Spatial patterns of metals and metal mixtures in drinking water
饮用水中金属和金属混合物的空间格局
基本信息
- 批准号:10559491
- 负责人:
- 金额:$ 16.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-02-21 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:5 year oldAddressAffectArchivesArsenicBiomedical ResearchBrainCadmiumChildChromiumCognitiveCognitive agingColoradoConsumptionCountryDataDatabasesDevelopmentDiagnosisEffectivenessElderlyElementsExposure toGeographic LocationsGeological SurveyGoalsGuidelinesHealthHeavy MetalsHybridsImmunosuppressionIn VitroIndividualInformation SystemsLeadLinkLocationMalignant NeoplasmsManganeseMapsMeasurementMetal exposureMetalsMethodsModelingMunicipalitiesNurses&apos Health StudyOrganoidsOxidation-ReductionPatternPersonsPoisonPopulationPrivatizationProcessPropertyProspective cohortPublic HealthRegulationResearchResearch PriorityRiskRisk AssessmentRoleSamplingSeleniumSiteSoilSourceSuperfundSurfaceSystemTechnologyTestingTimeToxicity TestsTrace metalTrainingTreatment EffectivenessUnited StatesWaterWater PollutantsWater SupplyWomanWorkcommunity engagementcontaminated drinking watercontaminated waterdisease registrydrinking waterearly life exposureeffectiveness evaluationexposed human populationgeochemistryground waterhigh riskimprovedinnovative technologiesinsightland usemachine learning algorithmneurodevelopmentnovelremediationrisk mitigationsuperfund sitetoolwater qualitywater samplingwater treatment
项目摘要
PROJECT SUMMARY/ABSTRACT
In 2016, approximately 15 million people lived within one mile of Superfund sites, including approximately 5% of
all children in the United States (US) under 5 years of age. Lead (Pb), arsenic (As), and cadmium (Cd) are
among the top ten contaminants on the Agency for Toxic Substances and Disease Registry’s 2017 Substances
Priorities List for Superfund sites. These and other metals/metalloids can contaminate surface waters and
groundwater systems, leading to elevated exposures through drinking water. Across the US, tens of millions of
individuals consume drinking water with concentrations of heavy metals in excess of regulatory guidelines.
Exposures to heavy metals have been associated with many negative impacts on public health, including impacts
on neurodevelopment and cognitive aging. However, the contribution of different Superfund sites to this
contamination problem remains poorly characterized on a national scale. This is important because regulations
for drinking water contaminants and risk mitigation actions are often undertaken at the federal level, but most
prior work has focused on site-specific studies. Proximity to Superfund sites may be associated with higher risk
of contamination by heavy metal mixtures in tap water. This relationship is likely more prominent in private wells
than in municipal drinking water supplies, where the finished water quality is influenced by water treatment
technologies. Across different geographic areas, there are considerable differences in municipal water treatment
technology and continuous development of innovative technologies, but little information is available on how this
affects spatial patterns of metal concentrations in tap water. In Aim 1, we will characterize the role of Superfund
sites across the country for heavy metals in private wells by developing novel hybrid mechanistic-empirical
models for heavy metals across the US using a large database of measurements in groundwater from the USGS,
locations of point sources such as Superfund sites, and hydrogeological features/predictors that affect the fate
and transport of trace metals. For Aim 2, we will use new measurements and models to identify the spatial co-
occurrence of different metal mixtures relevant to human exposures from drinking water. This analysis will be
used to identify the composition of metal mixtures for in vitro toxicity tests on brain organoids in Project 2. Aim 3
will leverage >28 million measurements of heavy metals from municipal water supplies to field-evaluate the role
of different treatment technologies. This will provide insights into the effectiveness of treatment technologies and
can help inform Project 4 as well as Superfund site managers responsible for remediation. This project provides
a link between biomedical research in the MEMCARE Center, human exposures, and potential benefits of
remediation technology being developed in Project 4.
项目总结/摘要
2016年,约有1500万人居住在超级基金场地一英里范围内,其中约5%的人居住在超级基金场地周围。
美国(US)5岁以下的所有儿童。铅(Pb)、砷(As)和镉(Cd)是
在有毒物质和疾病登记署2017年的十大污染物中,
超级基金站点的优先级列表。这些和其它金属/准金属可污染地表沃茨,
这可能会影响到地下水系统,导致通过饮用水的暴露增加。在整个美国,
个人饮用的饮用水中重金属浓度超过了规定的标准。
暴露于重金属会对公众健康产生许多负面影响,包括
关于神经发育和认知老化的研究然而,不同的超级基金网站对此的贡献
在全国范围内,污染问题的特点仍然很不明显。这很重要,因为法规
饮用水污染物和风险缓解行动往往在联邦一级进行,但大多数
先前的工作侧重于具体地点的研究。接近超级基金地点可能与更高的风险有关
自来水中的重金属混合物污染。这种关系在私人威尔斯井中可能更为突出
而在市政饮用水供应中,成品水质量受到水处理的影响
技术.在不同的地理区域,市政水处理有很大的差异
技术和创新技术的不断发展,但很少有信息说明这是如何实现的。
影响自来水中金属浓度的空间模式。在目标1中,我们将描述超级基金的作用
通过开发新的混合机械-经验方法,
利用美国地质勘探局地下水测量数据库,
点源的位置,如超级基金场地,以及影响结果的水文地质特征/预测因素
和微量金属的运输。对于目标2,我们将使用新的测量和模型来确定空间协同,
与人类从饮用水中接触有关的不同金属混合物的出现。该分析将
用于确定项目2中脑类器官体外毒性试验的金属混合物的组成。目标3
将利用城市供水中超过2800万个重金属测量值来实地评估其作用
不同的治疗技术。这将有助于深入了解治疗技术的有效性,
可以帮助通知项目4以及负责补救的超级基金现场经理。这个项目提供
MEMCARE中心的生物医学研究、人类暴露和
项目4正在开发的补救技术。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Elsie Mareca Sunderland其他文献
Elsie Mareca Sunderland的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Elsie Mareca Sunderland', 18)}}的其他基金
Spatial patterns of metals and metal mixtures in drinking water
饮用水中金属和金属混合物的空间格局
- 批准号:
10332731 - 财政年份:2020
- 资助金额:
$ 16.75万 - 项目类别:
Spatial patterns of metals and metal mixtures in drinking water
饮用水中金属和金属混合物的空间格局
- 批准号:
10112927 - 财政年份:2020
- 资助金额:
$ 16.75万 - 项目类别:
Assessing the Contribution of Polyfluoroalkyl Precursors to Diverse PFAS Exposures near Contaminated Sites
评估多氟烷基前体对污染场地附近各种 PFAS 暴露的影响
- 批准号:
10352510 - 财政年份:2017
- 资助金额:
$ 16.75万 - 项目类别:
Assessing the Contribution of Polyfluoroalkyl Precursors to Diverse PFAS Exposures near Contaminated Sites
评估多氟烷基前体对污染场地附近各种 PFAS 暴露的影响
- 批准号:
10704007 - 财政年份:2017
- 资助金额:
$ 16.75万 - 项目类别:
Sources, Transport, Exposure and Effects of PFASs (STEEP)
PFAS 的来源、传输、暴露和影响 (STEEP)
- 批准号:
9904670 - 财政年份:
- 资助金额:
$ 16.75万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 16.75万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 16.75万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 16.75万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 16.75万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 16.75万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 16.75万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 16.75万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 16.75万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 16.75万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 16.75万 - 项目类别:
Research Grant