Phenotyping and Environmental Modifier Facility Core

表型分析和环境修饰设施核心

• 批准号: 9904640
• 负责人: Rosalind J Wright
• 金额: $ 23.53万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9904640
• 关键词: Address; Adolescence; Adult; Age; Archives; Area; Asthma; Behavior; Bioinformatics; Biological; Biological Markers; Biometry; Cardiovascular system; Chemical Modifier; Chemicals; Child; Childhood; Clinical; Clinical Research; Clinical and Translational Science Awards; Collaborations; Communities; Consultations; Core Facility; Data; Data Analyses; Data Collection; Development; Disease; Educational workshop; Electronic Health Record; Endocrine; Ensure; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Risk Factor; Equilibrium; Equipment; Exposure to; Faculty; Funding; Growth; Health; Health Sciences; Health Status; Health system; Hydrocortisone; Hypersensitivity; Immunophenotyping; Integration Host Factors; Intervention; Kidney; Laboratories; Libraries; Life Cycle Stages; Link; Longevity; Measurement; Measures; Mediating; Mediation; Methodology; Methods; Mission; Modeling; Multivariate Analysis; National Institute of Environmental Health Sciences; Nutrition Assessment; Nutritional; Nutritional status; Obesity; Online Systems; Outcome; Oxidative Stress; Pathway interactions; Patient Self-Report; Phenotype; Physiological; Plasma; Population; Precision Medicine Initiative; Pregnancy; Procedures; Protocols documentation; Psychological Stress; Psychometrics; Psychosocial Stress; Research; Research Support; Resources; Risk; Salivary; Science; Services; Site; Societies; Standardization; Stress; Surveys; Technical Expertise; Time; Toxic Environmental Substances; Toxicant exposure; Training; Translational Research; Work; adipokines; base; built environment; cardiometabolism; clinical phenotype; contextual factors; critical period; data sharing; early childhood; health assessment; health data; health disparity; hypothalamic-pituitary-adrenal axis; immunoregulation; infancy; instrument; interoperability; meetings; member; neurodevelopment; nutrition; performance based measurement; phenomics; phenotypic data; pre-clinical; ranpirnase; research study; respiratory; response; sample collection; social determinants; social health determinants; socioeconomics; tool; toxicant; web portal

Project Summary Our Phenotyping and Environmental Modifier Facility Core (PEMFC) organizes Mount Sinai's extensive existing environmental epidemiology, clinical, psychometric, analytic and technical expertise as a key Center resource. The PEMFC helped catalyze the remarkable growth in environmental health research over the first 3 years of our Center linking environmental exposure and their modifiers to measures of health and development. The PEMFC provides Center Members access to expertise and state-of-the-art equipment necessary for clinical phenotyping and quantification of health and developmental outcomes across the lifespan as well as the measurement of modifiers of chemical environmental toxins. The PEMFC provides clinical, technical and scientific input to enhance the selection of age-appropriate valid, reliable and time effective low burden instruments to measure health and disease across the lifespan with particular focus on critical periods (pregnancy, infancy, early childhood, adolescence) . This includes Center supported space and phenotyping equipment covering target priority areas identified to date (neurodevelopment/behavior, obesity, asthma, allergy, endocrine, renal and cardiovascular phenotypes). The Core also facilitates translational research aimed toward more fully elucidating the impacts of key interactions between chemical toxicants and environmental modifiers across development, specifically psychological stress and other social determinants as well as nutrition. Given that exposure to chemical and non-chemical toxicants as well as nutritional status often track together along socioeconomic gradients, a related focus will be the multi-faceted elucidation of mechanisms underlying the health disparities observed in our local communities and more globally. The scope of responsibility for the PEMFC includes: 1) maintaining and providing access to adult and pediatric health assessments that include self-reports, observational data, and performance based measures; 2) assisting Center Members with rigorous and appropriate protocols to use when applying such measures in research studies; 3) advising on data analysis that includes psychometric analyses including the use of multiple phenotypes in a phenomic or true multivariate analysis; and 5) integrating environmental health with precision medicine initiatives at Mount Sinai. The PEMFC curates measures identified by our expert faculty together with the information needed to implement the measures including a summary of the psychometrics and detailed protocol(s) for data collection, scoring procedures, and incorporation into analyses. PEMFC faculty have particular expertise to guide selection of measures that can be characterized through a common standardized metric in order to facilitate data sharing, interoperability and harmonization to catalyze opportunities for Center Members to participate in collaborative multi-site studies. PEMFC faculty will also work with our clinical colleagues to integrate environmental health data with electronic health record data to catalyze environmental health translational research across the Mount Sinai Health System.

项目摘要 我们的表型和环境修饰剂设施核心（PEMFC）组织西奈山的广泛的 现有的环境流行病学，临床，心理测量，分析和技术专业知识作为一个关键中心 resource. PEMFC帮助催化了环境健康研究在前3年的显着增长 多年来，我们的中心将环境暴露及其修饰剂与健康措施联系起来， 发展PEMFC为中心成员提供专业知识和先进设备 临床表型分析和健康和发育结果的量化所必需的 寿命以及化学环境毒素改性剂的测量。 PEMFC提供 临床、技术和科学投入，以加强选择与年龄相适应的有效、可靠和及时的 有效的低负担工具来衡量 健康和疾病，特别关注 关键时期（怀孕、婴儿期、幼儿期、青春期） .这包括中心支持的空间， 表型分析设备，涵盖迄今为止确定的目标优先领域（神经发育/行为，肥胖， 哮喘、变态反应、内分泌、肾和心血管表型）。 核心还促进了翻译 研究旨在更充分地阐明化学毒物之间的关键相互作用的影响， 发展过程中的环境因素，特别是心理压力和其他社会决定因素 以及营养。鉴于接触化学和非化学毒物以及营养状况 经常沿着沿着社会经济梯度一起跟踪，相关的焦点将是多方面的说明， 在我们的地方社区和全球范围内观察到的健康差距的根本机制。的 质子交换膜燃料电池的职责范围包括：1）维护和提供成人和儿童的通道 健康评估，包括自我报告、观察数据和基于性能的测量; 2） 协助中心成员在实施此类措施时使用严格和适当的协议， 研究; 3）提供数据分析方面的建议，包括心理测量分析，包括使用 在表型或真正的多变量分析中的多个表型;以及5）将环境健康与 西奈山的精准医疗计划 PEMFC策划由我们的专家教师确定的措施 以及实施措施所需的信息，包括心理测量学摘要 以及数据收集、评分程序和纳入分析的详细方案。PEMFC 教师有特殊的专业知识，以指导选择的措施， 可以通过一个共同的 标准化度量 为了方便 数据共享、互操作性和协调， 中心成员有机会参与多中心协作研究。PEMFC教师也将工作 与我们的临床同事一起，将环境健康数据与电子健康记录数据相结合， 西奈山卫生系统的环境健康转化研究。