Vascular Biology Training Grant in the Los Angeles area and one of eight in the state of California, our program is sought-after by a large pool of candidates. This allows us to select highly qualified and committed trainees and to build a community of scholars with strong focus in vascular biology. Importantly, UCLA has a large number of interdisciplinary groups interested in diverse aspects of vascular biology and located next to a large research hospital. It is this community that constitues the pillars of a unique training program for the next generation of scientists. Here, we request funds to continue the support for 7 pre- and 3 post-doctoral fellows/year, in which 2-3 new graduate students and 1-2 post-doctoral fellows will enter the program each year. The previous success of the program and the commitment of its faculty has engendered enthusiasm within the School of Medicine, College, and the Graduate Division at UCLA. Each of these entities have pledged institutional support and programatic synergy to accomplish the renewed goals of this program.