Assessing the Contribution of Polyfluoroalkyl Precursors to Diverse PFAS Exposures near Contaminated Sites

项目摘要/摘要--项目1曝光 美国数百个地点受到多氟烷基物质(PFAS)的污染，这些物质已经被 与对免疫功能、新陈代谢和内分泌健康的有害影响有关。工程项目1 全氟辛烷磺酸的来源、运输、暴露和影响(陡峭)中心(P1-暴露)提供关键联系 通过聚焦全氟辛烷磺酸暴露在生物医学和工程项目之间 受污染的超级基金地点(空气、水和鱼)。P1--暴露直接涉及SRP的任务规定 “……开发检测危险物质并评估其对人类构成的风险的方法和资源 通过开发支持全氟辛烷磺酸暴露的新的机制和统计工具，实现“健康” 与P4-Detect合作进行评估和创新的环境测量使用一套 关闭PFAS大规模预算的分析技术。P1--接触研究对整体陡峭的 二、目标是“评估全氟辛烷磺酸的分布、转化和生物积累，并参与新的和 在多个站点上建立了利益相关者。大多数以前的工作都集中在有限的全氟辛烷磺酸分析物套件上， 通过水介质运输，并以饮用水为主要曝露媒介。然而，丰富的 已在环境样品中检测到降解为末端全氟辛烷基磺酸的多氟烷基前体， 大气沉降日益被认为是全氟辛烷磺酸的主要传输途径，并受到污染 海鲜是人类接触的另一个重要媒介。P1暴露的中心假说是 由于大量未被检测到的环境全氟辛烷磺酸暴露被大大低估 空气、水和生物群中存在的多氟烷基前体。目标1和目标2将调查全氟辛烷磺酸的倾向 利用在马萨诸塞州科德角的实地研究，在AFFF下游的水生食物网中生物积累的前体- 受污染的场地。从实地研究和合作中对全氟辛烷磺酸生物积累机制的新认识 与传统的SRP相比，使用P3-机制将在机械性食物网模型中形式化 关注的污染物(多氯联苯和甲基汞)，并用于了解时间趋势 在P2中对法罗群岛儿童暴露于海鲜中的关键影响。AIM 3将开发建模工具，用于 表征美国邻近地区全氟辛烷磺酸的大气源-受体关系 加强统计方法，以预测马萨诸塞州可能存在全氟辛烷磺酸污染的私人油井， 密歇根州和新泽西州P1--接触研究将与许多利益攸关方合作进行，包括 马萨诸塞州科德角的马什皮-万帕诺亚格部落与CEC和州项目经理以及 马萨诸塞州、密歇根州和新泽西州的科学家。针对新测量和模型的所有建模和数据管理实践 产出将得到Stop的DMAC的支持。P1--接触研究和与多个州接触将 通过RETCC提供充足的培训机会。 1

PROJECT SUMMARY/ABSTRACT – PROJECT 1 EXPOSURE Hundreds of U.S. sites are contaminated by poly- and perfluoroalkyl substances (PFAS), which have been associated with deleterious impacts on immune function, metabolism, and endocrine health. Project 1 of the Sources, Transport, Exposure, and Effects of PFAS (STEEP) Center (P1–Exposure) provides a critical link between the biomedical and engineering projects by focusing of PFAS exposure sources of concern near contaminated Superfund sites (air, water, and fish). P1–Exposure directly addresses the SRP mandate to “...develop methods and resources to detect hazardous substances and assess the risks they pose to human health” through the development of novel mechanistic and statistical tools to support PFAS exposure assessment and innovative environmental measurements in collaboration with P4–Detection using a suite of analytical techniques to close the PFAS mass budget. P1–Exposure research is essential to the overall STEEP II goals to “Assess the distribution, transformation and bioaccumulation of PFAS and “Engage new and established stakeholders across multiple sites.” Most prior work has focused on a limited suite of PFAS analytes, transport through aqueous media, and drinking water as the main vector of exposure. However, abundant polyfluoroalkyl precursors that degrade into terminal PFAS have been detected in environmental samples, atmospheric deposition is increasingly recognized as a major PFAS transport pathway, and contaminated seafood is another important vector for human exposure. The central hypothesis of P1–Exposure is that environmental PFAS exposures have been substantially underestimated due to large quantities of undetected polyfluoroalkyl precursors present in air, water, and biota. Aims 1 and 2 will investigate the propensity of PFAS precursors for bioaccumulation in aquatic food webs using field research in Cape Cod, MA, downstream of AFFF- contaminated sites. New knowledge of PFAS bioaccumulation mechanisms from field research and collaboration with P3–Mechanisms will be formalized in a mechanistic food web model, compared to traditional SRP contaminants of concern (polychlorinated biphenyls and methylmercury), and applied to understand time trends in seafood exposures for Faroese children in P2–Critical Effects. Aim 3 will develop modeling tools for characterizing atmospheric source-receptor relationships for PFAS across the contiguous U.S. Aim 4 will enhance a statistical approach for predicting private wells likely to have PFAS contamination in the states of MA, MI, and NJ. P1–Exposure research will be conducted in partnership with many stakeholders including the Mashpee-Wampanoag Tribe on Cape Cod, MA in partnership with CEC and state program managers and scientists in MA, MI, and NJ. All modeling and data management practices for new measurements and model output will be supported by STEEP’s DMAC. P1–Exposure research and engagement with multiple states will provide ample training opportunities through the RETCC. 1