Sources, Transport, Exposure and Effects of PFASs (STEEP)

PFAS 的来源、传输、暴露和影响 (STEEP)

• 批准号: 9904670
• 负责人: Elsie Mareca Sunderland
• 金额: $ 20.18万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9904670
• 关键词: Address; Affect; Age; Alkanesulfonates; Anoxia; Antibody Formation; Area; Automobile Driving; Biological Markers; Carbon; Characteristics; Child; Chronic; Code; Cods; Collaborations; Detection; Environment; Environmental Risk Factor; Exposure to; Fingerprint; Fire - disasters; Fishes; Food Webs; Fresh Water; Gap Junctions; Geological Survey; Goals; Hazardous Waste Sites; Head; Health; Human; Immune; Immunologic Markers; Immunosuppression; Individual; Industrialization; Industry; Joints; Knowledge; Laboratories; Lead; Length; Link; Location; Malignant Neoplasms; Measurement; Measures; Metabolic; Metabolic Diseases; Metabolism; Methods; Military Personnel; Modeling; Outcome; Outcomes Research; Poison; Population; Positioning Attribute; Public Health; Research; Research Priority; Risk; Risk Assessment; Safety; Site; Source; Statistical Methods; Superfund; Time; Tissues; Toxicology; Toxoids; Tracer; Training; Training Activity; United States; Universities; Vaccines; Water; Water Supply; Work; base; chemical property; consumer product; contaminated drinking water; drinking water; exposed human population; exposure pathway; fighting; ground water; hydrology; immune function; immunotoxicity; improved; improved mobility; novel; obesity risk; persistent organic pollutants; population based; remediation; reproductive; response; response biomarker; superfund site; uptake; vector; virtual

PROJECT SUMMARY/ABSTRACT More than 600 sites across the U.S. are contaminated by poly and perfluroalkyl substances (PFASs) but the extent of transport away from these sites and entry into human exposure pathways (drinking water and fish) is virtually unknown. This information is critical for assessing human health risks associated with exposures to PFASs from contaminated sites, such as the metabolic and immune outcomes that are being investigated in Projects 2 and 3 of the STEEP Center. This project will measure a suite of PFASs present in drinking water and fish near the Joint Base Cape Cod (JBCC), a region contaminated by historical fire training activity and designated as a National Priorities List site. For Aim 1, novel statistical methods will be used to fingerprint profiles of PFASs measured in fish and drinking water around the JBCC site. PFAS profiles in drinking water and fish will be compared to those from consumer products (wastewater influent) to identify exposures originating from contaminated sites. For Aim 2, we will leverage from long-term research by the U.S. Geological Survey (USGS) near the JBCC site characterizing hydrological flow paths and groundwater geochemistry to better understand how environmental factors influence the transport and transformations of PFASs away from contaminated sites and into drinking water supplies. We will use a combination of field measurements in collaboration with Project 4, and advanced geochemical modeling that leverages from prior USGS hydrological research. For Aim 3, we will extend knowledge on the spatial domain of groundwater transport to include uptake by fish. Fish will be exposed to experimental incubations along the groundwater transport plume and we will assess toxicological biomarkers for immune and metabolic responses. One of the major expected outcomes of this work will be better understanding of the spatial extent of elevated PFAS concentrations in fish and drinking water from contaminated sites, which will allow improved characterization of exposed populations and risks. This project will provide a novel contribution at the nexus between geochemistry and health by linking the geochemical factors affecting PFAS transport and mobility to human health risks associated with exposure. !

项目总结/摘要 美国有600多个地点受到聚和全氟烷基物质（PFAS）的污染。 但从这些场所转移到人体接触途径（饮用水）的程度 水和鱼，几乎是未知的。这些信息对于评估人类健康风险至关重要 与暴露于污染场所的PFAS有关，如代谢和免疫系统 STEEP中心项目2和项目3正在研究的成果。该项目将 测量科德角联合基地（JBCC）附近饮用水和鱼类中存在的一系列PFAS， 一个被历史上的消防训练活动污染的地区，并被指定为国家优先名单 绝佳的价钱对于目标1，将使用新的统计方法来确定在以下条件下测量的PFAS的指纹图谱： JBCC现场周围的鱼类和饮用水。PFAS在饮用水和鱼类中的分布将被 与来自消费品（废水流入物）的接触进行比较，以确定 污染的地方。对于目标2，我们将利用美国地质调查局的长期研究， 在JBCC场址附近进行勘测（美国地质勘探局），确定水文水流路径和地下水特征 地球化学，以更好地了解环境因素如何影响运输， 将全氟辛烷磺酸从受污染场地转化为饮用水供应。我们将 与项目4合作，使用现场测量组合， 利用美国地质勘探局先前的水文研究进行建模。对于目标3，我们将扩展 关于地下水迁移空间领域的知识，包括鱼类的吸收。鱼会 暴露于实验孵化沿着地下水运输羽，我们将评估 免疫和代谢反应的毒理学生物标志物。主要预期成果之一 这项工作的重点是更好地了解鱼类中PFAS浓度升高的空间范围 和饮用水，这将有助于改善受污染的 人口和风险。该项目将在以下方面做出新的贡献： 地球化学和健康的联系影响PFAS运输和流动性的地球化学因素， 与接触有关的人类健康风险。 !